A5074102747- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Fungal Infections and Studies
- Head and Neck Cancer Studies
- Plant Pathogens and Fungal Diseases
- Acne and Rosacea Treatments and Effects
- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- Prostate Cancer Diagnosis and Treatment
- Neurological Complications and Syndromes
- Cancer Research and Treatments
- Antifungal resistance and susceptibility
- Moyamoya disease diagnosis and treatment
- Gut microbiota and health
- Intracranial Aneurysms: Treatment and Complications
- Oral Health Pathology and Treatment
- Fungal Biology and Applications
- Nonmelanoma Skin Cancer Studies
- Infectious Diseases and Mycology
- Advanced Radiotherapy Techniques
- Cutaneous lymphoproliferative disorders research
- Pharmacological Effects of Natural Compounds
- Molecular Biology Techniques and Applications
- Allergic Rhinitis and Sensitization
- Cerebrovascular and Carotid Artery Diseases
National Clinical Research Center for Digestive Diseases
2020-2025
Peking University First Hospital
2014-2025
Peking University
2014-2025
National Clinical Research
2024-2025
Nanjing Medical University
2020-2025
Beijing University of Chemical Technology
2024
Robert Bosch (Germany)
2024
Xuzhou Medical College
2024
Taishan University
2024
Harbin Institute of Technology
2024
<h3>Objective</h3> To investigate the long term outcomes after conservative and surgical treatment for haemorrhagic moyamoya disease. <h3>Methods</h3> 97 consecutive patients with disease from 1997 to 2009 were enrolled in this study (mean age 31±10 years; range 5–56 years). We reviewed clinical charts radiographs of at first bleeding episode. Follow-up was obtained prospectively by questionnaires radiographic examinations. Outcomes compared based on initial (conservative vs surgical)....
Generalized pustular psoriasis (GPP) in pregnancy can lead to severe complications for both mother and fetus. The treatment of this disease is challenging, especially recalcitrant cases. Until present, there are no evidence-based guidelines the GPP pregnancy. Spesolimab, a human monoclonal antibody against IL-36 receptor, has recently attracted attention as new therapy flare. This biologic provides rapid sustained control symptoms flare, although its use pregnant women not been reported...
Mesenchymal stem cells (MSCs) were adenovirally engineered to secrete interleukin-12 (AdIL-12-MSCs) and evaluated for their anticarcinogenesis efficacy against three kinds of unestablished tumor models including B16 melanoma, LLC Lewis lung cancer HCC hepatoma. Injection AdIL-12-MSCs into protected mice before inoculation prevented all 12 in preventive groups, 10 out model 11 hepatoma from developing tumors, whereas the control groups pre-receiving PBS validated 100% carcinogenesis;...
Journal Article Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus their correlations with symptoms prognosis Get access R. Wang, Wang Department Dermatology Peking University First Hospital 8 Xishiku Street Xicheng District Beijing 100034 ChinaBeijing Key Laboratory Molecular Diagnosis Dermatoses China Correspondence Mingyue Wang. E‐mail: wangmy@pku.edu.cn Search for other works by this author on: Oxford Academic Google Scholar J. Li, Li Jishuitan M....
We assessed the effects of protein kinase C ɛ (PKCɛ) for improving stem cell therapy acute myocardial infarction (AMI). Primary mesenchymal cells (MSCs) were harvested from rat bone marrow. PKCɛ-overexpressed MSCs and control transplanted into infarct border zones in a AMI model. PKCɛ distribution expression principal proteins involved signaling through stromal cell-derived factor 1 (SDF-1)/CXC chemokine receptor type 4 (CXCR4) axis phosphatidylinositol 3 (PI3K)/protein B (AKT) pathway...
Seborrhoeic dermatitis (SD) is a common chronic inflammatory dermatosis. Current theories on the pathogenesis of SD highlight role microbes skin surface. Ketoconazole commonly used for treatment SD; however, there are limited data focusing effects ketoconazole in shaping microbiome patients with SD.In this prospective cohort study, we high-throughput DNA sequencing method to characterize cutaneous microbial communities before and after topical treatment.In total, 30 facial 15 age-...
ABSTRACTGenomes of strains the zoophilic dermatophyte Microsporum canis from invasive (disseminated and subcutaneous) noninvasive (tinea capitis) infections were compared. Especially disseminated strain showed significant syntenic rearrangements, including multiple translocations inversions, numerous SNPs Indels in comparison to strain. In transcriptome analysis, both enriched for GO pathways related components membrane, iron binding heme binding, which possibly enables them invade deeper...
Objective This study aims to analyze the different therapeutic responses between topical antimicrobial–corticosteroid combination and corticosteroids alone on improving skin microbiome barrier of patients with atopic dermatitis (AD).
Our study is the first to compare fungal microbiome changes in atopic dermatitis (AD) patients before and after treatment with upadacitinib dupilumab. We found that more effectively restores levels observed healthy individuals, which may contribute its superior efficacy head neck (a subtype of AD). The results enhance understanding how JAK inhibitors influence skin AD.
Vulvovaginal candidiasis (VVC) is an inflammation caused by Candida albicans with a higher recurrence rate in individuals deficient Card9. This study aimed to elucidate the mechanisms underlying this increased susceptibility. Estrogen-treated Card9-/- mice infected C. were used model Card9 deficiency-related VVC. Our findings indicate that deficiency leads reduction Th17 cells, interleukin (IL)-17-producing γδ T and IL-17A secretion, weakens epithelial tight junctions, reduces antimicrobial...
Objective: To evaluate the clinical efficacy of left ventricular assist device(LVAD) in treatment end-stage heart failure. Methods: This is a multicenter retrospective case series study. Data were retrospectively analyzed from 48 patients treated at eight domestic cardiac surgery centers China between March 2022 and September 2024, who underwent LVAD implantation due to All surgeries led by cardiovascular team Nanjing First Hospital. The study included 42 male 6 female patients, aged...
Objective: To observe the clinical efficacy of spinal cord stimulation (SCS) in treating lower extremity peripheral arterial disease (PAD). Methods: A retrospective analysis was conducted on data patients diagnosed with PAD at Nanjing Hospital Medical University from October 2021 to August 2024. Patients were divided into SCS group and control based whether they underwent implantation surgery. Propensity score matching (PSM) applied match two groups. The numeric rating scale (NRS) score,...
Abstract With the increasingly prominent issues of environmental pollution and resource depletion, vigorously developing renewable energy has become an important consensus among countries. Addressing inherent intermittency sources, storage a top priority. The AA - CAES system coupled with photothermal can expand application scenarios power plants improve cycle efficiency. This article conducts research on technology high-temperature thermal (CAES HTPT) for large-scale above 100 MW. A...
The value of anti-angiogenesis antibody therapy in recurrent or metastatic nasopharyngeal carcinoma (R/M NPC) remains unknown. We carried out a phase II study to evaluate the addition bevacizumab paclitaxel plus carboplatin R/M NPC.A total 80 patients with previously untreated NPC were randomly assigned (1 : 1) CPB CP groups receive (area under curve 6) and (175 mg/m2) intravenously every 3 weeks for maximum six cycles combination without (7.5 mg/kg), respectively. primary endpoint was...
The aim was to describe the profiles of hemorrhagic patterns moyamoya disease (MMD) and analyze risk factors in a large population.A total 335 conservatively managed MMD patients with hemorrhage our hospital were included this cross-sectional study. correlation between clinical angiographic characteristics (anterior or posterior hemorrhage) assessed hemisphere by univariate multivariate logistic regression models. In addition, stratified analysis performed.The hemispheres (patients)...