Purpose Iron deficiency is prevalent in distance runners and may impair endurance performance. The current practice of oral supplementation slow often not well tolerated. aim this study was to assess the efficacy intravenous (IV) iron (ferric carboxymaltose) compared with (ferrous sulfate) on status, hemoglobin mass (Hbmass), physiological indices running performance runners. Methods Twenty-seven highly trained low (LOW) (ferritin <35 μg·L−1 transferrin saturation <20%, or ferritin <15...

Haemoglobin mass in a female endurance athlete was measured via carbon monoxide rebreathing upon diagnosis of iron-deficiency anemia (haemoglobin concentration = 8.8 g/dL, ferritin 9.9 ng/mL) and regularly during treatment thereafter. increased by 49% the 2 wk following an intramuscular iron injection continued to increase with oral supplementation for 15 wk. The presented case illustrates that haemoglobin is readily responsive severely iron-deficient anemic changes can be tracked...

Plasma volume and red cell mass are key health markers used to monitor numerous disease states, such as heart failure, kidney disease, or sepsis. Nevertheless, there is currently no practically applicable method easily measure absolute plasma volumes in a clinical setting. Here, novel marker for was developed through analysis of the observed variability caused by shifts common biochemical measures, selected based on their propensity present with low variations over time. Once month 6 months,...

ABSTRACT In collaboration with various Anti‐Doping Organisations and the Paris WADA‐accredited laboratory, International Testing Agency spearheaded implementation of Endocrine Module ahead Olympic Games 2024. This article presents a data‐driven evaluation its early integration within Athlete Biological Passport (ABP) programmes. The assessment endocrine profile testing follows complete ABP sample lifecycle, from collection to submission reports by Management Unit. identifies both challenges...

The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted prevalence blood manipulations in elite sports. However, ABP relies on a number concentration‐based markers erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts plasma volume (PV). Fluctuations PV contribute to majority biological variance associated with volumetric markers. Our laboratory recently identified panel common chemistry (from simple test) capable...

The Athlete Biological Passport (ABP) detects blood doping in athletes through longitudinal monitoring of erythropoietic markers. Mathematical algorithms are used to define individual reference ranges for these markers each athlete. It is unclear if altitude and exercise can affect the variables included calculations a way that changes might be mistaken manipulation. aim this study was investigate influence simultaneous strenuous low high exposure on calculation ABP. 14 sea level (SL) 11...

Health-professional regulation plays a central role in patient safety by responding to concerns about the conduct of health practitioners that may breach professional standards. This study aims understand experience both complainants and registered during management notification (complaint or concern) with health-practitioner board Australia. Experience-survey responses from (n=1,217) (n=1,604) recently closed were analyzed using descriptive thematic analysis. Respondents groups felt process...

Abstract Altitude is a confounding factor within the Athlete Biological Passport (ABP) due, in part, to plasma volume (PV) response hypoxia. Here, newly developed PV blood test applied assess possible efficacy of reducing influence on volumetric ABP markers; haemoglobin concentration ([Hb]) and OFF‐score. Endurance athletes (n=34) completed 21‐night simulated live‐high train‐low (LHTL) protocol (14 h.d ‐1 at 3000 m). Bloods were collected twice pre‐altitude; days 3, 8, 15 altitude; 1, 7, 21,...

Summary Introduction Fluctuations in ambient temperature and pressure, as well physical jostling, may affect the stability of whole blood samples transported by air freight. The aim this study was to characterize key variables during freight investigate whether vibration or reduced pressure alone affected results. Methods Over a 72‐h interval, we evaluated full count indices (plus reticulocytes) tubes that were air‐freighted total 2, 10 28 h. We also examined impact 24 h atmospheric (750 hpa...

The Athlete Biological Passport (ABP) estimates individualized reference ranges for key blood markers, such as haemoglobin concentration ([Hb]), using predetermined population mean, between- and within-subject variances. Here, we aim to reassess previously published [Hb] variance determine whether sex-, analyzer-, sport-, or season-specific values are required. Our contains 7723 male (mean ± SD, 22.3 4.6 years of age) 6164 female (21.6 4.3) athlete observations from 49 sports. was calculated...

Abstract Fluctuations in plasma volume (PV) present potential confounders within the concentration‐based markers of haematological athlete biological passport (ABP). Here, a multi‐parametric approach involving simple blood test is applied to current ABP adaptive model an attempt remove influence PV expansion, induced by cycling stage race. Blood samples were obtained from 29 professional cyclists (14 male, 15 female) before, during and after 4–5 consecutive days racing. Whole was analysed...

Background and Objectives: The development of athlete-specific hematological reference ranges are essential for sports physicians in the diagnosis pathologies. Due to unique genetics training modalities, athletes known have atypical hematologic profiles comparison general population between ethnic groups. aims this study were 1) develop 2) demonstrate effect ethnicity on key variables, order improve athlete care. Methods: From a 2082 healthy male (M) (23.28 ± 4.89 years age) 140 female (F)...

Plasma volume (PV) is a valuable measure in exercise physiology since it key factor heat acclimatization and the adaptation to exercise. Volume also has potential uses other areas such as medicine for management critical care patients anti-doping. For test-retest quality assurance purposes, reliability accuracy of PV measures essential all these disciplines. PURPOSE: To compare related determined using two different analysers. METHODS: 36 healthy, endurance trained males (36.7±7.6 y,...

The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted prevalence blood manipulations in elite sports. However, ABP relies on a number concentration-based markers erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts plasma volume (PV). Fluctuations PV contribute to majority biological variance associated with volumetric markers. Our laboratory recently identified panel common chemistry (from simple test) capable...

More than 30 years ago people have learned that exercise promotes oxidative damage in human tissues. Since then, our knowledge on exercise-induced free radical production and their effect has advanced markedly. In the beginning research mainly focused detrimental effects of (e.g. oxidation macromolecules); however today a new era redox biology exist centers cell-signaling radicals, such as reactive oxygen species (ROS) were shown to play crucial role muscle adaptation exercise. Erythrocytes...