A5103234897- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Receptor Mechanisms and Signaling
- High Altitude and Hypoxia
- Esophageal and GI Pathology
- Neuroscience and Neuropharmacology Research
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Screening and Detection
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuropeptides and Animal Physiology
- Inflammatory Biomarkers in Disease Prognosis
- Winter Sports Injuries and Performance
- Neurological Disorders and Treatments
- COVID-19 and healthcare impacts
- Cancer-related molecular mechanisms research
- Gastroesophageal reflux and treatments
- Cholinesterase and Neurodegenerative Diseases
- Colorectal Cancer Surgical Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Beijing Hospital
2024
Shanghai Research Institute of Sports Science
2014-2024
Qinghai Normal University
2022-2023
Beijing Normal University
2023
Huazhong Agricultural University
2023
Beijing Hospital of Traditional Chinese Medicine
2023
Capital Medical University
2023
State Forestry and Grassland Administration
2023
Peking Union Medical College Hospital
2018-2020
Abstract The tumor microenvironment (TME) in gastric cancer (GC) has been shown to be important for control but the specific characteristics GC are not fully appreciated. We generated an atlas of 166,533 cells from 10 patients with matched paratumor tissues and blood. Our results show tumor-associated stromal (TASCs) have upregulated activity Wnt signaling angiogenesis, negatively correlated survival. Tumor-associated macrophages LAMP3 + DCs involved mediating T cell form intercellular...
Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide, underscoring an urgent need for the development early detection strategies and precise postoperative interventions. However, identification non-invasive biomarkers diagnosis patient risk stratification remains underexplored. Here, we conduct targeted metabolomics analysis 702 plasma samples from multi-center participants to elucidate GC metabolic reprogramming. Our machine learning reveals...
AIMTo examine the impact of aging on short-term outcomes following pancreatic resection (PR) in elderly patients. METHODSA retrospective cohort study using prospectively collected data was conducted at China National Cancer Center.Consecutive patients who underwent PR from January
The benefit of neoadjuvant chemotherapy for patients with signet-ring cell carcinoma the stomach is controversial.To evaluate perioperative and long-term outcomes locally advanced gastric carcinoma.This retrospective study identified carcinomas (cT3/4 cN any) diagnosed from January 2012 to December 2017 by using clinical Tumor-Node-Metastasis (cTNM) staging system. We performed 1:1 propensity score matching (PSM) reduce bias in patient selection. histologic prognostic effects were assessed....
To assess the ability of clinical inflammatory models to predict tumor regression grade (TRG) in response neoadjuvant chemoradiotherapy (NCRT) and survival patients with locally advanced rectal cancer (LARC). We retrospectively analyzed 161 LARC who underwent NCRT followed by total mesorectal excision at Beijing Hospital between May 2007 March 2022. By using logistic Cox analyses, we developed prediction for TRG overall (OS), respectively. Multivariable analysis indicated that variations...
Background . The prognostic relevance of gastric tumor location has been reported and debated. Our study was conducted to examine the differences in clinicopathological features, factors, overall survival (OS) between patients with proximal cancer (PGC) distal (DGC). Patients Methods PGC or DGC were identified from China National Cancer Center Gastric Database (NCCGCDB) during 1997–2017. Survival analysis performed via Kaplan-Meier estimates Cox proportional hazards models. Results We...
Background: The Naples prognostic score (NPS) is established according to nutritional or inflammatory state, which has been identified as a new for various malignant tumors. However, its prognosis prediction effect on gastric cancer (GC) patients still unknown so far. present work aimed examine the NPS function in of GC prognosis. Methods: In this study, undergoing surgery with no preoperative therapy were retrospectively examined from June 2011 August 2019. Typically, total cholesterol...
Plasma volume (PV) can be modulated by altitude exposure (decrease) and periods of intense exercise (increase). Cycle racing at combines both stimuli, although presently no data exist to document which is dominant. Hemoglobin mass (Hbmass), hemoglobin concentration ([Hb]), percent reticulocytes (%Retics) (ALT; n = 9) sea-level (SL; residents were measured during a 14-day cycling race, held 1,146-4120 m, as well simulated tour near sea level (SIM; 12). Hbmass was assessed before on days 9 14...
There is no consensus regarding whether metastasectomy in gastric cancer patients with Krukenberg tumors (KTs) associated survival benefits. The aim of this study was to evaluate the treatment KTs origin a large series and identify prognostic factors affecting survival.All who were diagnosed ovarian metastases single medical center between January 2006 December 2016 identified included. divided into two groups according modality: group nonmetastasectomy group. Clinicopathological features...
Purpose The purpose of this study was to quantify the effects moderate-high altitude on power output, cadence, speed and heart rate during a multi-day cycling tour. Methods Power rate, cadence were collected from elite male road cyclists maximal efforts 5, 15, 30, 60, 240 600 s. completed in laboratory power-profile assessment, spontaneously race simulation near sea-level an international at altitude. Matched data highest mean output (MMP) corresponding recorded compared using paired...
Lifestyle factors and long-term survival of gastric cancer patients: A large bidirectional cohort study from China
The Athlete Biological Passport (ABP) detects blood doping in athletes through longitudinal monitoring of erythropoietic markers. Mathematical algorithms are used to define individual reference ranges for these markers each athlete. It is unclear if altitude and exercise can affect the variables included calculations a way that changes might be mistaken manipulation. aim this study was investigate influence simultaneous strenuous low high exposure on calculation ABP. 14 sea level (SL) 11...
This study aims to evaluate the safety and efficacy of lobaplatin in prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced gastric cancer.Advanced cancer patients who underwent radical resection and/or HIPEC were systematically reviewed our department from January 2016 June 2017. All enrolled grouped either or non-HIPEC groups. Clinical data collected analyzed.A total 129 with 61 cases group 68 group. The two groups well balanced terms clinical characteristics. In...
The necessity of additional gastrectomy for early gastric cancer (EGC) patients who do not meet curative criteria after endoscopic submucosal dissection (ESD) is controversial.To examine the clinicopathologic characteristics underwent laparoscopic ESD and to determine appropriate strategy treating those noncurative ESD.We retrospectively studied 45 with EGC from January 2013 2019 at Cancer Hospital Chinese Academy Medical Sciences. We analyzed patients' clinicopathological data identified...
The naples prognostic score (NPS) is established according to nutritional or inflammatory state, and it identified as the new for a variety of malignant tumors. However, its significance in cases suffering from adenocarcinoma esophagogastric junction (AEJ) who receive surgery remains unclear so far. In this study, patients receiving without preoperative therapy were examined between June 2007 August 2017 retrospective way. Typically, serum albumin level, total cholesterol...
Low body mass index is an independent predictor of poor long-term prognosis among patients with resectable gastric cancer