A5103284558- Pancreatic and Hepatic Oncology Research
- Bacterial Infections and Vaccines
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Neuroblastoma Research and Treatments
- Escherichia coli research studies
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Renal and related cancers
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Esophageal and GI Pathology
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Hangzhou First People's Hospital
2024
Zhejiang Chinese Medical University
2024
Westlake University
2024
Ministry of Education of the People's Republic of China
2024
Nankai University
2024
China Agricultural University
2023
Abstract Ubiquitination is an important modification process in eukaryotic organisms, and ubiquitin ligase (E3) the most diversified component of this system. APIP6 (AvrPiz-t interacting protein 6) one E3s rice, involved recognition AvrPiz-t, effector from pathogen Magnaporthe oryzae , for initiation host defense against M. . However, structural detail how performs its function remains elusive. Here, we present crystal structure RING domain (i.e., E2-interaction domain) (APIP6-RING)....
Escherichia coli K1 is the leading cause of neonatal gram-negative bacterial meningitis, but pathogenesis E meningitis remains unclear. Blood-brain barrier (BBB) penetration a crucial step in development. Here, we uncovered role CsiR, GntR family regulator, virulence. During infection, csiR expression was induced due to derepression by Fur blood and human brain microvascular endothelial cells (HBMECs). CsiR positively regulated ilvB expression, which associated with branched chain amino acid...