A5044050308- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Machine Learning in Materials Science
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Cardiac Arrest and Resuscitation
- Delphi Technique in Research
- Inhalation and Respiratory Drug Delivery
- S100 Proteins and Annexins
- Infection Control and Ventilation
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Hemodynamic Monitoring and Therapy
- Vitamin D Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Noise Effects and Management
- Vascular Procedures and Complications
- Advanced Proteomics Techniques and Applications
- Protease and Inhibitor Mechanisms
- Venous Thromboembolism Diagnosis and Management
Massachusetts General Hospital
2022-2025
Harvard University
2022-2025
Foundation for the National Institutes of Health
2024
National Institutes of Health
2023
Dartmouth College
2020-2022
Objectives This study aimed to assess the enduring impact of cross-clamp duration on postoperative sleep disturbance and functional outcomes (up 180 days) in cardiac surgery patients. Design is a secondary analysis data from randomized, double-blind trial comparing dexmedetomidine placebo for delirium prevention (Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep). Setting Data patients recruited at tertiary medical center Boston, Massachusetts, between March 2017...
Introduction: Postoperative delirium is common and associated with poor postoperative outcomes. However, the predictive power of intraoperative electroencephalogram (EEG) features for has not yet been well studied. Methods: Intraoperative EEG data from 261 patients who underwent major cardiac surgery were analyzed. Cases identified using Confusion Assessment Method. Predictive analytics outcome performed (1) only clinical data, (2) (3) a combined list important first two stages. Results:...
Delirium presents a significant healthcare burden. It complicates post-operative care in up to 50% of cardiac surgical patients with worse outcomes, longer hospital stays and higher cost care. Moreover, the nature delirium following surgery cardiopulmonary bypass (CPB) remains unclear, underlying pathobiology is poorly understood, status quo diagnostic methods are subjective, biomarkers currently lacking.To identify for insights into possible neuronal pathomechanisms.Comparative proteomic...
Wiredu, Kwame MD, PhD; McKay, Tina B. Qu, Jason MD; Akeju, Oluwaseun MD,MMSc Author Information
Background Survey research, indispensable for assessing subjective outcomes in anesthesiology, can nonetheless be challenging to undertake and interpret. Objective To present a user-friendly guide the appraisal of survey-derived evidence, apply it published survey research anesthesia literature. Methods Synthesizing expert guidance regarding methodology reporting, we discuss five essential criteria (with subcomponents) evaluating research: (1) relevance outcome objective, (2) trustworthiness...
Abstract Phosphorylation signaling is an essential post-translational regulatory mechanism that governs almost all eukaryotic biological processes and controlled by interplay between protein kinases phosphatases. Knowledge of direct substrates provides evidence mechanisms relate activity to function. Linking their can be achieved inhibiting or reducing kinase quantitative comparisons phosphoproteomes in the presence absence activity. Unfortunately, most human lack chemical inhibitors with...
Accurate quantification of proteomics data is essential for revealing and understanding biological signaling processes. We have recently developed a chemical proteomic strategy termed phosphatase inhibitor beads mass spectrometry (PIB-MS) to investigate endogenous phosphoprotein (PPP) dephosphorylation signaling. Here, we compare the robustness reproducibility status quo methods optimal performance ease implementation. then apply PIB-MS an array breast cancer cell lines determine differences...
Abstract Background Neurologic and neurobehavioural complications are common after cardiac surgery with cardiopulmonary bypass (CPB). Exposure to the artificial surface, conversion laminar flow hypothermia likely contribute systemic inflammation observed CPB. To ensure adequate oxygenation, CPB patient is often exposed supraphysiologic levels of oxygen. Relative normoxia, perioperative hyperoxia during has not been shown impact neurocognition in long-term. Whether this holds true for...
Abstract Purpose Delirium presents a significant healthcare burden. It complicates post-operative care in up to 50% of cardiac surgical patients with worse hospital outcomes, longer stays and higher overall cost care. Moreover, the nature delirium following surgery cardiopulmonary bypass (CPB) remains unclear, underlying pathobiology is poorly understood, status quo diagnostic methods are subjective, biomarkers currently lacking. Objective To identify for insights into possible neuronal...
Abstract Introduction: The upper extremity is a frequent site of injury. Upper limb arterial thromboembolism, rare complication such injuries, may be missed if typical signs, as pain, pulselessness, and sensory loss, cannot ascertained or are overlooked by physicians, especially in the case polytrauma comatose patients. Case presentation: In this report, we present left brachial artery thromboembolism patient for which embolectomy was performed. Before surgery, diagnosis established with...
Despite growing scientific knowledge and research, it is still unknown if office flexible laryngoscopy (FL) aerosol generating thereby potentially increases the risk of SARS-CoV-2 transmission. The limited literature that exists conflicting, precluding formal conclusions.To determine whether FL generating.This prospective cohort study included 134 patients seen in otolaryngology clinic at a single tertiary care academic institution between February May 2021. Two optical particle sizer...