A5091472298- Connective tissue disorders research
- Cardiac Valve Diseases and Treatments
- Melanoma and MAPK Pathways
- Cardiac Fibrosis and Remodeling
- Computational Drug Discovery Methods
- Dermatological and Skeletal Disorders
- Wound Healing and Treatments
- Cardiac Structural Anomalies and Repair
- Dupuytren's Contracture and Treatments
- Neurosurgical Procedures and Complications
- Viral Infectious Diseases and Gene Expression in Insects
- Skin Diseases and Diabetes
- Wnt/β-catenin signaling in development and cancer
- Head and Neck Surgical Oncology
- Skin and Cellular Biology Research
- FOXO transcription factor regulation
Medical University of South Carolina
2022-2025
Clemson University
2021
Intercellular interactions among cardiac cell populations are essential for morphogenesis, yet the molecular mechanisms orchestrating these events remain incompletely understood. Dachsous1 (Dchs1), an atypical cadherin linked to mitral valve prolapse, is a core planar polarity protein whose function in developing heart has not been fully elucidated. To address this, we generated Dchs1-HA knock-in mouse model define its spatial, temporal, and cellular expression patterns. Using...
<title>Abstract</title> Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks known genetic etiology. To identify contributions to hEDS, whole exome sequencing was performed on families and cohort of sporadic hEDS patients. A missense variant in <italic>Kallikrein-15</italic> (KLK15 p. Gly226Asp<italic>)</italic>,<italic> </italic>segregated with disease two burden analyses 197 patients revealed enrichment variants within the...
Trametinib is a MEK1 (mitogen-activated extracellular signal-related kinase 1) inhibitor used in the treatment of BRAF (rapid accelerated fibrosarcoma B-type)–mutated metastatic melanoma. Roughly 11% patients develop cardiomyopathy following long-term trametinib exposure. Although described clinically, molecular landscape cardiotoxicity has not been characterized. The aim this study was to test hypothesis that promotes widespread transcriptomic and cellular changes consistent with oxidative...
Cancer is the second most common cause of death in United States, accounting for 602,350 deaths 2020. Cancer-related rates have declined by 27% over past two decades, partially due to identification novel anti-cancer drugs. Despite improvements cancer treatment, newly approved oncology drugs are associated with increased toxicity risk. These toxicities may be mitigated pharmacokinetic optimization and reductions off-target interactions. As such, there a need early-stage implementation (PK)...
Skin burn wounds can be very serious injuries with high-risk healing processes and leaving life-long effects, regardless of the mechanism injury.Traditional methods treatment such as skin grafts early excision are unable completely regenerate skin.Therefore, new avenues being explored; one most promising potential treatments is use stem cells to enhance repair.Although multiple have been evaluated, more research necessary determine which method successful for widespread clinical...
Objective: We recently demonstrated regionalized myocardial fibrosis in patients undergoing surgical repair for Mitral Valve Prolapse. The location of suggests a mechanically driven process wherein mechanical stress alters the phenotype ventricular fibroblasts to promote an increase tissue stiffness, eventually causing establishment fibrotic scar. sought better understand how stiffness affected cellular programs. Methods: cultured primary human cardiac derived from same patient on stiff (TC...
Introduction: Regionalized myocardial fibrosis exists in the inferobasal myocardium of patients undergoing surgical repair for Mitral Valve Prolapse, and supports a process which cells within mechanically stressed regions alter their phenotype order to increase tissue stiffness, eventually causing establishment fibrotic scar. How behave different fibromechanical environments is not currently well understood. Hypothesis: Integrating RNA Seq ATAC datasets will identify mechanosensitive...