<i >Background</i>. The purpose of the present study is to determine association between neutrophil/lymphocyte ratio and both subclinical inflammation amyloidosis in familial Mediterranean fever. >Methods</i>. Ninety-four patients with fever 60 healthy volunteers were included study. Of patients, 12 had related amyloidosis. was obtained from hematology laboratory archive. >Results</i>. significantly higher among persons compared individuals (<svg...

The aim of the current study was to investigate protective effect naringin on bleomycin-induced pulmonary fibrosis in rats. Twenty-four Wistar rats randomly divided into four groups (control, bleomycin alone, + 40, and 80) were used. Rats administered a single dose (5 mg/kg; via tracheal cannula) alone or followed by either 40 mg/kg (orally) 80 water (1 mL, orally) for 14 days. lung tissue weighed determine index. TNF- α IL-1 β levels, hydroxyproline content, malondialdehyde (MDA) levels...

The aim of this study was to determine the levels plasma pregnancy-associated protein-A (PAPP-A) and C-reactive protein (CRP) in pre-eclampsia their association with mean arterial blood pressure (MAP).Sixty-seven women symptoms were matched 56 normal pregnant controls for gestational age, maternal age parity. Both groups third trimester. PAPP-A CRP measured serum using chemiluminescence assay nephelometry, respectively.Maternal increased compared controls. There significant correlations...

Oxidative stress is a complicated process, which was defined as an increase in prooxidants and decrease antioxidants caused by various mechanisms, including inflammation surgical trauma. The association between acute appendicitis oxidative has been showed previous studies. However, comparison of laparoscopic or open appendectomy (OA) not established.Patients who were diagnosed October 2012 January 2013 randomized to (OA, n = 50) (LA, 50). Blood samples for markers (total oxidant status [TOS]...

Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease with high mortality rate. In clinical practice, we observed bradycardia in some pediatric patients CCHF during the course. So aimed to report cases that presented course and relation of findings ribavirin therapy.Charts all hospitalized were reviewed respect age, sex, history tick bite or removing tick, other risk factors for transmission, interval between onset symptoms. Outcomes laboratory medications recorded each patient....

[6][7][8][9] The pathophysiological mechanism of such remote organ injury in severe burn remains unclear.11][12][13][14] proinflammatory effects ROS and RNS include endothelial damage, neutrophil reinforcement, cytokine release, mitochondrial injury.Thus, following appears to be mediated by via the formation oxidative nitrosative stress as a consequence inflammatory response. [1,9,15,16]

Insulin resistance (IR) is one of the most important etiological risk factors in development diabetes. However, there no clear data regarding prevalence IR country.This study evaluates and identifies optimal threshold values for HOMA indexes Turkey.This cross-sectional, population-based survey includes 2013 participants aged 20-84 years. The anthropometric measurements laboratory analysis were recorded. 90th percentile non-obese non-diabetic population was accepted as cut-off IR.The 2.46...

Background Serum amyloid A (SAA), which is produced in the liver, acts as an apoprotein of high‐density lipoprotein (HDL) accumulation extracellular matrix tissues and organs. SAA elevations play a significant role development amyloidosis. Microalbuminuria (MAU) early period amyloidosis patients with familial Mediterranean fever (FMF). We assessed association between important factor for FMF cytokines, HDL, MAU. Methods total 40 diagnosed Tel‐Hashomer criteria making regular follow‐up visits...

Purpose The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. deterioration endoplasmic reticulum (ER) homeostasis is called ER stress. Glucose-regulated protein-78 (GRP-78) and X-box binding protein-1 (XBP-1) are key markers stress therapeutic targets diseases. Sterol regulatory element protein-1c (SREBP-1c) most important transcription factor that regulates expression enzymes for fatty acid synthesis. purpose this paper to research L-carnitine trans-chalcone...

Acute kidney injury is an important issue in chemotherapy receiving patients neutrophil gelatinase-associated lipocalin has been proposed as a novel marker. We here aimed to assess the role of urinary levels for assessment after platin exposure.Patients who had treated with cisplatin or carboplatin oxaliplatin containg regimens were included this study. Baseline and postchemotherapy serum urea, creatinine, urine creatinine determined. To avoid effects hydration during infusion...

Background: Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators apoptosis. The aim this study the evaluation Crimean-Congo hemorrhagic fever (CCHF) disease changes levels these apoptotic markers relation with severity. Methods: Forty-nine hospitalized children CCHF 36 healthy controls were enrolled prospective study. patients classified into 2...

Crimean–Congo haemorrhagic fever (CCHF) is a disease with severe course including acute viral fever, ecchymosis, thrombocytopenia, hepatic function disorder and high mortality. Myeloperoxidase (MPO) an enzyme located in neutrophil granulocytes plays important role the destruction of phagocytosed micro-organisms. The aim this study was to analyse MPO activity CCHF cases compared control group. A total 47 randomly selected patients admitted Department Infectious Diseases Cumhuriyet University...

We aimed to assess the association between serum levels of soluble IL-2 receptor (sIL-2r) and endothelin-1 severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Fifty-two patients under 18 years age a laboratory- confirmed diagnosis CCHF 38 healthy controls were enrolled study. Patients classified into two groups based on disease severity (severe group non-severe group). The sIL-2r observed be significantly higher compared those control (p < 0.05). In addition, also found...

Crimean-Congo hemorrhagic fever (CCHF) causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining vascular integrity, growth factor (VEGF-A) its receptor (VEGFR1) angiopoietin-2 (Ang-2) (Tie-2) are very important mediators. For this reason, we aimed at studying association of Ang-2 VEGF their receptors Tie-2 VEGFR1 with CCHF infection.Thirty one patients 31 healthy controls (HC) were included in study. classified into 2 groups terms...

Background Polycystic ovary syndrome (PCOS) is a frequent reproductive and metabolic disorder associated with insulin resistance. Recently, angiopoietins were identified in the systemic circulation have been designated angiopoietinlike proteins (ANGPTL). More recently, it shown that angiopoietin-related growth factor (AGF, also called ANGPTL6) directly regulate lipid, glucose, energy metabolism independent of angiogenic effects animal studies. The aim this study was to determine whether...