A5082023896- Chronic Obstructive Pulmonary Disease (COPD) Research
- Human Health and Disease
- Hydrogen's biological and therapeutic effects
- Asthma and respiratory diseases
- High Altitude and Hypoxia
- Metabolomics and Mass Spectrometry Studies
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- S100 Proteins and Annexins
- Cardiovascular Health and Risk Factors
- Eicosanoids and Hypertension Pharmacology
Ryazan State Medical University named after Academician I.P. Pavlov
2016-2023
Рязанский государственный медицинский университет имени
Aim. To study the concentration of succinate and activity dehydrogenase (SDH) mononuclear blood leukocytes as markers rapid adaptation mitochondria to hypoxia in patients with exacerbation chronic obstructive pulmonary disease (COPD).
 Materials Methods. The involved 58 COPD 13 conventionally healthy volunteers 40-75 years age. In accordance GOLD 2018 principles complex assessment, were divided groups B (n=18), C (n=20), D (n=20) comparable age, FEV1 pack-of-cigarettes/year index....
Проблема коморбидности приобретает все большую актуальность в клинической практике.С каждым годом растет популяция больных с сочетанной патологией.Закономерно увеличение количества заболеваний у одного пациента старшей возрастной группе.Под «коморбидностью» подразумевают наличие больного двух взаимосвязанных заболеваний.При патологии неоспорима необходимость изучения особенностей патогенетического взаимодействия заболеваний, внедрения новых методов диагностики, разработка индивидуальных...
Bronchial asthma and chronic obstructive pulmonary disease are the most common diseases of respiratory system. 230 million people suffer from disease, bronchial - 300 worldwide. Annually 200-300 in Europe 2.74 world population die 250 thousand a year. The social economic significance these determine need for in-depth study their combination same patient. Each has its own phenotypes, but 10-20% patients, there symptoms both asthma. In spite clear diagnostic criteria, some cases it is...
INTRODUCTION: Patients with chronic obstructive pulmonary disease (COPD) have a characteristic problem of comorbid and combined pathology, which impedes the objective assessment severity patients’ condition. Of special attention is COPD in patients overweigh obesity, since adipose tissue not only worsens dysfunction, but indirectly enhances oxidative damage to cells, especially hypoxic conditions. Therefore, level markers that directly characterize degree distress, interesting as possible...
Aim. To study the indicators of energy metabolism and oxidative stress in mononuclear leukocytes peripheral blood to assess possibility mitochondrial dysfunction development chronic obstructive pulmonary disease bronchitis.
 Methods. The included 50 patients aged 40 75 years with (COPD) or bronchitis. first group 13 In accordance GOLD spirometric classification, second third groups COPD moderate severity (COPD 2) (n=17) severe 3) (n=20) respectively. isolated leukocytes, activity...
Background. Chronic obstructive pulmonary disease and bronchial asthma, when combined in one patient, are characterized by a low level of control. Excess weight aggravates the course diseases. The study features this syntropy will improve effectiveness therapeutic measures. Aim. cytokines carbonylated proteins patients with combination asthma chronic overweight normal during an exacerbation. Material methods. included 136 people: first group (n=30), second (n=36), third (n=29), fourth...
<b>Introduction:</b> The increase in the incidence of bronchial asthma, COPD and obesity causes a high probability their combination one patient. activity systemic inflammation each diseases is able to modify clinical picture, which makes assessment effect excess body weight on level markers patients with asthma-COPD overlap (ACO) relevant. <b>Aim:</b> To estimate pro-inflammatory cytokines ACO normal during exacerbation disease. <b>Methods:</b> study included 30 period, (mean age 60.5±4.7),...