A5072893271- Cancer, Hypoxia, and Metabolism
- Protein Structure and Dynamics
- Mitochondrial Function and Pathology
- Connexins and lens biology
- Biochemical effects in animals
- Enzyme Structure and Function
- Cell death mechanisms and regulation
- ATP Synthase and ATPases Research
- Heat shock proteins research
- Yersinia bacterium, plague, ectoparasites research
- Microtubule and mitosis dynamics
- Carbon Nanotubes in Composites
- Gene expression and cancer classification
- Graphene research and applications
- X-ray Diffraction in Crystallography
- Hippo pathway signaling and YAP/TAZ
- Enzyme Catalysis and Immobilization
- Alzheimer's disease research and treatments
- South Asian Cinema and Culture
- Protein Interaction Studies and Fluorescence Analysis
- Advancements in Battery Materials
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
Indian Institute of Chemical Biology
2021-2025
Indian Institute of Technology Gandhinagar
2019-2024
Persistence of drug-resistant breast cancer stem cells (brCSCs) after a chemotherapeutic regime correlates with disease recurrence and elevated mortality. Therefore, deciphering mechanisms that dictate their phenotype is imperative for designing targeted more effective therapeutic strategies. The transcription factor SOX2 has been recognized as protagonist in brCSC maintenance, previous studies have confirmed inhibition purportedly eliminated these brCSCs. However, pharmacological targeting...
Abstract The anti‐apoptotic proteins, Bcl‐2 and Survivin, are consistently overexpressed in numerous human malignancies, notably colorectal cancer. 2,4‐Di‐tert‐butylphenol (2,4‐DTBP) is a naturally occurring phenolic compound known for its diverse biological activities, including anti‐cancer properties. mechanism behind 2,4‐DTBP‐induced inhibition of cell proliferation apoptosis cancer cells, specifically regarding remains to be elucidated. In this study, we employed both silico vitro...
Carbon nanotubes have been explored in various fields of science and technology due to their unique properties. However, toxic nature put limitations its consideration for the bio-medical applications. In our work, we report synthesis paramagnetic CNT/Gd2O3 hybrid nanostructures through easily scalable electrochemical deposition technique. The nanostructure has shown significant longitudinal relaxivity 18.93 mM−1s−1 water protons indicating possibility be used as an MRI contrast agent....
Ovarian cancer has sustained as a major cause of cancer-related female mortality owing to its aggressive nature and dearth early detection markers. Ets1 oncoprotein, transcription factor belonging the Ets family, is well-established promoter epithelial mesenchymal transition (EMT) prospective malignancy marker in ovarian cancer. Our study establishes regulator mitochondrial fission-fusion dynamics through Drp1 augmentation via direct binding at DNM1L (DRP1) promoter. overexpression-mediated...
Mitochondrion, the powerhouse of cells, has emerged as one unorthodox targets in anticancer therapy due to its involvement several cellular functions. However, development small molecules for selective mitochondrial damage cancer cells remained limited and less explored. To address this, our work, we have synthesized a natural product inspired cyanine-based 3-methoxy pyrrole molecule library by concise strategy. This strategy involves Vilsmeier Pd(0) catalyzed Suzuki cross-coupling reactions...
Protein folding is a very complex process and, so far, the mechanism of still intrigues research community.
Cataracts, a major cause of global blindness, contribute significantly to the overall prevalence blindness. The opacification lens, resulting in cataract formation, primarily occurs due aggregation crystallin proteins within eye lens. Despite high concentration these crystallins, they remarkably maintain lens transparency and refractive index. α-Crystallins (α-crys), acting as chaperones, play crucial role preventing aggregation, although exact molecular mechanism remains uncertain. In this...
Reduced activity of enzymes upon immobilization is a major challenge for the industrial use enzymes. Enzyme–surface interactions and between immobilized are thought as primary reasons reduced activity. In current paper, we study thermal structural stability proteins on patterned hydrophobic surface in framework hydrophobic–polar lattice model. Our results indicate that, while homogeneous denatures proteins, carefully surfaces can dramatically increase adsorbed proteins. The size, shape,...
Interprotein interactions between the partially unfolded states of γD-crystallin (γD-crys) protein are known to cause cataracts. Therefore, understanding unfolding pathways native γD-crys is extremely crucial delineate their aggregation mechanism. In this study, we have performed extensive all-atom Molecular Dynamics simulations with explicit solvent understand role critical residues that drive stability motifs and domains in its wild type mutant forms. Our findings show while individual not...
Carbon nanotubes have been explored in various fields of science and technology due to their unique properties. However, toxic nature put limitations its consideration for the bio-medical applications. In our work, we report synthesis paramagnetic CNT/Gd2O3 hybrid nanostructures through easily scalable electrochemical deposition technique. The longitudinal relaxivity has estimated be 18.93 mM-1s-1 from NMR studies indicating possibility used as an MRI contrast agent. in-vitro cytotoxicity...