A5020403470- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Immunotherapy and Immune Responses
- Radiation Therapy and Dosimetry
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Nuclear and radioactivity studies
- Nuclear Issues and Defense
- Cancer Cells and Metastasis
- Radioactive contamination and transfer
- Polymer Surface Interaction Studies
- Occupational exposure and asthma
- Mining and Gasification Technologies
- Sulfur Compounds in Biology
- Dendrimers and Hyperbranched Polymers
- Photodynamic Therapy Research Studies
- Air Quality and Health Impacts
- Tree Root and Stability Studies
- Seedling growth and survival studies
- Carcinogens and Genotoxicity Assessment
- Soil Mechanics and Vehicle Dynamics
- Neonatal Respiratory Health Research
Yamaguchi University
2020-2024
Kyoto University
2022
Thiol-organosilica nanoparticles that are internally functionalized with IR-820 (thiol-OS/IR820) were prepared via a one-pot process for near-infrared (NIR) fluorescence in vivo imaging. Thiol-OS/IR820 demonstrated broad-band emissive NIR multiple new fluorescent peaks differed from those of the molecule and upconversion originated thiol-OS. was biocompatible did not show significant toxicity vitro vivo. We conducted tracking situ labeled cells against subcutaneous xenograft cells. The...
Climatic and soil factors which affect the movement of radiostrontium in soils are discussed. A mathematical model strontium through was developed from results laboratory experiments. It is concluded that if over earth should be seriously contaminated weapon testing or radiological warfare, natural processes purification leaching would proceed at different rates areas. (C.H.)
Radiotherapy is one of the most effective cancer treatments. Au nanoparticles (NPs) are used X-ray sensitizing materials however small sub-nm size NPs for sensitizers disadvantageous cellular uptake. Here, we propose surface functionalization organosilica (OS) with (OS/Au), which combined 100 nm OS and NPs, synthesized as an sensitizer. The potential 4T1 mouse mammary tumor cells was revealed using a multifaceted evaluation fluorescence microscopic cell imaging assay. number...
Understanding of the interactions between macrophages and multifunctional nanoparticles is important for development novel macrophage-based immunotherapies. Here, we investigated effects fluorescent thiol-organosilica particle size surface properties on cell-particle interactions, including mitochondrial activity, using mouse macrophage cell line J774A.1. Three different sizes particles (150, 400, 680 nm in diameter) containing fluorescein (OS/F150, OS/F400, OS/F680) functionalized with...
In radiotherapy, the use of Au nanoparticles (Au NPs) has been proposed to enhance cell damage by X-ray irradiation. Although role in radiotherapy is not fully understood, catalytic activity actively studied industrial field. Moreover, owing their enzyme-like and high biocompatibility vitro vivo, NPs present significant potential for biological applications. this study, we incorporated different states both on surface embedded thiol-organosilica (thiol-OS/Au series) investigate efficiency...
Fluorescent silica nanoparticles (NPs) hold great promise in fluorescence microscopy (FM) owing to their high intensity and photostability, multifunctionality, biocompatibility. Conventionally, fluorescent NPs are synthesized from organic dyes or inorganic materials. This study focuses on photoluminescence (PL) exhibited by Au(I) complexes under specific conditions through a mechanism that is significantly different of the PL transition-metal complexes. Luminescent thiol-terminated...
Biomedical imaging using cell labeling is an important technique to visualize dynamics in the body. To label cells, thiol-organosilica nanoparticles (thiol-OS) containing fluorescein (thiol-OS/Flu) and rhodamine B (thiol-OS/Rho) were surface-functionalized with polyethyleneimine (PEI) (OS/Flu-PEI OS/Rho-PEI) 4 molecular weights (MWs). We hypothesized PEI structures such as brush, bent lie-down, coiled types on surface depending MWs based dynamic light scattering thermal gravimetric analyses....
Cancer cells tend to stay in the marginal sinus when they metastasize lymph nodes. This study aimed elucidate distribution of particles nodes for development novel therapeutic approaches early cancer with node metastasis. We subcutaneously administered five different sizes fluorescent thiol-organosilica (120, 380, 840, 1700, and 2800 nm) into footpads mice, observed analyzed distributions popliteal 24 h later vivo, histologically, three-dimensionally. The varied according size, measuring 120...
We investigated the distribution of intratracheally administered thiol-organosilica (thiol-OS) particles in mouse lungs. Toward this end, single doses thiol-OS containing fluorescein (140 nm diameter) (F140) and rhodamine B (Rh) (Rh160, Rh280, Rh420, Rh640, Rh1630 with diameters 160, 280, 420, 640, 1630 nm, respectively) were administered. After 24 h, fluorescence imaging revealed homogeneous a patchier pattern on lung surface no difference among six particle sizes. Simultaneous dual...
Fetal bovine serum (FBS) particles, which mainly consist of albumin, have the potential for biological and medical applications as drug carriers. The coacervation albumin is a common technique preparing albumin-based particles. replacement salt with novel metal salts such Cu an affordable way to embed ion in Further, increased distribution prevalent many cancers. Here, we prepared adhesive cell-like FBS-copper phosphate hybrid particles [FBS-Cu3(PO4)2], exhibited toxicity toward cancer...
Abstract Radiotherapy is one of the most effective cancer treatments. Au nanoparticles (NPs) are used X-ray sensitizing materials however small sub-nm size NPs for sensitizers disadvantageous cellular uptake. Here, we propose surface functionalization organosilica (OS) with (OS/Au), which combined 100 nm OS and NPs, synthesized as an sensitizer. The potential 4T1 mouse mammary tumor cells was revealed using a multifaceted evaluation fluorescence microscopic cell imaging assay. number...