A5040846908- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Child Nutrition and Feeding Issues
- Child Nutrition and Water Access
- Emergency and Acute Care Studies
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Congenital Heart Disease Studies
- Autoimmune and Inflammatory Disorders Research
- Energy, Environment, and Transportation Policies
- Food Security and Health in Diverse Populations
- Child and Adolescent Health
- Fetal and Pediatric Neurological Disorders
- Acute Lymphoblastic Leukemia research
- Nutritional Studies and Diet
- Non-Invasive Vital Sign Monitoring
- Adolescent and Pediatric Healthcare
- Statistical Methods and Inference
- Healthcare Technology and Patient Monitoring
- Dental Health and Care Utilization
- Pregnancy and preeclampsia studies
- Hemodynamic Monitoring and Therapy
- Lysosomal Storage Disorders Research
- COVID-19 Pandemic Impacts
Penn State Milton S. Hershey Medical Center
2017-2024
Pennsylvania State University
2018-2023
University of Alabama at Birmingham Hospital
2022
University of Manitoba
2012-2019
Children's Hospital Research Institute of Manitoba
2012-2016
George & Fay Yee Centre for Healthcare Innovation
2015
Children's Hospital of Winnipeg
2015
Children's Hospital of Philadelphia
2010
University of Pennsylvania
2010
Sickle red cells bind significant amounts of soluble laminin, whereas normal do not. Solid phase assays demonstrate that B-CAM/LU binds laminin on intact sickle and cell immobilized another putative binding protein, CD44, does Ligand blots also identify as the only erythrocyte membrane protein(s) laminin. Finally, transfection murine erythroleukemia with human B-CAM cDNA induces both Thus, appears to be major laminin-binding protein cells. Previously reported overexpression by epithelial...
To develop and validate heart respiratory rate percentile curves for hospitalized children compare their vital sign distributions to textbook reference ranges pediatric early warning score (EWS) parameters.For this cross-sectional study, we used 6 months of nurse-documented rates from the electronic records 14,014 on general medical surgical wards at 2 tertiary-care children's hospitals. We developed using generalized additive models location, scale, shape with 67% patients validated...
We sought to describe growth in young children with congenital heart disease (CHD) over time.We performed a retrospective matched cohort study, identifying CHD large primary care network Pennsylvania, New Jersey, and Delaware matching them 10:1 control subjects. The endpoint was the difference mean World Health Organization z score for cases controls weight-for-age (WFAZ), length-for-age (LFAZ), weight-for-length (WFLZ), head circumference-for-age (HCFAZ) at traditional ages preventive...
<h3>Importance</h3> Early-life antibiotic exposure has been associated with increased adiposity in animal models, mediated through the gut microbiome. Infant is common and often inappropriate. Studies of association between infant antibiotics childhood weight gain have reported inconsistent results. <h3>Objective</h3> To assess early-life gain. <h3>Design Setting</h3> Retrospective, longitudinal study singleton births matched twin pairs conducted a network 30 pediatric primary care practices...
Large electronic health record (EHR) datasets are increasingly used to facilitate research on growth, but measurement and recording errors can lead biased results. We developed tested an automated method for identifying implausible values in pediatric EHR growth data.Using deidentified data from 46 primary care sites, we algorithm identify weight height that should be excluded analysis, including were recorded repeatedly without remeasurement. The foundation of the is a comparison each...
BACKGROUND AND OBJECTIVES Although the limitations of BMI have long been recognized, there are recent concerns that it is not a good screening tool for adiposity. We therefore examined cross-sectional relation to adiposity among 6923 8- 19-year-olds in National Health and Nutrition Survey from 2011 through 2018. METHODS Participants were scanned with dual-energy x-ray absorptiometry. Adiposity was expressed as fat mass index (FMI, kg ÷ m2) percentage body (%fat). Lean lean (LMI, m2)....
Enlargement of the subarachnoid spaces has been theorized as a risk factor for development subdural hemorrhage (SDH). As finding unexplained SDH in children often raises suspicion nonaccidental trauma, possibility increased with enlargement important clinical, social, and legal implications. Therefore, authors evaluated frequency cohort spaces.The identified younger than 2 years age who were diagnosed on MRI or CT scanning large primary care network between July 2001 January 2008. The...
There have been conflicting reports concerning weight gain among adults during the COVID-19 epidemic. Although early studies reported large increases, several of these analyses were based on convenience samples or self-reported information. The objective current study is to examine pandemic-related increase associated with pandemic through May 2021.A total 4.25 million (18 84 years) in an electronic health record database who had at least two measurements between January 2019 and February...
Heart rate (HR) is frequently used by clinicians in the hospital to assess a patient's severity of illness and make treatment decisions. We sought develop percentiles that characterize relationship expected HR age body temperature hospitalized children compare these with published references both primary care emergency department (ED) settings.Vital sign data were extracted from electronic health records inpatients <18 years at 2 large freestanding children's hospitals July 2011 June 2012....
To compare currently available head-circumference growth curves to constructed from clinical measurements patients in a large US primary care network (PCN).We performed retrospective cohort study of 75 412 an urban-suburban PCN. Patients with birth weight <1500 g or gestational age <33 weeks at were excluded. We compared percentile values and the proportion observations above 95th below 5th for existing PCN curves.The most similar National Center Health Statistics (NCHS) substantially...
The test characteristics of head circumference (HC) measurement percentile criteria for the identification previously undetected pathology associated with enlargement in primary care are unknown. Electronic patient records were reviewed to identify children age 3 days years new diagnoses intracranial expansive conditions (IEC) and metabolic genetic macrocephaly (MGCM). We tested following HC threshold criteria: ever above 95th, 97th, or 99.6th crossing 2, 4, 6 increasing major lines. Centers...
Associations between body mass index (BMI) and caries have been reported.To evaluate the direction of relationship BMI severe early childhood (S-ECC).Children were recruited as part a larger prospective cohort study assessing changes in nutritional status following dental rehabilitation under general anaesthetic. Pre-operative anthropometric measurements used to calculate z-scores (BMIz). Operative reports reviewed scores based on treatment rendered. Analysis included descriptive statistics,...
Abstract Background Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment modifying anti-rheumatic drugs (DMARDs). IAS offer an opportunity to recapture control and avoid exposure side effects from immunosuppression. We examined cohort patients treated after report the probability restarting within 12 months. Methods analyzed Childhood Arthritis...
Objective To compare the proportion of female and male fetuses classified as microcephalic (head circumference [HC] &lt; 3rd percentile) macrocephalic (&gt;97th by commonly used sex-neutral growth curves. Methods For evaluated at a single center, we retrospectively determined percentile first fetal HC measurement between 16 0/7 21–6/7 weeks using Hadlock, Intergrowth-21st, NICHD The association sex likelihood being or was with logistic regression. Results Female ( n = 3,006) were...
Children with single ventricle cardiac disease (SVCD) have poor growth in early life. Tube-assisted feeding (TF) is used to improve weight gain, but its impact on long-term remains unknown. We sought compare the longitudinal of SVCD patients receiving TF after initial surgery those fed entirely by mouth.We conducted a retrospective cohort study who underwent surgical palliation between 1999 and 2009. defined as use nasogastric, gastrostomy, or jejunostomy TF. compared maximal attained...
Objective: The beginning of postinfancy increase in BMI has been termed the adiposity rebound, and an early rebound increases risk for obesity adolescence adulthood. We examined whether relation age at (agerebound) to subsequent is independent childhood BMI. Design: From electronic health records 2.8 million children, we selected 17,077 children least once each year between ages 2 <8 years, who were reexamined 10 <16 years. mean last visit was 12 years (SD = 1). identified agerebound child...
Abstract This work presents a new approach, called Multiple Imputation of Sparsely-sampled Functions at Irregular Times (MISFIT), for fitting generalized functional linear regression models with sparsely and irregularly sampled data. Current methods do not allow consistent estimation unless one assumes that the number observed points per curve grows sufficiently quickly sample size. In contrast, MISFIT is based on multiple imputation framework, which, as we demonstrate empirically, has...
The patient is a term 6-month-old male, who presented with failure to thrive since birth. History was remarkable for suspected milk and soy protein allergy, gastroesophageal reflux, constipation, abdominal distension that present He losing weight despite oral intake of over 100 kcal/kg per day. Prior workup including laboratory studies, X-ray, upper gastrointestinal series fluoroscopy, barium enema, ultrasound were all within normal limits. patient's history, diagnostic evaluation, final...
Sudden unexpected infant death often results from unsafe sleep environments and is the leading cause of postneonatal mortality in United States. Standardization environment education has been revealed to impact such deaths. This standardized approach similar safety prevention bundles typically used monitor improve health outcomes, as those related hospital-acquired conditions (HACs). We sought use HAC model measure adherence safe guidelines an entire children's hospital.A hospital-wide...