A5033557670- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Signaling Pathways in Disease
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Chromatin Remodeling and Cancer
- Skin Protection and Aging
- Food Allergy and Anaphylaxis Research
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Vitamin D Research Studies
- Plant responses to water stress
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive System and Pregnancy
- Circadian rhythm and melatonin
- Genetic Associations and Epidemiology
- Plant Water Relations and Carbon Dynamics
- interferon and immune responses
Cincinnati Children's Hospital Medical Center
2020-2024
University of Cincinnati Medical Center
2020-2024
University of Cincinnati
2022-2024
Children’s Institute
2023
University of Wyoming
2017-2018
Climate models predict widespread increases in both drought intensity and duration the next decades. Although water deficiency is a significant determinant of plant survival, limited understanding responses to extreme impedes forecasts forest crop productivity under increasing aridity. Drought induces suite physiological responses; however, we lack an accurate mechanistic description response lethal that would improve predictive mortality altered climate conditions. Here, proxies for leaf...
Atopic dermatitis (AD) is a chronic inflammatory skin disease that often precedes the development of food allergy, asthma, and allergic rhinitis. The prevailing paradigm holds reduced frequency function natural killer (NK) cell contributes to AD pathogenesis, yet underlying mechanisms contributions NK cells comorbidities remain ill-defined. Here, analysis circulating in longitudinal early life cohort children with revealed progressive accumulation low expression activating receptor NKG2D,...
Peptidylarginine deiminase (PAD) enzymes convert histone arginine residues into citrulline to modulate chromatin organization and gene expression. Although PADs are expressed in anterior pituitary gland cells, their functional role expression adenomas unknown. To begin address these issues, we first examined normal human pituitaries found that PAD2, PAD4, citrullinated histones highest prolactinomas somatoprolactinomas. In the somatoprolactinoma-derived GH3 cell line, citrullinate H3, which...
Peptidylarginine deiminases (PADs or PADIs) catalyze the conversion of positively charged arginine to neutral citrulline, which alters target protein structure and function. Our previous work established that gonadotropin-releasing hormone agonist (GnRHa) stimulates PAD2-catalyzed histone citrullination epigenetically regulate gonadotropin gene expression in gonadotrope-derived LβT2 cell line. However, PADs are also found cytoplasm. Given this, we used mass spectrometry (MS) identify...
Caspase recruitment domain family member 14 (CARD14) and its variants are associated with both atopic dermatitis (AD) psoriasis, but their mechanistic impact on skin barrier homeostasis is largely unknown. CARD14 known to signal via NF-κB; however, CARD14-NF-κB signaling does not fully explain the heterogeneity of CARD14-driven disease. Here, we describe a direct interaction between MYC show that signals through in keratinocytes coordinate homeostasis. directly binds influences formation an...
Peptidylarginine deiminases (PAD) enzymes were initially characterized in uteri , but since then little research has examined their function this tissue. PADs post-translationally convert arginine residues target proteins to citrulline and are highly expressed ovine caruncle epithelia uterine luminal epithelial (OLE)-derived cell line. Progesterone (P4) not only maintains the also regulates expression of endometrial genes that code for comprise histotroph critical during early pregnancy....
Atopic dermatitis (AD) is a chronic inflammatory skin disease that often precedes the development of food allergy, asthma, and allergic rhinitis. The prevailing paradigm holds reduced frequency function natural killer (NK) cell contributes to AD pathogenesis, yet underlying mechanisms contributions NK cells comorbidities remain ill-defined. Herein, analysis circulating in longitudinal early life cohort children with revealed progressive accumulation low expression activating receptor NKG2D,...
In brief DGCR8 microprocessor complex, which is important for miRNA biogenesis, regulated by peptidylarginine deiminase 2 and expression fluctuates in gonadotrope cells across the mouse estrous cycle. Abstract Canonical biogenesis requires complex subunit, helps cleave pri-miRNAs into pre-miRNAs. Previous studies found that inhibiting (PAD) enzyme activity results increased expression. PADs are expressed cells, play a central role reproduction synthesizing secreting luteinizing follicle...
Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease that often precedes the development of food allergy, asthma, and allergic rhinitis. The prevailing paradigm holds reduced frequency function natural killer (NK) cell contributes to AD pathogenesis, yet underlying mechanisms contributions NK cells co-morbidities remain ill-defined. Herein, longitudinal analysis circulating in well-defined early life cohort children with revealed progressive accumulation low expression...
Abstract Atopic dermatitis (AD) is a common chronic inflammatory disease associated with skin barrier dysfunction. AD often precedes the development of atopic co-morbidities, including food allergy, asthma and allergic rhinitis. The contributions natural killer (NK) cells to pathogenesis progression are unclear. Peripheral blood mononuclear (PBMCs) were isolated from samples collected n=82 children participating in Mechanisms Progression Dermatitis Asthma (MPAACH) study, cohort toddlers AD....