A5023180107- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
Harvard University
2022-2023
Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso-phosphatidylinositol (lyso-PI) with arachidonyl-CoA. MBOAT7 mutations cause brain developmental disorders, and reduced expression is linked fatty liver disease. In contrast, increased hepatocellular renal cancers. The mechanistic basis of catalysis substrate selectivity are unknown. Here, we report structure a model for catalytic mechanism...
Severe burn injury induces long-lasting immune dysfunction, but the molecular mechanisms underlying this phenomenon remain unclear. We hypothesized that leads to epigenetic and transcriptional reprogramming of innate cells. Splenic F4/80⁺ macrophages were isolated from mice at days 2, 9, 14 post-20% contact injury. Targeted transcriptomics MAPit single-molecule chromatin profiling used assess immune, metabolic, changes. Canonical pathway analysis was performed infer functional shifts over...
Abstract Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane properties. Membrane-bound O -acyltransferase (MBOAT) 7 acylates lyso-phosphatidylinositol (lyso-PI) with arachidonyl-CoA. MBOAT7 mutations cause brain developmental disorders, and reduced expression is linked fatty liver disease. Further, increased hepatocellular renal cancers. The mechanistic basis of catalysis substrate selectivity are unknown. Here, we report structure a model for catalytic...