A5010456335- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Cholesterol and Lipid Metabolism
- Climate Change and Health Impacts
- Peptidase Inhibition and Analysis
- Agriculture Sustainability and Environmental Impact
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Biomedical Ethics and Regulation
- Enzyme Production and Characterization
- Cancer, Lipids, and Metabolism
- Lipid metabolism and biosynthesis
- Global Health Care Issues
- Health Systems, Economic Evaluations, Quality of Life
- Global Public Health Policies and Epidemiology
- Metabolism and Genetic Disorders
- BRCA gene mutations in cancer
- Health and Medical Research Impacts
- Science, Research, and Medicine
- Diet, Metabolism, and Disease
- Ethics in Clinical Research
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
German National Academy of Sciences Leopoldina
2015-2024
InterAcademy Partnership
2019-2024
European Council
2011-2020
University of Bonn
2019
Academy of Medical Sciences
2014
Universidad Complutense de Madrid
2014
Académie Nationale de Médecine
2014
Carol Davila University of Medicine and Pharmacy
2014
Imperial College London
2014
University College London
2014
Rat hepatocytes were incubated in monolayer culture modified Leibovitz L-15 medium containing either 10% (v/v) newborn-calf serum or 0.2% (w/v) fatty-acid-poor bovine albumin. The addition of 100 nM-dexamethasone increased the activities both phosphatidate phosphohydrolase and tyrosine aminotransferase by about 3.5-fold after 8h, these continued to rise until at least 24h. Incubating albumin-containing with 10 microM- microM-8-(4-chlorophenylthio)adenosine 3′,5′-cyclic monophosphate 2.6-...
Investigation into the mechanism of action BRL 10894 (ethyl 4-benzyloxybenzoate), a compound possessing hypolipidemic activity in rat, disclosed participation glycerolipid metabolism. In presence 10894, an abnormal metabolite was synthesized vitro using liver slices or rings small intestine with glycerol, palmitate, monoolein as substrate, and adipose tissue pyruvate substrate. Esters related chemically to other pharmacologically active acids (e.g., ibuprofen) also produced metabolites...
For the last seven years, European Academies Science Advisory Council (EASAC) has conducted a series of projects defining and clarifying priorities for policy in infectious disease. Both human animal populations are increasingly threatened by emerging re-emerging infections, including zoonoses, partly attributable to impact environmental change on distributions pathogens, hosts vectors. Among key challenges be faced climate change, increase antibiotic resistance need develop novel global...
Rat hepatocytes were incubated in monolayer culture for 8 h. Glucagon (10nM) increased the total phosphatidate phosphohydrolase activity by 1.7-fold. This effect was abolished adding cycloheximide, actinomycin D or 500 pM-insulin to incubations. The glucagon-induced increase synergistic with that produced an optimum concentration of 100 nM-dexamethasone. Theophylline (1mM) potentiated glucagon, but it did not affect dexamethasone-induced activity. relative proportion associated membranes...
Health research is essential for better public health and care. However, the use of personal data in could be put under threat by amendments recently adopted European Parliament. Individual patient records provide a vital resource benefit society. These form basis observational studies factors influencing disease help researchers identify suitable participants to invite them take part clinical trials concerning their condition. It equally make most that has already been completed. By...
1. Possible interactions between fibrin(ogen) and heparin in the control of plasminogen activation were studied model systems using thrombolytic agents tissue-type activator (t-PA), urokinase streptokinase.plasminogen complex substrates Glu- Lys-plasminogen. 2. Both t-PA activities promoted by pentosan polysulphate, but not chondroitin sulphate or hyaluronic acid. The effect was on Km. 3. In presence soluble fibrin (and its mimic, CNBr-digested fibrinogen) attenuated, although abolished....
An EASAC working group on genome editing recommends that regulators should focus specific applications of these new techniques rather than attempting to regulate itself as a technology.
The spread of COVID-19 is continuing to present enormous challenges worldwide, affecting individuals, families, communities, health services, and economies. Much now depends on curbing the pandemic, combined with gradual resumption economic social activity. Meanwhile, world in middle another crisis, climate change emergency. There a choice be made guiding recovery from COVID-19.1The LancetPost-COVID-19 spending.Lancet Planet Health. 2020; 4: e168Summary Full Text PDF PubMed Scopus (7) Google...
1. Rats were fed on diets enriched with starch, sucrose, corn oil or beef tallow for 3 weeks and the activities of various enzymes in liver measured. 2. The mitochondrial glycerol phosphate acyltransferase activity was lower rats starch diet than two high-fat diets. 3. non-microsomal (presumably peroxisomal) dihydroxyacetone higher corn-oil those sucrose beef-tallow Urate oxidase three other groups. There no significant differences acyl-CoA among 4. soluble phosphatidate phosphohydrolase not...
The progression of climate change is increasingly recognised as a emergency by international advisory bodies and governments worldwide, there are growing warnings that it will be accompanied severe health consequences.1European Academies' Science Advisory CouncilThe imperative action to protect human in Europe.https://easac.eu/publications/details/the-imperative-of-climate-action-to-protect-human-health-in-europe/Date: 2019Date accessed: July 1, 2019Google Scholar, 2Haines A Ebi K for...
Regenerative medicine has great potential. The pace of scientific advance is exciting and the medical opportunities for regeneration repair may be transformative. However, concerns continue to grow, relating problems caused both by unscrupulous private clinics offering unregulated therapies based on little or no evidence premature regulatory approval basis insufficient rationale clinical evidence. An initiative InterAcademy Partnership convened experts worldwide identify challenges, with a...
<b><i>Objective</i>—To examine the induction of antistreptokinase antibodies after giving streptokinase or anistreplase to patients with acute myocardial infarction.</b> <b><i>Design</i>—Patients were randomly allocated receive either 1·5 × 10<sup>6</sup> IU, 30U in a double blind study. Blood samples collected immediately before treatment and subsequently at intervals up 30 months; plasma assayed for resistance titre (functional assay) binding by IgG (microradioimmunoassay).</b>...
Rat hepatocytes were preincubated for 16 h with hormones or drugs and then a further 8 125I-human low-density lipoprotein (LDL). Glucagon (via cyclic AMP) adrenaline AMP alpha-effects) increased the binding of 125I-LDL to LDL receptor, degradation [125I]iodotyrosine. The effects on antagonized by dexamethasone, action was inhibited actinomycin D. results are discussed in relation control metabolism diabetes.
Summary Purified 2-chain recombinant tissue-type plasminogen activator (t-PA) was reduced under mild conditions - 10 mM dithiothreitol/ 5° C/1.5 h and the two chains were separated by chromatography on lysine Sepharose. The t-PA B chain fully active as determined its activity towards chromogenic substrate S-2288 (H-D-ile-pro-arg p-nitroanilide). Analysis sodium dodecyl sulphate polyacrylamide gel electrophoresis reducing or non-reducing revealed a single polypeptide at Mr = 35,000 29,000...
Conference Article| December 01 1981 Association between lipid-lowering activity of aryl-substituted carboxylic acids and formation substituted glycerolipids in rats ROBIN FEARS; FEARS 1Beecham Pharmaceuticals Research Division, Great Burgh, Epsom, Surrey KT18 5XQ, Walton Oaks, Tadworth, KT20 7NT, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID H. RICHARDS Biochem Soc Trans (1981) 9 (6): 572–573. https://doi.org/10.1042/bst0090572 Views Icon Article...