AbstractThe study aimed to examine the reliability and validity of Turkish version Montreal Cognitive Assessment Scale (MoCA-TR) as a screening tool for cognitive dysfunction in Parkinson's disease (PD). A total 50 patients with PD healthy controls were included. The instruments—MoCA-TR followed by Mini-Mental Status Examination (MMSE-TR) MoCA-TR retest within 1 month—and detailed neuropsychological testing administered patients. MMSE-TR also controls. discriminant validities diagnostic...

Parkinson's disease (PD) decreases the quality of life (QoL) both caregivers and patients by increasing stress burden, it has a negative impact on their psychological state. In present study, authors examined PD-patient motor non-motor clinical symptoms health, QoL Turkish caregivers. The study included 50 with PD Patients' severity disability, symptoms, complications, sleep disturbances, anxiety, depressive were assessed various scales. Data analyzed multiple linear-regression models to...

To determine the serum expression levels of seven candidate microRNAs (miRNA); miR-19a, miR-19b, miR-29a, miR-29c, miR-181, miR-195 and miR-221 in Turkish patients with Parkinson's disease (PD) explored their potential role diagnosis PD. We further described relationship between these miRNAs clinical findings treatment PD.The study included 51 PD 20 healthy controls. The severity was assessed using Hoehn Yahr staging scale Unified Disease Rating Scale (UPDRS). Venous blood samples were taken...

An increase in enviromental pollution may lead to mercury toxicity of fish origin due the accumulative nature methylmercury fish. The main sources human exposure organic compounds are contaminated and other seafoods. This descriptive study was planned determine levels anchovy hair samples from individuals with different consumption habits, evaluate those terms toxic effects. For that purpose, we analyzed 100 anchovies Black Sea Marmara, assessed 25 wholesale workers markets cleaning firm...

To investigate the predictors of suicidal ideation and attempts among Turkish Parkinson's disease (PD) patients.The study comprised 120 patients with PD. Clinical findings were obtained by using Unified Disease Rating Scale. severity was measured Hoehn Yahr staging scale, Schwab England Activities Daily Living scale used for patient disability. Psychiatric evaluation performed same psychiatrist Structured Interview Diagnostic Statistical Manual Mental Disorders (DSM-IV) Axis I Disorders....

Long noncoding RNAs (lncRNAs) are highly expressed in the brain and alterations their levels have been shown many neurodegenerative disorders. Evidence has that lncRNAs play role onset progression of Parkinson’s disease (PD) it can be used as a potential therapeutic target. Our purpose was to detect whether serum four candidate H19, GAS5, HAR1B LINC01783 related with clinical findings treatment PD or not.  . 83 patients 50 healthy controls were included this study. We assessed how...

Objective: We aimed to investigate the frequency of social phobia in patients with Parkinson’s disease (PD). In addition, we explored relationship between and clinical characteristics PD, comorbid psychiatric disorders PD patients. Methods: This study included 80 consecutive admitted Movement Disorders Clinic at Erenkoy Research Training Hospital for Neurologic Psychiatric Disorders, Istanbul, Turkey used demographic data. The were evaluated during “on state”, using Hoehn Yahr scale, Unified...

Objectives . To investigate leptin levels and their relationship to body composition demographic clinical characteristics of Turkish patients with Parkinson’s disease (PD). Patients Methods Forty eligible PD 25 healthy controls were included in the study. Body measurements (height, weight, waist circumference (WC), mass index (BMI)) whole sample findings evaluated on-state. A single 5 mL fasting blood was obtained from each participant morning. Severity using Hoehn Yahr scale Unified Disease...

To investigate the relationship between serum leptin levels and cognition in Parkinson's disease (PD) patients.Thirty patients with idiopathic PD 30 healthy controls were enrolled. At baseline, all had their standing height, weight, waist circumference measurements taken using a standard scale. Their body mass index was then calculated. A fasting blood of 5 ml obtained from each patient morning. ELISA used to analyze concentrations. The severity evaluated Hoehn Yahr scale, clinical status...

ABSTRACTABSTRACTThe authors report on three elderly patients treated with escitalopram, 10 mg/day, who presented marked sinus bradycardia. The bradycardia was clinically symptomatic or asymptomatic and disappeared within 24 hours after escitalopram discontinued. Clinicians should be cautious about cardiac effects when using a selective serotonin reuptake inhibitor in people, even at low dose.Keywords: escitaloprambradycardiaelderly

Inhalant abuse is a common occurrence and facilitated by the widespread availability of volatile solvents with legitimate commercial household uses. Freeze sprays containing chlorinated hydrocarbons such as ethyl chloride are commonly abused either sniffing directly from containers or huffing paper plastic bags that have been sprayed into. Most inhalants central nervous system (CNS) depressants. This study presents case 24-year-old woman who was diagnosed changes in her mental status,...

Atypical antipsychotics (AAPs) are approved by the US Food and Drug Administration (FDA) for treatment of schizophrenia bipolar disorder. Since health regulatory agency Canada (2002), FDA (2003), European Medicines Agency (2004) reported an increased risk cerebrovascular adverse events (CVAEs) from olanzapine risperidone in clinical trials elderly demented patients, there have been concerns about CVAEs associated with AAPs, recent guidelines emphasize importance generating evidence AAPs...

ABSTRACTA venous infarct due to cerebral thrombosis might present only with psychiatric symptoms, such as delirium, psychosis, depression, anxiety, irritability, lack of interest, personality change, apathy/abulia or cognitive deterioration. This condition be difficult diagnose on clinical grounds alone. Radiological studies are crucial for establishing a definitive diagnosis. Non-invasive magnetic resonance imaging combined venography and without contrast is the most sensitive diagnostic...

Even though drivers with Parkinson's disease (PD) are considered at higher for accidents due to associated visual, cognitive impairments as well sleeping and movement disorders, no epidemiologic relationship between PD has been established.However, have found cease driving earlier than healthy controls of similar age.The medical diagnosis or the physician's evaluation alone is not enough decide fitness in PD.Evaluation movement, visual skills traffic simulation tests help assess performance,...

Abstract Purpose To investigate the potential of magnetic resonance imaging (MRI)‐based total and segmental hippocampus volume analysis in assessment cognitive status Parkinson's disease (PD). Methods We divided participants into three groups Group A‐Parkinson patients (Pp) with normal ( n = 25), B‐Pp dementia 17), C‐healthy controls 37). Three‐dimensional T1W Fast Spoiled Gradient Recalled Echo images were used for Volbrain subfield segmentation. “Winterburn” protocol, which divides five...

Objectives: The aim of the study was to investigate serum plasminogen activator inhibitor-1 (PAI-1) levels patients with Parkinson’s disease (PD) and their relationship clinical findings treatment disease. Methods: included 125 PD 48 healthy controls. Patients have been taking effective dopaminergic regularly. severity parkinsonism assessed using Hoehn Yahr (HY) staging scale Unified Rating Scale (UPDRS). PAI-1 level analysis performed by enzyme-linked immunosorbent assay. Results: had...

Amaç: Parkinson hastalığı (PH) olan hastalara bakım verenler yoğun psikolojik stres yaşarlar.Bu çalışmada Belirti Tarama Ölçeği 90 (SCL-90-R) formu kullanılarak, PH'li bakmanın, verenlerin psikiyatrik durumları üzerindeki etkisi araştırılmış ve değişik sosyo-demografik klinik özellikler ile verenin yaşadığı arasındaki ilişki açıklanmaya çalışılmıştır

Low density lipoprotein receptor-related protein-1 (LRP-1) is highly expressed in the central nervous system and plays a role neurodegenerative disorders. The available data on this subject-matter seem to support presence of correlation between LRP-1 levels abnormal aggregation plurality proteins, including tau, amyloid, α‑synuclein. Understanding molecular mechanisms underlying Parkinson's disease (PD) critical for development new therapies.

Ozdilek B, Uluc K, Gunal DI. Bilateral striopallidodentate calcinosis presenting with psychiatric symptoms and speech disorders. Background : (BSPDC), also known as Fahr's disease, is a rare neurodegenerative disorder characterised by the deposition of calcium other minerals in basal ganglia, centrum semiovale cerebellum. It usually idiopathic. Its clinical manifestations vary from asymptomatic individuals to neuropsychiatric abnormalities, movement disorders, cerebellar cognitive...