A5080428017- DNA Repair Mechanisms
- Immune cells in cancer
- Inflammation biomarkers and pathways
- Epigenetics and DNA Methylation
- Macrophage Migration Inhibitory Factor
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- Telomeres, Telomerase, and Senescence
- Renal and related cancers
- Immune responses and vaccinations
- Computational Drug Discovery Methods
- Genetics, Aging, and Longevity in Model Organisms
- Plant Genetic and Mutation Studies
- Biochemical and Molecular Research
- ATP Synthase and ATPases Research
- Cancer-related gene regulation
University of North Texas
2018-2024
Truman State University
2023
The University of Texas at Dallas
2022
Abstract Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at increased risk developing hematopoietic malignancies. Here, we describe a novel animal model carrying recurrent TET2 missense mutation frequently found in patients and leukemia. In fashion similar to CH, animals show signs disease late life when they develop wide range myeloid neoplasms, including acute leukemia (AML). Using...
Enzymes of the ten-eleven translocation (TET) family add diversity to repertoire nucleobase modifications by catalyzing oxidation 5-methylcytosine (5mC). TET enzymes were initially found oxidize 5-methyl-2'-deoxycytidine in genomic DNA, yielding products that contribute epigenetic regulation mammalian cells, but have since been also 5-methylcytidine RNA. Considering different configurations single-stranded (ss) and double-stranded (ds) DNA RNA coexist a cell, defining scope TET's preferred...
Remdesivir was the first antiviral drug that received emergency use authorization from United States Food and Drug Administration is now formally approved to treat COVID-19. a nucleotide analogue targets RNA-dependent RNA polymerase (RdRp) of coronaviruses, including SARS-CoV-2. The solution multiple RdRp structures has been one main axes research in race against SARS-CoV-2 virus. Several hypotheses mechanism inhibition by remdesivir have proposed, although open questions remain. This work...
Selection of residues and other molecular fragments for inclusion in the quantum mechanics (QM) region QM/molecular (MM) simulations is an important step these calculations. Here, we present approach that combines protein sequence/structure evolution electron localization function (ELF) analyses. The combination two analyses allows determination whether a residue needs to be included QM subsystem or can represented by MM environment. We have applied this on systems previously investigated...
Specialized DNA damage-bypass Y-family polymerases contribute to cancer prevention by providing cellular tolerance damage that can lead mutations and progression increasing genomic instability. also bypass adducts caused chemotherapy agents. One of the four human polymerases, polymerase (pol) κ, has been shown be specific for minor groove inhibited major adducts. In addition, in gene encoding pol κ are associated with different types cancers as well responses. We characterized nine variants...
Pathogenic germline variants in the protection of telomeres 1 gene (POT1) have been associated with predisposition to a range tumour types, including melanoma, glioma, leukaemia and cardiac angiosarcoma. We sequenced all coding exons POT1 2928 European-descent melanoma cases 3298 controls, identifying 43 protein-changing genetic variants. performed POT1-telomere binding assays for missense stop-gained variants, finding nine that impair or disrupt protein-telomere complex formation, we...
Human polymerases are vital for genetic information management. Their function involves catalyzing the synthesis of DNA strands with unparalleled accuracy, which ensures fidelity and stability human genomic blueprint. Several disease-associated mutations their functional impact on have been reported. One particular polymerase, polymerase kappa (Pol κ), has reported to be susceptible several cancer-associated mutations. The Y432S mutation in Pol κ, is associated various cancers, interest due...
Human DNA polymerases are vital for genetic information management. Their function involves catalyzing the synthesis of strands with unparalleled accuracy, which ensures fidelity and stability human genomic blueprint. Several disease-associated mutations their functional impact on have been reported. One particular polymerase, polymerase kappa (Pol κ), has reported to be susceptible several cancer-associated mutations. The Y432S mutation in Pol κ, associated various cancers, is interest due...
Remdesivir was the first antiviral drug that received emergency use authorization from United States Food and Drug Administration is now formally approved to treat COVID-19. a nucleotide analogue targets RNA-dependent RNA polymerase (RdRp) of coronaviruses, including SARS-CoV-2. The solution multiple RdRp structures has been one main axes research in race against SARS-CoV-2 virus. Several hypotheses mechanism inhibition by remdesivir have proposed, although open questions remain. This work...
We present an approach that combines protein sequence/structure evolution and electron localization function (ELF) analyses. The combination of these two analysis allows the determination whether a residue needs to be included in QM subsystem, or can represented by MM environment. have applied this on systems previously investigated QM/MM simulations, 4{oxalocrotonate tautomerase (4OT), ten-eleven translocation-2 (TET2), provide examples where fragments may not need subsystem. Subsequently,...
We present an approach that combines protein sequence/structure evolution and electron localization function (ELF) analyses. The combination of these two analysis allows the determination whether a residue needs to be included in QM subsystem, or can represented by MM environment. have applied this on systems previously investigated QM/MM simulations, 4{oxalocrotonate tautomerase (4OT), ten-eleven translocation-2 (TET2), provide examples where fragments may not need subsystem. Subsequently,...
<div>Abstract<p>Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at increased risk developing hematopoietic malignancies. Here, we describe a novel animal model carrying recurrent TET2 missense mutation frequently found in patients and leukemia. In fashion similar to CH, animals show signs disease late life when they develop wide range myeloid neoplasms, including acute leukemia...
Supplementary Figure from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Supplementary Figure from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Supplementary Data from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Supplementary Data from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
<div>Abstract<p>Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at increased risk developing hematopoietic malignancies. Here, we describe a novel animal model carrying recurrent TET2 missense mutation frequently found in patients and leukemia. In fashion similar to CH, animals show signs disease late life when they develop wide range myeloid neoplasms, including acute leukemia...
Cancer is one of the leading causes death in U.S., and tumorous cancers such as cervical, lung, breast, ovarian are most common types. APOBEC3B a nonessential cytidine deaminase found humans theorized to defend against viral infection. However, overexpression linked cancer humans, which makes potential treatment target through competitive inhibition for several cancers. Computational studies can help reveal small molecule inhibitor using high-throughput virtual screening millions candidates...
Remdesivir was the first antiviral drug that received emergency use authorization from United States Food and Drug Administration to treat COVID-19. is a nucleotide analogue targets RNA-dependent RNA polymerase (RdRp) of coronaviruses, including SARS-CoV-2. The solution multiple RdRp structures has been one main axes research in race against SARS-CoV-2 virus. Several hypotheses mechanism inhibition by remdesivir have proposed, although open questions remain. This work explores impact up four...
Abstract Pathogenic germline variants in the protection of telomeres 1 gene ( POT1 ) have been associated with predisposition to a range tumor types, including melanoma, glioma, leukemia and cardioangiosarcoma. We sequenced all coding exons 2,929 European-descent melanoma cases 3,298 controls, identifying 43 protein-changing genetic variants. performed POT1-telomere binding assays for missense stop gained variants, finding nine that impair or disrupt protein-telomere complex formation, we...
Abstract The prediction of protein mutations that affect function may be exploited for multiple uses. In the context disease variants, compensatory reestablish functional phenotypes could aid in development genetic therapies. this work, we present an integrated approach combines coevolutionary analysis and molecular dynamics (MD) simulations to discover mutations. This is employed investigate possible rescue a poly(ADP-ribose) polymerase 1 (PARP1) variant, PARP1 V762A, associated with lung...