A5003906062- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Microtubule and mitosis dynamics
- Inflammation biomarkers and pathways
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fungal and yeast genetics research
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Acute Lymphoblastic Leukemia research
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
New York University
2014-2024
Spanish National Cancer Research Centre
2010-2022
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2016-2022
Howard Hughes Medical Institute
2014-2016
University School
2015
Centro de Investigación del Cáncer
2011-2012
Abstract Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at increased risk developing hematopoietic malignancies. Here, we describe a novel animal model carrying recurrent TET2 missense mutation frequently found in patients and leukemia. In fashion similar to CH, animals show signs disease late life when they develop wide range myeloid neoplasms, including acute leukemia (AML). Using...
Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance differentiation. Here we characterize the role Ddb1, a component CUL4-DDB1 ubiquitin ligase complex. Ddb1 highly expressed in multipotent hematopoietic progenitors its deletion leads to abrogation both fetal hematopoiesis, targeting specifically transiently amplifying progenitor subsets. However, non-dividing lymphocytes has no discernible phenotypes. silencing activates Trp53 pathway significant...
Cdc14 is an essential phosphatase in yeast but its role the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple regulators resulting early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at C-terminal domain (CTD) RNA polymerase II, a major substrate cyclin-dependent kinases. Lack results increased CTD-Ser5 phosphorylation, epigenetic modifications mark active chromatin, transcriptional...
AbstractCdc14 is a dual-specific phosphatase with relevant functions during mitotic exit in yeast. The relevance of vertebrate Cdc14 phosphatases not well understood due to the presence two paralogs, Cdc14A and Cdc14B, their dispensability for cell cycle progression. Here, we report that overexpression mammalian but Cdc14A, leads dramatic changes morphology malignant transformation normal murine fibroblasts. Cdc14B disrupts cytoskeletal F-actin organization loss actin stress fibers vinculin...
ABSTRACT Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions systemic responses are poorly understood. Here, we leveraged a highly compartmentalized model of skin and identified surprising type I interferon (IFN)- mediated activation hematopoietic stem/progenitor cells (HSPCs) that results in profound changes to host responses. Post-inflamed mice were protected from atherosclerosis had worse outcomes...
<div>Abstract<p>Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at increased risk developing hematopoietic malignancies. Here, we describe a novel animal model carrying recurrent TET2 missense mutation frequently found in patients and leukemia. In fashion similar to CH, animals show signs disease late life when they develop wide range myeloid neoplasms, including acute leukemia...
Supplementary Figure from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Supplementary Figure from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Supplementary Data from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
Supplementary Data from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
<div>Abstract<p>Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of mutated preleukemic cells. Individuals with CH are at increased risk developing hematopoietic malignancies. Here, we describe a novel animal model carrying recurrent TET2 missense mutation frequently found in patients and leukemia. In fashion similar to CH, animals show signs disease late life when they develop wide range myeloid neoplasms, including acute leukemia...