A5063987448- MicroRNA in disease regulation
- Organizational Management and Innovation
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Innovation and Knowledge Management
- Cellular Mechanics and Interactions
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Business Strategy and Innovation
- Chronic Myeloid Leukemia Treatments
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Advanced Breast Cancer Therapies
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Family Business Performance and Succession
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Corporate Finance and Governance
- Peroxisome Proliferator-Activated Receptors
- Lung Cancer Treatments and Mutations
- Eating Disorders and Behaviors
- Epigenetics and DNA Methylation
- Organizational Downsizing and Restructuring
Spanish National Cancer Research Centre
2015-2024
Centro de Investigación del Cáncer
2011-2024
Cancer Research Center
2023-2024
Ibero-American University Puebla
2024
Ibero American University
2024
Hospital Universitario La Paz
2008-2024
Centro de Biología Molecular Severo Ochoa
2008-2016
Universidad Autónoma de Madrid
2008-2016
Universidad de Salamanca
2006-2008
Next Generation Sequencing (NGS) panels are increasingly used in advanced patients with cancer to guide therapy. There is, however, controversy about when should these be used, and their impact on the clinical course.In an observational study of 139 having NGS test [from January 1st, 2017 December 30th, 2020, two hospitals (Hospital Universitario de La Princesa Hospital Quironsalud Madrid) from Spain], we evaluated whether course (progression-free survival, PFS) was influenced by drug-based...
Transcription of microRNAs (miRNAs) is thought to be regulated similarly that protein-coding genes. However, how miRNAs are during the cell division cycle not well understood. We have analyzed transcription profiles in response mitogenic stimulation primary fibroblasts. About 33% expressed these cells induced upon exit from quiescence. Many specifically by E2F1 or E2F3 G(1)/S transition and repressed E2F1/3-knockout cells. At least four miRNA clusters, let-7a-d, let-7i, mir-15b-16-2,...
Upregulation of fatty acid synthase (FASN) is a common event in cancer, although its mechanistic and potential therapeutic roles are not completely understood. In this study, we establish key role FASN during transformation. required for eliciting the anaplerotic shift Krebs cycle observed cancer cells. However, main to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing power necessary quench reactive oxygen species (ROS) originated...
Abstract Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, we use high-throughput phosphoproteomics to build a functional TNBC taxonomy. A cluster of 159 phosphosites is upregulated in relapsed cases training set ( n = 34 patients), with 11 hyperactive kinases accounting for this phosphoprofile. mass-spectrometry-to-immunohistochemistry translation step, assessing 2 independent validation sets, reveals 6 preserved value. The split the into two patterns: one...
Abstract Background FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether overexpression and amplification are correlated, what is their distribution among luminal A or B HRPBC, if there a potential different prognostic role for currently unknown features. The of inhibitors HRPBC also unclear. Methods (FISH) (RNAscope) were investigated N = 251 patients cohort the METABRIC cohort; effects on survival...
Abstract Purpose: Tumor progression has been linked to stiffening of the extracellular matrix caused by fibrosis. Cancer cells can be mechanically conditioned stiff matrix, exhibiting a 1,004-gene signature [mechanical conditioning (MeCo) score]. Nintedanib demonstrated antifibrotic activity in idiopathic pulmonary This study explores nintedanib’s effect on breast cancer outcomes. Experimental Design: We present long-term follow-up and analysis neoadjuvant randomized phase II trial early...
Inappropriate activation of the GLI/hedgehog (GLI/Hh) signalling occurs in several human cancers, including haematological neoplasms. However, little is known about its relevance precursor T-cell lymphoblastic lymphomas (T-LBL) development. Moreover, mechanisms whereby GLI/Hh activated malignancies are not fully clear. Here, we show that gene Smoothened ( SMO ), only non-redundant this pathway, up-regulated mouse and T-LBL. Interestingly, down-regulation micro-RNAs mmu-miR-30a mmu-miR-141 as...
Abstract Precision oncology research is challenging outside the contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics a powerful approach to reveal patient subsets interest characterized by activity few kinases where underlying genomics complex. Here, we conduct phosphoproteomic screening samples from HER2-negative female breast cancer receiving neoadjuvant paclitaxel ( N = 130), aiming find candidate biomarkers sensitivity. Filtering 11...
AbstractCdc14 is a dual-specific phosphatase with relevant functions during mitotic exit in yeast. The relevance of vertebrate Cdc14 phosphatases not well understood due to the presence two paralogs, Cdc14A and Cdc14B, their dispensability for cell cycle progression. Here, we report that overexpression mammalian but Cdc14A, leads dramatic changes morphology malignant transformation normal murine fibroblasts. Cdc14B disrupts cytoskeletal F-actin organization loss actin stress fibers vinculin...
Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential cancer initiation playing critical role acquiring three-dimensional (3D) growth properties during transformation. In vivo inhibition of FASN before oncogenic activation prevents tumor development and invasive suggesting could be potential target prevention.
The effectiveness of a structured psychosocial intervention for women with breast cancer was studied in relation to control group. study conducted hospital setting Spain, and the aim programme foster higher quality life more positive mental adjustment cancer. Three measures were used: baseline, post-treatment 6-month follow-up both groups. dependent variables examined adjustment. independent variable programme. Subjects 188 who had been operated satisfied series medical criteria, no history...