A5074858166- Immune cells in cancer
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Immune responses and vaccinations
- Viral Infections and Outbreaks Research
- RNA modifications and cancer
- Kruppel-like factors research
- Restless Legs Syndrome Research
University of Chicago
2023-2024
Vascular diseases, including acute respiratory distress syndrome (ARDS) and atherosclerosis, are leading causes of global morbidity mortality, underscoring the critical need for innovative therapies. While human genetics has uncovered specific molecular mechanisms in endothelial cells that drive chronic vascular inflammation central to these conditions, effective vivo strategies spatiotemporally target disease-causing pathways using therapeutic mRNAs remain limited. Here, we present a...
ABSTRACT Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions systemic responses are poorly understood. Here, we leveraged a highly compartmentalized model of skin and identified surprising type I interferon (IFN)- mediated activation hematopoietic stem/progenitor cells (HSPCs) that results in profound changes to host responses. Post-inflamed mice were protected from atherosclerosis had worse outcomes...
Abstract Obesity increases the risk of several comorbidities, such as infertility. While weight loss is highly recommended, maintaining a normal typically unsuccessful, leading to regain (WR), which exacerbates inflammation and worsens compared stable obesity, with reasons unknown. Hence, understanding deleterious effects WR holds great potential for decreasing burden metabolic diseases well Here, we hypothesized that has an adverse effect on female fertility obesity. Females were fed...
Abstract Inflammation is a hallmark of obesity and associated with many complications, myeloid cells being major culprits. Weight loss improves obesity-related comorbidities, however, subsequent weight regain, known as cycling (WC), has been linked to worsening diseases. Therefore, it critical understand how WC impacts inflammation. We hypothesize that mice undergoing will have greater cell production heightened inflammatory capacity. To test this hypothesis, we characterized immune...