A5085792164- Geology and Paleoclimatology Research
- Geomagnetism and Paleomagnetism Studies
- Paleontology and Stratigraphy of Fossils
- Archaeology and ancient environmental studies
- Fungal and yeast genetics research
- Mycotoxins in Agriculture and Food
- Fungal Biology and Applications
- Isotope Analysis in Ecology
- Geological formations and processes
- Plant Pathogens and Fungal Diseases
- Diverse Topics in Contemporary Research
- Food Quality and Safety Studies
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Forensic Anthropology and Bioarchaeology Studies
- Thermal Regulation in Medicine
- Cervical Cancer and HPV Research
- Atomic and Subatomic Physics Research
- Streptococcal Infections and Treatments
- Urban Green Space and Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
- Sperm and Testicular Function
- Nutrition, Health and Food Behavior
National Institute of Biological Resources
2024
Peking University
2021-2023
Agency for Defense Development
2022
Seoul National University
2009-2022
Sungkyunkwan University
2022
Korea Institute of Ocean Science and Technology
2014-2021
Ewha Womans University
2017-2021
National Institute of Agricultural Science and Technology
2021
Einstein Medical Center Philadelphia
2021
Celltrion (South Korea)
2017-2021
The tumor-tropic properties of neural stem cells (NSCs) led to the development a novel strategy for delivering therapeutic genes tumors in brain. To apply this treatment brain metastases, we made human NSC line expressing cytosine deaminase (F3.CD), which converts 5-fluorocytosine (5-FC) into 5-fluorouracil, an anticancer agent. In vitro, F3.CD significantly inhibited growth tumor cell lines presence prodrug 5-FC. vivo, MDA-MB-435 breast cancer were implanted immune-deficient mouse...
Tetrandrine (TET), a bis-benzylisoquinoline alkaloid from the root of Stephania tetrandra, is known to have anti-tumor activity in various malignant neoplasms. However, precise mechanism by which TET inhibits tumor cell growth remains be elucidated. The present studies were performed characterize potential effects on phosphoinositide 3-kinase/Akt and extracellular signal-regulated kinase (ERK) pathways since these signaling are responsible for survival. suppressed proliferation induced...
Fusarium graminearum is a prominent plant pathogenic fungus causing head blight in major cereal crops worldwide. To understand the molecular mechanisms underlying fungal development and virulence, large collections of F. mutants have been constructed. Cytochrome P450 monooxygenases (P450s) are widely distributed organisms involved diverse array molecular/metabolic processes; however, no systematic functional analysis P450s has attempted filamentous fungi. In this study, we constructed...
The testis-derived male germ-line stem (GS) cell, the in vitro counterpart of spermatogonial cell (SSC), can initiate donor-derived spermatogenesis recipient testes and therefore, has been viewed as a future therapeutic modality for treatment infertility azoospermic patients cancer who are expecting chemotherapy. Upon extended culture, GS cells also generate second type called multipotent adult (maGS) which, upon testicular transplantation, produces teratoma instead initiating...
Abstract The Ari vent field (AVF) is an ultramafic-hosted seafloor massive sulfide (SMS) deposit in the middle part of Central Indian Ridge. In this paper, we describe detailed mineralogy and geochemistry hydrothermal samples from AVF, which can be classified into Fe–Cu- Cu-rich types based on major minerals. Sulfide mineralisation former type comprises: (1) stage I, early deposition magnetite, pyrrhotite, isocubanite, chalcopyrite, subhedral–euhedral pyrite under high-temperature fluid...
Summary Reactive oxygen species (ROS) are associated with various developmental processes and host–pathogen interactions in pathogenic fungi. Peroxidases a group of ROS‐detoxifying enzymes that involved the oxidative stress response variety physiological processes. In this study, we performed genome‐wide functional characterization putative peroxidase genes Fusarium graminearum , head blight pathogen cereal crops. We identified 31 generated deletion mutants for these genes. Twenty‐six showed...
Background Testis-derived male germ-line stem (GS) cells, the in vitro counterpart of spermatogonial cells (SSC), can acquire multipotency under appropriate culture conditions to become multipotent adult (maGS) which upon testicular transplantation, produce teratoma instead initiating spermatogenesis. Consequently, a molecular marker that distinguish GS from maGS would be potential value both clinical and experimental research settings. Methods Findings Using mouse as model system, here we...
The density (BSG) of bone increases, at the osteon scale, during lifetime aging within bone. In addition, post-mortem diagenetic change due to microbial attack produces denser bioapatite. Thus, fractionation finely powdered on basis should not only enable younger and older populations osteons be separated but also make it possible separate out a less diagenetically altered component. We show that method can used as tool investigate isotopic history an individual's lifetime, both in recent...
Genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system has greatly facilitated genetic analysis of fungal pathogens. The head blight fungus, Fusarium graminearum , causes destructive losses economically important cereal crops. recent development CRISPR-Cas9 for use with F . enabled more efficient genome editing. In this study, we described a CRISPR-Cas9-based genome-editing tool direct delivery preassembled Cas9...
인골에서 추출된 콜라겐의 탄소와 질소 안정동위원소 정보는 당시 사람들의 식생활과 영양 상태, 생계 경제를 복원하는데 구체적인 가능성을 제시한다. 지금까지 우리나라의 신석기시대 유적에서는 인골이 많이 발견되지 않아 직접적인 식생활 양상 추적이 어려웠는데, 부산 가덕도 장항유적에서 출토된 인골 48개체의 확인은 매우 주목할 만한 성과이다. 본 연구에서는 분석을 수행하였으며, 평균값은 각각 다음과 같다(<TEX>${\delta}^{13}$</TEX>C=<TEX>$-14.5{\pm}1.3$</TEX>‰, <TEX>${\delta}^{15}$</TEX>N=<TEX>$-17.4{\pm}1.7$</TEX>‰, n=10). 뼈의 조직 분석 결과 보존 상태는 안좋은 HI (조직학 지수) 0을 나타냈으나, 뼈 경우 질 평가지수에 합격한 값만을 사용하여 생존 시 식생활을 반영한다는 것을 알 수 있었다. 당시의 고고학적인 정황을 고려할 때 장항 유적 피장자들은 해양성 식료를 주로 섭취하였고, 육상...
In this paper, we describe 72-year-old female patient without evidence of malignant disease presented with significantly elevated serum carbohydrate antigen (CA) 19-9 levels by respiratory infections. She was diagnosed infections due to Mycobacterium avium complex and Pseudomonas aeruginosa. The CA remarkably increased (1,453-5,300 U/mL; reference range, <37 U/mL) infection abruptly decreased (357-534 whenever controlled specific treatments. This case suggests that may be used as a...
The adverse effects of the phosphodiesterase-4 inhibitor roflumilast, appear to be more frequent in clinical practice than what was observed chronic obstructive pulmonary disease (COPD) trials. Thus, we designed this study determine whether could reduced by starting roflumilast at half dose, and then increasing a few weeks later 500 µg daily.We retrospectively investigated 85 patients with COPD who had taken either or dose 250 increased µg. We analyzed all events assessed differences between...
Current post-exposure prophylaxis for rabies virus infection has several limitations in terms of supply, cost, safety, and efficacy. Attempts to replace human or equine immune globulins (HRIG ERIG) have been made by companies institutes. We developed potent monoclonal antibodies neutralize a broad spectrum viruses screening hybridomas received from the U.S. Centers Disease Control Prevention (CDC). Two kinds chimeric (chimeric #7 #17) were constructed cloning variable regions selected...
The Ccr4-Not complex is evolutionarily conserved and important for multiple cellular functions in eukaryotic cells. In this study, the biological roles of FgNot3 subunit were investigated plant pathogenic fungus Fusarium graminearum. Deletion FgNOT3 resulted retarded vegetative growth, spore germination, swollen hyphae, hyper-branching. ΔFgnot3 mutants also showed impaired sexual asexual sporulation, decreased virulence, reduced expression genes related to conidiogenesis. Fgnot3 deletion...