A5100677677- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Identification and Quantification in Food
- Diatoms and Algae Research
- Hedgehog Signaling Pathway Studies
- Geology and Paleoclimatology Research
- Ocean Acidification Effects and Responses
- Marine and coastal ecosystems
- Porphyrin Metabolism and Disorders
- Folate and B Vitamins Research
- Liver physiology and pathology
- TGF-β signaling in diseases
- Cell death mechanisms and regulation
- Biofuel production and bioconversion
- Renal and related cancers
- Biopolymer Synthesis and Applications
- Enzyme Production and Characterization
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Genetic and Kidney Cyst Diseases
- Microbial Metabolic Engineering and Bioproduction
- Pediatric Hepatobiliary Diseases and Treatments
- RNA Research and Splicing
- Karst Systems and Hydrogeology
- ATP Synthase and ATPases Research
Children's Hospital of Philadelphia
2024
Gansu Provincial Hospital
2023-2024
Lanzhou University Second Hospital
2023
Lanzhou University
2023
Chinese Academy of Sciences
2010-2022
Institute of Earth Environment
2020
Anhui Medical University
2020
Wuhan Institute of Virology
2020
Center for Excellence in Brain Science and Intelligence Technology
2020
Ministry of Education of the People's Republic of China
2020
The only known source of vitamin B12 (adenosylcobalamin) is from bacteria and archaea. Here, using genetic metabolic engineering, we generate an Escherichia coli strain that produces via engineered de novo aerobic biosynthetic pathway. In vitro and/or in vivo analysis genes involved adenosylcobinamide phosphate biosynthesis Rhodobacter capsulatus suggest the steps co(II)byrinic acid a,c-diamide to adocobalamin are same both anaerobic pathways. Finally, increase yield a recombinant E. by more...
Abstract Glioblastoma (GBM) is the most aggressive brain tumor and characterized by a poor prognosis high recurrence mortality rates. Biochanin A (BCA) exhibits promising clinical anti-tumor effects. In this study, we aimed to explore pharmacological mechanisms which BCA acts against GBM. Network pharmacology was employed identify overlapping target genes between Differentially expressed from Gene Expression Profiling Interactive Analysis 2 (GEPIA2) database were visualized using VolcaNose....
Abstract Purpose Glioblastoma (GBM) is the most malignant type of brain tumor, characterized by a poor prognosis and high recurrence mortality rates. Biochanin A (BCA) has demonstrated promising clinical antitumor effects. This study aimed to explore pharmacological mechanisms which BCA acts against GBM. Methods Network pharmacology was employed identify overlapping target genes between Differentially expressed were extracted from Gene Expression Profiling Interactive Analysis 2 database...
Monthly in situ monitoring of cave air CO2 and drip water chemistry were carried out Shenqi Cave, Sichuan, southwest China, during a hydrological year from April 2016 to December 2016. Results indicate that the temperature (~11.7°C) relative humidity (~100%) stable whole year. The CH4 concentrations changed ~2000ppb outside ~500ppb inside cave. average varied ~550ppm winter ~1200ppm summer, with their δ13C values ~ –15‰ –21‰, indicating influences seasonal biologic activities ventilation...
Microbial enrichment is an effective method to obtain highly abundant methanogenic propionate-degrading microbial consortia (syntrophic consortia) in complex environments. Nevertheless, there were few studies about dynamic community change and syntrophic mechanisms over a long time bioreactor operation. In this study, the efficient enriched CSTR, effect of propionic acid loading (PAL) on structure functional pathways was investigated. By single injection mode (30mL injected into reactor once...