Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of interactions essential for optimizing mating satisfaction enhancing physiological conditions needed successful fertilization. So far, traditional research on has relied limited set behavioral parameters, which certain shortcomings. To address this, our study aimed to develop more detailed framework assessing temporal copulatory...

This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in context of sexual behavior and sucrose self-administration. The role CaMKIIa+ neurons bed nucleus stria terminalis (BNST) was explored using chemogenetic silencing -stimulation. Additionally, examined how these effects interacted with internal state animals. Through detailed behavioral analysis, it demonstrated BNST play a significant regulation both...

The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, characterized by its high palatability, particularly associated with the potential excessive consumption. While prior studies indicate that junk food intake can impact circuitry, precise mechanisms underlying these effects remain elusive. Furthermore, it unclear whether functionality of this neural similarly altered other natural rewards. In study, we...

The use of selective serotonin reuptake inhibitors (SSRI) during pregnancy has increased tremendously, but the consequences for offspring remain largely unclear. Several studies have described potential effects perinatal SSRI-exposure on neurobehavioral outcomes using simplified rodent test set-ups, however these set-ups only assess a small fraction behavior. For translational purposes it is important to take environmental influences into account which children are exposed in real life. By...

The medial amygdala (MeA) is a sexually dimorphic brain region that integrates sensory information and hormonal signaling, involved in the regulation of social behaviors. Lesion studies have shown role for MeA copulation, most prominently promotion ejaculation. sexual motivation, but also temporal patterning has not been extensively studied rats. Here, we investigated effect chemogenetic inhibition stimulation on incentive motivation copulation experienced male AAV5-CaMKIIa viral vectors...

Excessive consumption of highly palatable foods rich in sugar and fat, often referred to as "junk" or "fast" foods, plays a central role the development obesity. The characteristics these activate hedonic motivational mechanisms promote food-seeking behavior overeating, which is largely regulated by brain reward system. junk food can alter functioning this system, but exact changes are still unknown. This study investigated whether long-term consumption, form Cafeteria (CAF) diet, system...

Summary Background Little is known about symptom characteristics of treated achalasia patients and their effect on health‐related quality‐of‐life (HRQoL). Aims To examine clinical remission, achalasia‐associated symptoms HRQoL in patients. Methods The Eckardt score, RAND‐36 a disease‐specific questionnaire were sent to 171 Results 76.6% the returned questionnaire. 44.9% them not symptomatic remission. Prevalence frequent dysphagia (at least daily) chest pain weekly) was 46% 38%,...

The aim of this study was to validate a translated version an achalasia-specific quality-of-life questionnaire (achalasia-DSQoL) by examining its psychometric properties in Dutch cohort achalasia patients. achalasia-DSQoL administered 171 treated patients together with clinical symptom score and the RAND-36. Validation methods included factor analysis, known-group techniques, Cronbach's alpha Spearman rank correlation other questionnaires feasibility. About 72.5% completed questionnaires....

SSRIs are commonly used to treat pregnant women with depression. However, can cross the placenta and affect development of fetus. The effects perinatal SSRI exposure, especially on social behavior, still incompletely documented. This study first aims investigate whether rats show prosocial behavior in form consolation behavior. Secondly, it exposure affects this At last, we changed after had been exposed an additional white-noise stressor. Rat dams received 10 mg/kg/d fluoxetine (FLX) or...

Objective. In patients with achalasia, little is known about symptoms of the gastrointestinal tract other than esophagus. The purpose this study was to determine prevalence two functional disorders, dyspepsia (FD) and irritable bowel syndrome (IBS), in a group treated achalasia assess additional impact these disorders on health-related quality life (HRQoL). Material methods. Questionnaires assessing Rome II criteria for FD IBS together Eckardt clinical symptom score RAND-36 were sent 171...

Serotonin plays an important role in adult female sexual behavior, however little is known about the influence of serotonin during early development on functioning adulthood. During development, acts as neurotrophic factor, while it functions a modulatory neurotransmitter The occurrence release, could thus have different effects behavioral outcomes, depending developmental period which released. Because involved HPG axis required for puberty establishment, also alter expression patterns...

Abstract This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in context of sexual behavior and sucrose self-administration. The role CaMKIIa+ neurons bed nucleus stria terminalis (BNST) was explored using chemogenetic silencing -stimulation. Additionally, examined how these effects interacted with internal state animals. Through detailed behavioral analysis, it demonstrated BNST play a significant regulation...

Abstract Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of interactions essential for optimizing mating satisfaction enhancing physiological conditions needed successful fertilization. So far, traditional research on has relied limited set behavioral parameters, which certain shortcomings. To address this, our study aimed to develop more detailed framework assessing temporal...

Summary The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, known its high palatability, particularly associated with the potential excessive consumption. While previous studies have shown that junk food intake can impact circuitry, precise mechanisms remain unclear. Additionally, it unknown whether functionality of this similarly altered other natural rewards. In study, we used fiber photometry...

Abstract The medial amygdala (MeA) is a sexually dimorphic brain region that integrates sensory information and hormonal signaling, involved in the regulation of social behaviors. Lesion studies have shown role for MeA copulation, most prominently promotion ejaculation. sexual motivation, but also temporal patterning has not been extensively studied rats. Here, we investigated effect chemogenetic inhibition stimulation on incentive motivation copulation experienced male AAV5-CaMKIIa viral...

Abstract SSRIs are commonly used to treat pregnant women with depression. However, can cross the placenta and affect development of fetus. The effects perinatal SSRI exposure, especially on social behavior, still incompletely documented. This study first aims investigate whether rats show prosocial behavior in form consolation behavior. Secondly, it exposure affects this At last, we changed after had been exposed an additional white-noise stressor. Rat dams received 10 mg/kg/d fluoxetine...

Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various affective disorders during pregnancy. SSRIs cross the placenta and affect serotonergic neurotransmission in fetus, but neurobehavioral consequences offspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations both social non-social aspects of behavior. However, this mainly focused on behavior within simplified environments. The current study...

Abstract Excessive consumption of highly palatable foods rich in sugar and fat, often referred to as “junk” or “fast” foods, plays a central role the development obesity. The characteristics these activate hedonic motivational mechanisms promote food-seeking behavior overeating, which is largely regulated by brain reward system. junk food can alter functioning this system, but exact changes are still unknown. This study investigated whether long-term consumption, form Cafeteria (CAF) diet,...

Abstract Serotonin plays an important role in adult female sexual behavior, however little is known about the influence of serotonin during early development on functioning adulthood. During development, acts as neurotrophic factor, while it functions a modulatory neurotransmitter The occurrence release, could thus have different effects behavioral outcomes, depending developmental period which released. Because involved HPG axis required for puberty establishment, also alter expression...

Abstract Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various affective disorders during pregnancy. SSRIs cross the placenta and affect serotonergic neurotransmission in fetus, but neurobehavioral consequences offspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations both social non-social aspects of behavior. However, this mainly focused on behavior within simplified environments. The current...