A5052695263- RNA regulation and disease
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Oral Health Pathology and Treatment
- Autoimmune and Inflammatory Disorders
- Fuel Cells and Related Materials
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Autoimmune Bullous Skin Diseases
- Hidradenitis Suppurativa and Treatments
University of Mount Union
2018-2024
Kent State University
2013-2023
Abstract Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on (ADARs) catalyze the deamination of adenosine to inosine. ADAR plays an important role in regulating brain function and immune activation, dynamically regulated during development. Additionally, ADAR1 p150 isoform induced by interferons viral infection antiviral response. However, question how virus-induced expression affects host remains largely unanswered. This...
Abstract Background As the number of RNA-seq datasets that become available to explore transcriptome diversity increases, so does need for easy-to-use comprehensive computational workflows. Many tools facilitate analyses one two major mechanisms diversity, namely, differential expression isoforms due alternative splicing, while second mechanism—RNA editing post-transcriptional changes individual nucleotides—remains under-appreciated. Both these play an essential role in physiological and...
Parkinson's Disease (PD) is the second most common neurodegenerative disease behind Alzheimer's Disease, currently affecting more than 10 million people worldwide and 1.5 times males females. The progression of PD results in loss function due to neurodegeneration neuroinflammation. etiology multifactorial, including both genetic environmental origins. Here we explored changes RNA editing, specifically editing through actions Adenosine Deaminases Acting on (ADARs), PD. Analysis ADAR skeletal...
Abstract Parkinson’s Disease (PD) is a multifactorial disease with heterogenous phenotypes that vary across individuals, as well by age and sex. Therefore, it likely multiple interacting factors, such environmental influences aging, genetic including dynamic RNA (ADAR, Adenosine Deaminases Acting on RNA) editing, may play role in PD pathology. In this analysis of 317 transcriptomes healthy controls, prodromal patients aged 65 years or older, from Project Markers Initiative dataset, we...
Abstract Background As the number of RNA-seq datasets that become available to explore transcriptome diversity increases, so does need for easy-to-use comprehensive computational workflows. Many tools facilitate analyses one two major mechanisms diversity, namely, differential expression isoforms due alternative splicing, while second mechanism - RNA editing post-transcriptional changes individual nucleotides – remains under-appreciated. Both these play an essential role in physiological and...
Abstract Parkinson’s Disease (PD) is the second most common neurodegenerative disease behind Alzheimer’s Disease, currently affecting more than 10 million people worldwide and 1.5 times males females. The progression of PD results in loss function due to neurodegeneration neuroinflammation. etiology multifactorial, including both genetic environmental origins. Here we explored changes RNA editing, specifically editing through actions Adenosine Deaminases Acting on (ADARs), PD. Analysis ADAR...
Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on (ADARs) catalyze the deamination of adenosine to inosine. ADAR plays an important role in regulating brain function and immune activation, dynamically regulated during development. Additionally, ADAR1 p150 isoform induced by interferons viral infection antiviral response. However, question how virus-induced expression affects host remains largely unanswered. This...