Shahrokh Paktinat

ORCID: 0000-0003-1660-6878
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About
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Research Areas
  • Reproductive System and Pregnancy
  • Endometriosis Research and Treatment
  • Reproductive Biology and Fertility
  • Reproductive Health and Technologies
  • Sperm and Testicular Function
  • Birth, Development, and Health
  • Circadian rhythm and melatonin
  • Reproductive tract infections research
  • COVID-19 Impact on Reproduction
  • Ovarian function and disorders
  • Toxoplasma gondii Research Studies
  • Uterine Myomas and Treatments
  • Ectopic Pregnancy Diagnosis and Management
  • Extracellular vesicles in disease
  • Testicular diseases and treatments
  • Sex work and related issues
  • Heme Oxygenase-1 and Carbon Monoxide
  • Urinary Tract Infections Management
  • Connexins and lens biology
  • Bee Products Chemical Analysis
  • Pregnancy and Medication Impact
  • Laser Applications in Dentistry and Medicine
  • Cervical Cancer and HPV Research
  • Pregnancy-related medical research
  • Genital Health and Disease

Shahid Beheshti University of Medical Sciences
2017-2025

University of Washington
2023-2025

Iran University of Medical Sciences
2021

University of Tabriz
2013

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus causing disease 2019 (COVID-19). Because COVID-19 a multisystem infection, there are some concerns regarding its possible effects on male fertility. This study aimed to investigate of semen oxidative status and parameters 14 120 days after diagnosis in patients presenting with moderate infection (defined as symptoms, or without fever, Spo2 <93% >90% lung involvement <50%). Semen samples were obtained from 20...

10.1071/rd21153 article EN cc-by Reproduction Fertility and Development 2021-07-29

Background The current testing approach to diagnose Chlamydia trachomatis (CT) infection relies on nucleic acid amplification tests (NAATs). These are highly sensitive, but do not distinguish between active and residual bacterial which may remain after resolution of infection, or via cross-contamination. Better methods assess the viability CT detected in clinical samples would be useful determining relevance detection a variety settings. goal this study was test PCR (vPCR) as method viable...

10.3389/frph.2023.1199740 article EN cc-by Frontiers in Reproductive Health 2023-08-04

Coronavirus disease 2019 (COVID-19) was identified in China late December and led to a pandemic that resulted millions of confirmed cases deaths. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), uses distinct receptors co-receptors enter host cells. Vimentin has emerged as potential co-receptor for SARS-CoV-2 due the high level vimentin expression testis tissue. present study investigated link between SARS-CoV-2-induced orchitis. In this case-control study,...

10.18502/ijrm.v22i11.17822 article EN cc-by-nc International Journal of Reproductive BioMedicine (IJRM) 2025-01-01

The regulation of immune responses to promote tolerance the fetus is critical for successful pregnancy. An understudied aspect this process initiation pre-conception via exposure semen. Our study aimed understand how semen impacts recipient dendritic cells (DCs) and their subsequent role in shaping CD4 T cell differentiation. Monocyte-derived DCs (MoDCs) were exposed extracellular vesicles (SEV) or vesicle-depleted plasma (VDSP). Phenotypic functional markers analyzed using flow cytometry....

10.3389/fimmu.2025.1564002 article EN cc-by Frontiers in Immunology 2025-05-12

The imbalance of Th17/Treg cells has been recently suggested as a new risk factors for recurrent implantation failure (RIF). Furthermore are involved in immune regulation peripheral blood and endometrial tissue patients with RIF. In this research, we investigated the effects Hydroxychloroquine (HCQ) on level function Th17 Treg women It may be possible to improve pregnancy outcomes by modulating high cytokine levels.Women RIF received oral HCQ (n = 60) day 4 menstrual cycle continued until 20...

10.1080/08923973.2020.1835951 article EN Immunopharmacology and Immunotoxicology 2020-10-21

ABSTRACT Non-neutralizing functions of antibodies, including phagocytosis, may play a role in Chlamydia trachomatis (CT) infection, but these have not been studied and assays are lacking. We utilized flow-cytometry-based assay to determine whether serum samples from well-characterized cohort CT-infected naïve control individuals enhanced phagocytosis via Fc-receptor-expressing THP-1 cells, this activity correlated with antibody titers. Fc-receptor-mediated was detected only CT+ donors....

10.1128/iai.00503-23 article EN Infection and Immunity 2024-03-07

Endometriosis, a chronic inflammatory disease, is identified by the presence of endometrial tissue outside uterus. The prevalence this disease among reproductive-age women almost 10-15%. High levels IL-6 and IL-8 have been found in peritoneal fluid (PF) with endometriosis are involved its pathogenesis. Isolated stromal cells from 12 ectopic eutopic biopsies ovarian endometrioma also nonendometriotic controls were treated 1.1 µM pyrvinium pamoate, Wnt/β-catenin signaling pathway inhibitor,...

10.1177/0960327120964543 article EN Human & Experimental Toxicology 2020-10-06

Busulfan is an anticancer drug, which causes the apoptosis germ cells and azoospermia in humans animals. Abnormal morphology of spermatozoa related to male infertility. The sperm evaluation size, shape appearance characteristics should be assessed by carefully observing a stained sample under microscope. Evaluation has been considered as one most important factors for successful fertilization determining quality. mice were assigned tow experimental groups: control busulfan. Each group...

10.5115/acb.2017.50.4.301 article EN Anatomy & Cell Biology 2017-01-01

Endometriosis is characterized by the presence of functional endometrial tissue in other pelvic organs. This gynecologic problem occurs 35–50% women with pain and infertility. Endometriotic cells share some characteristics such as proliferation, migration, invasion tumor cells. Pyrvinium pamoate, an anthelmintic drug approved Food Drug Administration, could inhibit Wnt/β-catenin signaling pathway its anticancer effects were examined several researchers. In this study, 12 ectopic eutopic...

10.1177/0960327119896612 article EN Human & Experimental Toxicology 2019-12-27

Antioxidants are commonly used for maturation, fertilization and early development of embryos. Melatonin as an antioxidant have been recently proven to be useful the assisted reproductive technology. In present study, we evaluated roles melatonin in vitro fertilization, also gene expression high mobility group box-1 (HMGB1) blastocysts. The immature oocytes BDF1 mice were transferred media containing different doses (10-6, 10-9, 10-12 M). blastocysts that developed under from each stained...

10.1590/s2175-97902020000418882 article EN Brazilian Journal of Pharmaceutical Sciences 2021-01-01

Advances in embryo culture conditions and the development of vitrification as a revolutionary cryopreservation method have allowed for routine use blastocyst transfer assisted reproduction technology (ART) cycles. Several vitrification/warming media devices been introduced commercial so far. The aim this retrospective study was to compare post-warming survival rates clinical outcomes human blastocysts vitrified/warmed by two different methods (CryoTouch Cryotop) during ART cycles.This...

10.5935/1518-0557.20210116 article EN JBRA 2021-01-01

Abstract Background Vitrification has become the method of choice for cryopreservation human embryos and gametes. There are multiple commercial media, containing different combinations concentrations cryoprotectants, available vitrification warming procedures. The aim this retrospective study was to compare post-warming survival rate clinical outcomes cleavage stage vitrified/warmed using two methods (CryoTouch Cryotop) during intracytoplasmic sperm injection/frozen embryo transfer...

10.1186/s43043-021-00068-1 article EN cc-by Middle East Fertility Society Journal 2021-08-13
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