A5037057759- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Chemical Safety and Risk Management
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Occupational Health and Safety Research
- Analytical chemistry methods development
- Health Systems, Economic Evaluations, Quality of Life
- Protein Degradation and Inhibitors
- Occupational and environmental lung diseases
- Pesticide Exposure and Toxicity
- Histone Deacetylase Inhibitors Research
- Pesticide and Herbicide Environmental Studies
- Body Composition Measurement Techniques
- Traffic and Road Safety
- Contact Dermatitis and Allergies
- Heavy Metal Exposure and Toxicity
- Plant Pathogens and Resistance
- Peptidase Inhibition and Analysis
- Potato Plant Research
- Plant Micronutrient Interactions and Effects
- Pesticide Residue Analysis and Safety
University of Cincinnati
2018-2020
University of Cincinnati Medical Center
2015-2017
Royal Marsden NHS Foundation Trust
2013
Institute of Cancer Research
2013
National Center for Environmental Assessment (EPA)
2007-2013
Impact Assessment
2006-2012
Abstract Purpose: This first-in-human dose-escalating trial investigated the safety, tolerability, maximum tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, and pharmacodynamics of novel histone deacetylase (HDAC) inhibitor resminostat in patients with advanced solid tumors. Experimental Design: Resminostat was administered orally once-daily on days 1 to 5 every 14 at levels between 100 800 mg. Safety, including acetylation HDAC enzyme activity, antitumor efficacy were...
1,4-Dioxane is found in consumer products and used as a solvent manufacturing. Studies rodents show liver tumors to be consistently reported after chronic oral exposure. However, there were differences the reporting of non-neoplastic lesions livers rats mice. In order clarify these differences, reread mouse slides from 1978 NCI bioassay on 1,4-dioxane drinking water was conducted. This clearly identified dose-related changes liver; specifically, increase hypertrophic response hepatocytes,...
Several reports exist on the scientific underpinnings of uncertainty factors (e.g., Dourson and Stara 1983; McColl 1990; Kroes et al. 1993; Calabrese Baldwin 1995; 1996; Kalberla...
Asthma is a complex syndrome with significant consequences for those affected. The number of individuals affected growing, although the reasons increase are uncertain. Ensuring effective management potential exposures follows from substantial evidence that exposure to some chemicals can likelihood asthma responses. We have developed safety assessment approach tailored screening risks residential consumer product ingredients as proactive risk tool. Several key features proposed advance...