A5027497883- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Mast cells and histamine
- Sympathectomy and Hyperhidrosis Treatments
- Diabetes Treatment and Management
- Dermatological and COVID-19 studies
- Eosinophilic Disorders and Syndromes
- Celiac Disease Research and Management
- Cutaneous lymphoproliferative disorders research
- Chemotherapy-related skin toxicity
- Medication Adherence and Compliance
- Eosinophilic Esophagitis
- Respiratory and Cough-Related Research
- Pharmacovigilance and Adverse Drug Reactions
- Plant Surface Properties and Treatments
- Polyomavirus and related diseases
- Beetle Biology and Toxicology Studies
- Melanoma and MAPK Pathways
- Radiopharmaceutical Chemistry and Applications
Carol Davila University of Medicine and Pharmacy
2019-2025
College of Medical Sciences
2025
Mercy Medical Center
2009
The Health Economics of Allergic Diseases (HEAD) registry is a European-based developed by the European Academy Allergy and Clinical Immunology in collaboration with national allergy societies to facilitate standardised allergic disease management. Using an observational design, this first registry-based study describes care patterns for diseases their impact on healthcare system (diagnostic management costs), society (missed work/school days disability pension/support) patients...
Abstract Warfarin-induced skin necrosis (WSN) is a rare but serious complication of anticoagulation therapy. This case report describes 34-year-old male with mechanical heart valves on long-term warfarin therapy who developed WSN after self-medicating doubled dose following two-week interruption due to limited healthcare access in conflict-affected region. Concurrently, he was diagnosed dengue fever, further complicating management thrombocytopenia. Prompt discontinuation warfarin,...
Food-Induced Immediate Response of the Esophagus (FIRE) is a newly described syndrome observed in eosinophilic esophagitis (EoE) patients. It defined by an immediate hypersensitivity reaction esophagus that occurs when specific foods and beverages interface with esophageal mucosa. The available data regarding this topic scarce. Therefore, we aimed to review relevant publications order better characterize main aspects hypothesize about potential mechanisms underlying FIRE possible future...
Background: Irinotecan is a topoisomerase I inhibitor used for the treatment of various cancers, such as gastrointestinal, pancreatic, pulmonary, ovarian, and cervical cancers. Among chemotherapy agents, it represents rare trigger drug hypersensitivity reactions, with few cases being reported until today. Methods: We present case patient metastatic esophageal cancer history irinotecan-induced grade IV (WAO classification) anaphylaxis. An IgE-mediated reaction was confirmed in our case,...
Drotaverine is an antispasmodic drug used to treat gastrointestinal and genitourinary smooth muscle spasms. There are very few hypersensitivity reactions reported. Serum sickness-like disease immune-complex-mediated reaction that presents with some typical features include rash, fever articular impairment sometimes associated liver renal dysfunctions, beginning 1-2 weeks after exposure a culprit drug. Diagnosis clinical one, made usually on the basis of knowledge obtained by medical history...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are reported to be the leading cause of drug hypersensitivity reactions. The aim this study was characterize a cohort patients with NSAID and establish if there any differences between two groups adult patients, under 55 years old over old, identify safe alternative options.Patients who were referred single tertiary Allergy center from January 2019 December 2021 included. Clinical information obtained review medical records.A total 135 history...
e20722 Background: Outpatient chemotherapy/biotherapy in oncologist's offices are being utilized greater numbers, increasing the risks of acute allergic reactions. Methods: The clinical charts patients receieving prolonged infusion treatments (1–3 hours infusion) a community office setting were reviewed to determine rate(risk), management and outcome severe Results: From January 2007 December 2008, there 1453 patient infusions conducted. 653 800 2008. All premedicated with antiemetics, H2...
Dabrafenib and trametinib are two available molecules that have been approved for the treatment of metastatic melanoma with BRAF-V600E or V600K mutations. Their combined therapy has led to long-lasting survival benefits substantially improved outcomes. Until now, only a few cases severe hypersensitivity reactions dabrafenib vemurafenib reported, even fewer desensitization protocols these documented. We report case 71-year-old female patient harboring mutation undergoing targeted trametinib....
Food allergy and asthma coexist in many children, although it remains unclear whether or not food are simply associated to each other due the underlying predisposition atopic diseases they actually causally related. We present case of a seven years old boy with recurrent episodes anaphylaxis (4 one year). Each episode occurred after ingestion foods containing peanuts consisted generalized urticaria wheezing. 6 months last he developed persistent symptoms (shortness breath, cough wheezing)...
Fish allergy is one of the most common food allergies and has become an important concern worldwide. Prevalence variable (0-7%) influenced by regional dietary habits. Although fish known to be inducer IgE-mediated reactions, other forms clinical presentation, such as non-immediate reactions (predominantly induced enterocolitis syndrome, FPIES)“, are also described. The diagnosis established correlating anamnestic data with those obtained through in vivo/in vitro tests confirmed oral...
Chronic spontaneous urticaria (CSU) is the most common form of chronic urticaria, frequently evaluated in allergology and dermatology services, with an increasing incidence, evolution usually several years often incompletely controlled by treatment, strongly impacting patient's quality life. The current therapeutic algorithm recommended international guideline, although useful, not perfect, given fact that it based on a one-size-fits-all approach for all CSU patients: initially,...
Proton pump inhibitors (PPIs) are highly safe medicines, commonly used as first-line treatment for various digestive diseases. However, the use of PPIs expands, hypersensitivity reactions (HSRs), including both immediate and delayed reactions, have become more prevalent. The most frequent HSR observed in patients treated with is anaphylaxis. Skin tests (prick intradermal) followed by an oral challenge test suggested accurately diagnosing HSRs to PPIs, due their high specificity. It crucial...
Shellfish allergy is one of the most common food allergies, with an estimated prevalence 3% in general population. Crustaceans and mollusks are part this category, being capable immunologic hypersensitivity reactions (IgE-mediated, as well non-IgE-mediated), but also non-immunologic reactions, based on intoxication certain neurotoxins from contaminated seafood, which neurological gastrointestinal symptoms predominate. The clinical picture IgE-mediated can vary severity, mild such oral...
Non-steroidal anti-inflamatory drugs (NSAIDs) are frequently used for their analgesic, antipyretic, and anti-inflammatory activity in all age groups. Currently, NSAIDs the most common involved hypersensitivity reactions. Also, besides exercise alcohol, mentioned as augmenting factors food elicited anaphylaxis. Some of potentially NSAID-induced reactions have provocation test with culprit drug negative. It is well known that can sometimes amplify immediate patients food-dependent induced The...