A5075963780- Hepatitis B Virus Studies
- Hepatitis C virus research
- Axon Guidance and Neuronal Signaling
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Influenza Virus Research Studies
- interferon and immune responses
- RNA Research and Splicing
- Hepatitis Viruses Studies and Epidemiology
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- HIV Research and Treatment
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Kruppel-like factors research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- RNA regulation and disease
Université Claude Bernard Lyon 1
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Inserm
2016-2025
Centre International de Recherche en Infectiologie
2025
École Normale Supérieure de Lyon
2025
Centre Léon Bérard
2016-2022
Institut des Sciences Biologiques
2022
Centre de Recherche en Cancérologie de Lyon
2016-2022
University of Tübingen
2021
Research Article5 September 2016Open Access Source DataTransparent process ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors Geoffrey Richard Cancer Center of Lyon, INSERM U1052, France CNRS UMR 5286, Université de ISPB, Lyon 1, Centre Léon Bérard, Search for more papers by this author Stéphane Dalle Dermatology Unit, Hospices Civils CH Sud, Pierre Bénite Cedex, Marie-Ambre Monet Maud Ligier Amélie Boespflug Roxane M Pommier Arnaud la Fouchardière Department...
Background and Aims Therapeutic strategies against HBV focus, among others, on the activation of immune system to enable infected host eliminate HBV. Hypoxia‐inducible factor 1 alpha (HIF1α) stabilization has been associated with impaired responses. pathogenesis triggers chronic hepatitis‐related scaring, leading inter alia modulation liver oxygenation transient activation, both factors playing a role in HIF1α stabilization. Approach Results We addressed whether interferes immune‐mediated...
The liver, and more precisely hepatocytes, can be infected by several hepatotropic viruses, including HBV, HDV, HCV HEV, with chronic infection leading to end-stage liver diseases. Since no in vitro model allowing multi-infections the four viruses is reported, limited data are available on their interplay as well potential cross-reactivity of antivirals multi-infection cases. aim our study was set up such a model. HuH7.5-NTCP cells were cultured 2% DMSO (dimethyl sulfoxide) for 1 week allow...
Abstract Background and Aims Netrin‐1 displays protumoral properties, though the pathological contexts processes involved in its induction remain understudied. The liver is a major model of inflammation‐associated cancer development, leading to HCC. Approach Results A panel cell biology biochemistry approaches (reverse transcription quantitative polymerase chain reaction, reporter assays, run‐on, polysome fractionation, cross linking immunoprecipitation, filter binding assay, subcellular...
Immune-mediated induction of cytidine deaminase APOBEC3B (A3B) expression leads to HBV covalently closed circular DNA (cccDNA) decay. Here, we aimed decipher the signalling pathway(s) and regulatory mechanism(s) involved in A3B related control. Differentiated HepaRG cells (dHepaRG) knocked-down for NF-κB components, transfected with siRNA or micro RNAs (miRNA), primary human hepatocytes ± HBVΔX HBV-RFP, were treated lymphotoxin beta receptor (LTβR)-agonist (BS1). The biological outcomes...
Hepatitis B virus (HBV) remains a major health problem with 257 million people chronically infected. Current treatments can control the infection but does not allow its complete eradication leading to relapses upon withdrawn or resistance development. These are due persistence of covalently closed circular DNA (cccDNA), which is efficiently targeted by those treatments. Agonization lymphotoxin β receptor (LTβR) BS1 was shown induce APOBEC3B (A3B), induces damage into cccDNA, eventually leads...