We studied the effects of several different doses gamma radiation, ranging from 20,000 to 40,000 gray (2.0 4.0 megarad), with respect inactivation human immunodeficiency virus in fresh-frozen, whole bone-patellar ligament-bone grafts. Although International Atomic Energy Agency has recommended use 25,000 radiation for sterilization medical products, dose required frozen allografts not been established. Using one most sensitive and specific tests detection virus, polymerase-chain-reaction...

Abstract Seneca Valley virus (SVV), a new member of Picornaviridae , causes idiopathic vesicular symptoms in pregnant sows and acute death neonatal piglets, considerably damaging the swine industry. The viral protease 3C (3C pro ) cleaves host immune-related molecules to create favorable environment for replication. In this study, we found that mRNA decapping enzyme 1A (DCP1A) is novel antiviral effector against SVV infection targets 3D RNA-dependent RNA polymerase OPTN-mediated autophagic...

To study and explore the adoption value of magnetic resonance imaging (MRI) in diagnosis anterior cruciate ligament (ACL) injuries, a multimodal feature fusion model based on deep learning was proposed for MRI diagnosis. After related performance algorithm evaluated, it utilized knee joint injuries. Thirty patients with injuries who came to our hospital treatment were selected, all diagnosed (MRI group) arthroscopy (arthroscopy group). The results showed that learning-based sagittal plane...

ABSTRACT Seneca Valley virus (SVV) is a newly identified pathogen that poses notable threat to the global pig industry. SVV has evolved multiple strategies evade host antiviral innate immune responses. However, underlying molecular mechanisms have not yet been fully elucidated. Histone deacetylases (HDACs) shown function as factors. In this study, we examined evasion of immunity and found infection induced degradation cleavage HDAC4. Ectopic expression HDAC4 suppressed replication, whereas...

ABSTRACT Seneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry. DNA and RNA viruses manipulate host damage response (DDR) modulate cellular machinery facilitate their life cycles. However, interaction between DDR SVV infection remains unexplored. Here, we aimed comprehensively investigate repair signaling pathways during infection. We found triggers distinct pathways, including ataxia...

The aim of this study is to explore the clinical effect deep learning-based MRI-assisted arthroscopy in early treatment knee meniscus sports injury. Based on convolutional neural network algorithm, Adam algorithm was introduced optimize it, and magnetic resonance imaging (MRI) image super-resolution reconstruction model (SRCNN) established. Peak signal-to-noise ratio (PSNR) structural similarity (SSIM) were compared between SRCNN other algorithms. Sixty patients with injury joint studied....

The treatment of complex acetabular fractures remains a complicated clinical challenge. Our self-designed novel anatomical locking guide plate (NALGP) has previously shown promising potential in T-shaped (TAF), but direct comparison with conventional fixations is yet to be made. TAF model was established based on volunteer's computer tomography data and then fixed double column plates (DLP), posterior anterior screws (LPACS), our NALGP. Forces 200 N, 400 600 N were loaded the vertically...

aDepartment of Orthopedics, Shenzhen Children's Hospital, Shenzhen, Guangdong, China bMedical School Chinese PLA, Beijing, cClinical Science Institute, University Hospital Galway, Ireland (Our submission is a letter-to-the-editor) Sponsorships or competing interests that may be relevant to content are disclosed at the end this article. Published online ■ *Corresponding author. Address: Address for correspondence: Clinical Newcastle Road, H91 YR71, TEL: +353 091-495-0743 E-mail address:...

Tuberculous peritonitis (TP) can cause multiple infections of surrounding organs and tissues, leading to organ failure endangering life safety. In this research, the relationship between adenosine deaminase (ADA), NLRP3 inflammasome, TP its clinical significance will be deeply explored, so as provide new directions reliable reference opinions for future diagnosis treatment. Altogether, 59 patients (research group, RG) 52 non-TP (control CG) who were admitted our hospital from May 2014 June...

A receptor is a protein molecule that receives chemical signals from outside cell, which enables the cell to respond signal molecule. Receptors mediate numerous important physiologic effects upon binding extracellular agonists. However, sustained activation of may lead pathologic effects. Cells can regulate number and function receptors alter their sensitivity different molecules by feedback mechanism, such as change in conformation, uncoupling effector molecules, sequestration, etc. In this...

A deeper understanding of the anatomy intercondylar notch femur may help reduce technical errors during anatomic anterior cruciate ligament (ACL) reconstruction.To classify number ridges on lateral wall, identify factors influencing ridges, and define relationship between area denser bone wall ridge.Descriptive laboratory study.Included were 89 patients with computed tomography (CT) images knee joint. On full view femoral condyle, authors evaluated for presence a ridge. The height (notch...

Abstract Objectives The aim of this paper is to introduce a new assist strategy for direct device that can enhance the heart’s pumping efficiency and decrease chances myocardial injury in contrast conventional strategy. Methods We established finite element model biventricular heart, divided ventricles into several regions, applied pressure each region separately order identify primary secondary areas. Then combined tested these areas obtain optimal Results results indicate our method...

Two opinions in tracheobronchial resection and reconstruction regarding the management of airway anastomosis remain controversial: whether to wrap with surrounding tissue or leave without additional embedding. This study aims explore relationship between choice anastomotic wrapping complications surgery. Patients who underwent surgery January 2019 December 2021 were retrospectively analyzed. A total 95 patients enrolled, their age comorbidities quantified using age-adjusted Charlson...