A5101550902- Folate and B Vitamins Research
- GDF15 and Related Biomarkers
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Moyamoya disease diagnosis and treatment
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Arrest and Resuscitation
- Calcium signaling and nucleotide metabolism
- Peptidase Inhibition and Analysis
- Barrier Structure and Function Studies
- Antioxidant Activity and Oxidative Stress
- Eosinophilic Disorders and Syndromes
- Cardiovascular and Diving-Related Complications
- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Autophagy in Disease and Therapy
- Renin-Angiotensin System Studies
- Lipid metabolism and disorders
- Acute Myocardial Infarction Research
- Alzheimer's disease research and treatments
- Pregnancy and preeclampsia studies
Shaoxing People's Hospital
2009-2024
Zhejiang University
2012-2023
Shaoxing University
2009-2022
Wenzhou Medical University
2015
Doxorubicin (DOX) is a commonly used chemotherapy drug widely applied in various cancers such as breast cancer, leukemia, and sarcomas. However, its usage limited by cardiotoxicity. Additionally, the cardiac toxicity of DOX accumulates with dose duration, making it imperative to identify therapeutic targets for DOX-induced cardiomyopathy (DIC). It has been reported that miRNAs are involved progression DIC. Mir-34a-5p identified an early diagnostic marker While studies have shown involvement...
Our previous study found that Chinese yellow wine could inhibit the production of homocysteine (HCY) induced extracellular matrix metalloproteinase-2 (MMP-2) in cultured rat vascular smooth muscle cells. Little is known about relationship between and atherosclerosis or MMP-2 vivo. Thirty-two LDL Receptor knockout mice on a high-fat L-methionine diet developed plasma hyperhomocysteinemia atherosclerosis. They were randomly divided into group (n = 8), red ethanol control they sacrificed after...
Angiotensin II (Ang II) is reported to be involved in the development of various cardiovascular diseases by disrupting microvessel permeability, however, underlying mechanism remains elucidated. The present study aimed investigate which Ang disrupts microvascular permeability. Rat endothelial cells were subjected primary culture and identification. Cells passages 4‑7 then used for following experiments. divided into control, II, + valsartan groups, reverse transcription‑quantitative...
The high prevalence of patent foramen ovale (PFO) in cryptogenic stroke suggested a stroke-causing role for PFO. As risk factors recurrence such are not recognized, clinicians cannot sufficiently identify, treat, and follow-up high-risk patients. Therefore, this study aimed to establish prediction model PFO-related recurrence.This included 392 patients with training set 164 an independent validation set. In the set, identified using forward stepwise Cox regression were nomogram 1, those...
Abstract Background: The available evidence regarding the benefits of percutaneous coronary intervention (PCI) on patients receiving dialysis with artery disease (CAD) is limited and inconsistent. This study aimed to evaluate association between PCI clinical outcomes as compared medical therapy alone in undergoing CAD China. Methods: multicenter, retrospective was conducted 30 tertiary centers across 12 provinces China from January 2015 June 2021 include CAD. primary outcome major adverse...
To investigate the effect of rosuvastatin on homocysteine (Hcy) induced mousevascular smooth muscle cells(VSMCs) dedifferentiation and endoplasmic reticulum stress(ERS).VSMCs were co-cultured with Hcy different concentration (0.1, 1.0 10 μmol/L). Cytoskeleton remodeling, VSMCs phenotype markers (smooth actin-α, calponin osteopontin) ERS marker mRNAs (Herpud1, XBP1s GRP78) detected at predicted time. Tunicamycin was used to induce, respectively 4-phenylbutyrate(4-PBA) inhibition, in cellular...
Objective: To investigate the impact of homocysteine inducible endoplasmic reticulum(ER) protein with ubiquitin like domain 1 (Herpud1) in (Hcy) -induced phenotypic switching vascular smooth muscle cells (VSMCs). Methods: VSMCs were derived from thoracic aortic artery male Sprague Dawley rats and cultured (4-7 passage) treated various concentrations Hcy (0, 100, 500 000 μmol/L) applied to immunofluorescence observe morphological changes via SM-actin staining. Western blot was used detect...