A5001312226- Neuroblastoma Research and Treatments
- Advanced Breast Cancer Therapies
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Estrogen and related hormone effects
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Electrocatalysts for Energy Conversion
- Advanced Proteomics Techniques and Applications
- Electrochemical Analysis and Applications
- Machine Learning in Bioinformatics
- Computational Drug Discovery Methods
- Advanced Biosensing Techniques and Applications
- Fibroblast Growth Factor Research
- Radiopharmaceutical Chemistry and Applications
- Advanced Memory and Neural Computing
- Parathyroid Disorders and Treatments
- Cancer Research and Treatments
- Biomedical Research and Pathophysiology
- Retinoids in leukemia and cellular processes
- Functional Brain Connectivity Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Shanghai Jiao Tong University
2023-2025
Shanghai Sixth People's Hospital
2023-2025
RaNA Therapeutics (United States)
2024
Baylor College of Medicine
2014-2024
Yuhuangding Hospital
2024
Qingdao University
2024
Breast Center
2023
Prince of Wales Hospital
2023
University of Michigan
2008
Cornell University
1997
The thalamus plays a central and dynamic role in information transmission processing the brain.Multiple studies reveal increasing association between schizophrenia dysfunction of thalamus, particular medial dorsal nucleus (MDN), its projection targets.The thalamic connections to prefrontal cortex are interest, explicit vivo evidence this connection healthy humans is sparse.Additionally, recent neuroimaging has demonstrated disconnection among variety cortical regions schizophrenia, though...
Abstract Aims Fibroblast growth factor (FGF) 23 is a bone‐derived phosphaturic hormone that participates in the regulation of mineral metabolism and development chronic kidney disease. This study aimed to investigate association between FGF23 diabetic disease (DKD) community‐based prospective cohort. Materials Methods Of 7230 individuals who completed 4.6‐year follow‐up survey, 1614 with diabetes at baseline were included this study. Baseline serum levels measured by enzyme‐linked...
Invasive micropapillary carcinoma (IMPC) is a variant of breast with higher propensity for lymph node metastases compared invasive ductal (IDC). Retrospective analysis 636 IMPC and 297 735 IDC cases in the Surveillance, Epidemiology End Results database comparing disease-specific survival (DSS) overall (OS) between IDC. A percentage (52.0%) had nodal (34.6%). The 5-year DSS OS was 91.8% 82.9%, respectively 88.6% 80.5% IDC, respectively. For both oestrogen-receptor positivity associated...
Abstract Background There is growing evidence of a strong correlation between pain sensitivity and cognitive function under both physiological pathological conditions. However, the detailed mechanisms remain largely unknown. In current study, we sought to explore candidate genes common molecular underlying with transcriptome‐wide association study using recombinant inbred mice from BXD family. Methods The determined by Hargreaves' paw withdrawal test cognition‐related phenotypes were...
Abstract Endocrine therapies (ET) with cyclin-dependent kinase 4/6 (CDK4/6) inhibition are the standard treatment for estrogen receptor-α-positive (ER+) breast cancer, however drug resistance is common. In this study, proteogenomic analyses of patient-derived xenografts (PDXs) from patients 22 ER+ cancer demonstrated that protein kinase, membrane-associated tyrosine/threonine one (PKMYT1), a WEE1 homolog, estradiol (E2) regulated in E2-dependent PDXs and constitutively expressed when growth...
BackgroundThe relationship between fibroblast growth factor 21 (FGF21) and sweet taste perception preference in type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate this examine the neural responses of T2DM patients high-calorie (HCS) food pictures, further exploring its correlation with FGF21 levels. MethodsWe assessed 40 41 controls using classical scales. Subsequently, 11 HCS pictures were examined functional magnetic resonance imaging. levels measured...
Introduction Obesity is a complex and multifactorial disease that has affected many adolescents in recent decades. Clinical practice guidelines recommend exercise as the key treatment option for with overweight obesity. However, effects of virtual reality (VR) on physical brain health obese remain unclear. This study aims to evaluate VR exercises outcomes explore differences benefits between them. Moreover, we will apply multiomics analysis investigate mechanism underlying Methods randomised...
NF1 is a key tumor suppressor that represses both RAS and estrogen receptor-α (ER) signaling in breast cancer. Blocking pathways by fulvestrant (F), selective ER degrader, together with binimetinib (B), MEK inhibitor, promotes regression NF1-depleted
<div>Abstract<p>Endocrine therapies (ET) with cyclin-dependent kinase 4/6 (CDK4/6) inhibition are the standard treatment for estrogen receptor-α-positive (ER<sup>+</sup>) breast cancer, however drug resistance is common. In this study, proteogenomic analyses of patient-derived xenografts (PDXs) from patients 22 ER<sup>+</sup> cancer demonstrated that protein kinase, membrane-associated tyrosine/threonine one (PKMYT1), a WEE1 homolog, estradiol (E2)...
<p>A model of PKMYT1 gene transcription regulated by ERα and E2F factors</p>
<p>Immunoblotting of MCF7 EDR and Palbo-R cell lines to validate p53 protein knockdown</p>
<p>KIPA-SureQuant in T47D parental and palbociclib-resistant cells</p>
<p>Statistical analyses of data in Figures 6B, 6C, and S3.</p>
<p>WEE1 mRNA levels in relationship to anastrozole and palbociclib response</p>
<p>MCF7 EDR Palbo-R cell line displays cross-resistance to two other CDK4/6 inhibitors, in addition being palbociclib-resistant</p>
<p>The combination of RP-6306 and gemcitabine increases apoptosis activates DNA damage signaling in palbociclib-resistant T47D cells</p>
<p>Synergy and viability analysis of RP-6306 5-FU combination in T47D parental Palbo-R cells</p>
<p>Effect of RB1 knockdown on E2-induced gene expression</p>
<p>WEE1 mRNA and protein levels in ER+ breast cancer PDXs</p>
<p>This file contains 19 Supplementary Figures.</p>
<p>Effect of knocking down mutant p53 and re-expressing wild-type (WT) in T47D Palbo-R cells on synergy viability to the RP-6306 gemcitabine combination</p>