A5015248514- Pain Mechanisms and Treatments
- Sarcoma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- CAR-T cell therapy research
- EEG and Brain-Computer Interfaces
- Peptidase Inhibition and Analysis
- Neuroscience and Neural Engineering
- Advances in Oncology and Radiotherapy
- Melanoma and MAPK Pathways
- Neurological disorders and treatments
- Lung Cancer Research Studies
- Advanced Breast Cancer Therapies
Tianjin Medical University
2024-2025
Air Force Medical University
2025
Tianjin University
2024
Hubei University of Medicine
2017-2019
Taihe Hospital
2019
The First People’s Hospital of Lianyungang
2013
CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, underlying mechanisms remain challenging to fully investigate. Here, we used Genome-wide CRISPR/Cas9 library screening combined with single-cell sequencing screen molecules mediating identified METTL14 as determinant of sensitivity. Clinical samples datasets were analyzed in vitro vivo experiments performed...
With over 70 years of development, the Department Obstetrics and Gynecology at Tianjin Medical University General Hospital has evolved into a comprehensive center for clinical care, research, education, showcasing significant influence technical strength in field obstetrics gynecology. The department operates more than 200 beds, handles 260,000 outpatient emergency visits annually, performs nearly 10,000 surgeries each year. As final referral rescue complex critical cases Tianjin, excels...
The reconstruction of damaged neural circuits is critical for neurological repair after brain injury. Classical brain-computer interfaces (BCIs) allow direct communication between the and external controllers to compensate lost functions. Importantly, there increasing potential generalized BCIs input information into brains restore damage, but their effectiveness limited when a large injured cavity caused. Notably, it might be overcome by transplantation organoids region. Here, we construct...
In this study, we evaluated the efficacy and intestinal side effects of selective inhibitor vascular endothelial growth factor (VEGF) receptors, axitinib and/or dacarbazine (DTIC), in a B16F1 melanoma xenograft model. C57BL/6 mice were subcutaneously inoculated with cells. The study was randomized into four groups receiving either 0.5% carboxyl methylcellulose, DTIC, or combination DTIC axitinib. When experimental period complete, tumor tissues from each mouse excised, photographed weighed....
Integrated biochemical and biophysical signals regulate embryonic development. Correct neural tube formation is critical for the development of central nervous system. However, role microgravity in neurodevelopment its underlying molecular mechanisms remain unclear. In this study, effects stimulated (SMG) on human brain organoids are investigated. SMG impairs N-cadherin-based adherens junction formation, leading to defects associated with dysregulated self-renewal capacity neuroepithelial...