Several studies have shown that the increased expression of delta–like noncanonical Notch ligand 1 (DLK-1) is associated with more aggressive tumor characteristics in patients glioblastoma. The aim study was to estimate diagnostic and prognostic values DLK-1 serum levels glioblastoma patients. Material Methods . included 39 newly diagnosed level evaluated paired cerebrospinal fluid samples before starting chemoradiotherapy (CRT). All received combined modality treatment. blood additionally...

Purpose: To modernize software for calculation and optimization of isoeffective absorbed dose distributions in a homogeneous media when planning fast neutron therapy malignant tumours. Material Methods: The updated system was applied to patients with two localisations, breast cancer (BC) head neck (HNC). study included data from 12 patients, which 7 were primary locally advanced 5 cancer. In BC, comprehensive treatment performed. Patients tumours the region underwent neutron-photon radiation...

The analysis of clinical use neutron therapy with 6 MeV fast neutrons compared to conventional radiation was carried out. experience using and mixed photon in patients different radio-resistant malignant tumors shows the necessity further studies development novel approaches densely-ionizing radiation. results dosimetry radiobiological have been basis for planning programs therapy. Clinical trials over past 30 years shown that successfully destroys cancers, including salivary gland tumors,...

The purpose of the study was to evaluate efficacy neutron therapy (NT) for salivary gland cancer and recurrent breast cancer. Material Methods. included 130 patients with 125 Fast using U-120 cyclotron given group. Patients control group received standard radiotherapy (external beam radiotherapy). Results. Among cancer, a recurrence rate significantly lower in who postoperative course NT compared (21.1 vs 45 %, p<0.05). five-year overall survival rates were 73.8 ± 9.5 % 43.2 9.4 group,...

The purpose of this study was to analyze the results combined modality treatment and radiation therapy using 6.3 MeV fast neutrons for salivary gland cancer prognostically unfavorable thyroid cancer. group comprised 127 patients with 46 cancer, who received neutron alone in combination surgery. obtained demonstrated that including led encouraging local control cancers.

Цель исследования. Изучить влияние эндопротезирования с применением имплантатов из никелида титана на течение процессов заживления раневой поверхности после удаления опухолей полости носа и околоносовых пазух возможность управления последними. Материалы методы. В исследование вошли 60 пациентов, получавших комбинированное лечение по поводу злокачественных придаточных Т3-4N0-1M0 в НИИ онкологии г. Томска 2002 2021 гг. включительно. Все пациенты были подразделены 3 группы соответствии видом...

The results of the effective use magnetic laser therapy in treatment and rehabilitation cancer patients were presented. effect magnetic-laser radiation-induced reactions with head neck breast was analyzed. High efficiency lymphedema lymphorrhea postoperative period proved. gastric after surgical These data indicate a high effectiveness different physical methods patients.

High-grade malignant gliomas (WHO grade G III–IV) account for more than 50% of all primary brain tumors. Despite aggressive treatment, survival rates are still very low with a median reported no 1.5 years.Radiation therapy is an integral part the combined but often does not influence lethally on resistant tumor cells. Thereby, in recent decades there has been active search novel approaches to treatment (chemotherapeutic drugs, biological modifiers, local hyperthermia). Experimental data...

The results of the combined modality treatment including neutron therapy for patients with resistant malignant tumors were presented. Efficacy was assessed using disease-free and 5-year survival rates. Neutron used alone or as a combination shown to be more effective than photon therapy. A comprehensive program prevention acute radiation-induced damages devised.

Despite the achievements in current strategies for treatment, prognosis malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be most effective and universal modifier of radiotherapy chemotherapy. Preliminary treatment outcomes 28 with newly diagnosed (23) recurrent (5) high-grade gliomas were presented. All received multimodality including surgery, thermoche-moradiotherapy followed by 4 cycles adjuvant endured thermochemoradiotherapy well. A complication,...

Purpose: to summarize available data on the diagnostic value of various circulating biomarkers for detection glioblastoma recurrence. Material and Methods. A literature search was conducted using PubMED ExoCarta SILVA databases. Results. Glioblastoma multiforme (GBM) is most common glioma in adults with an unfavorable prognosis. Treatment tumor recurrence can improve survival patients. Neuroimaging standard method diagnosing brain However, a neuroimaging clearly distinguish between pseudo...

The goal of radiotherapy is to maximize the radiation dose abnormal cancer cells while preventing damage healthy tissue. in neutron therapy, optimum regime treatment uncertain date. purpose study develop a set methodological approaches that ensure permissible frequency and severity radiation-induced reactions patients subjected neutron-photon therapy (NFt) using u-120 cyclotron. Material methods. We used dependence relative biological effectiveness (RBE) neutrons on time-dose-fractionation...

The study group comprised 91 patients with nasal cavity cancer and paranasal sinuses who received the combined modality treatment use of 6.3 MeV fast neutrons generated within U-120 cyclotron. method for locally advanced malignant tumors was found to be more effective compared conventional in terms 5-year overall disease-free survival rates.

A new technique of concurrent chemoradiotherapy and local electromagnetic hyperthermia for treatment patients with newly diagnosed glioblastoma was developed at the Cancer Research Institute Tomsk National Medical Center. total 20 received temozolamide hyperthermia. Local performed using Celsius TCS device, 2 times a week (8–10 sessions). All tolerated well. The most common toxicity profile thermochemoradiotherapy hematological neurological. It should be noted that no neurological found in...

The purpose of this study was to analyze the results combined modality treatment and radiation therapy using 6.3 MeV fast neutrons c. included 45 patients with thyroid gland cancers who received alone use generated within U-120 cyclotron. clinical trial neutron-photon used in combination surgery for aggressive forms cancer showed feasibility increasing effectiveness due reduction incidence local recurrences. In addition, satisfactory tolerance absence severe specific complications dictate...

The study group comprised 124 patients with salivary gland cancer and 46 thyroid who received the combined modality treatment radiotherapy alone use of 6.3 MeV fast neutrons generated within U-120 cyclotron. radiation therapy allow encouraging long-term results to be achieved for cancers.

Obvious advantage of IORT (intraoperative radiotherapy) is that the radiation source delivered directly to bed tumor during surgery, thus avoiding negative impact on skin, subcutaneous tissue and reducing risk fibrosis. Sinonasal tumors—a convenient object for intraoperative radiotherapy application (surface location, relatively small size tumors, good operational access). The surface location comparatively neoplasms, access provide an efficient accurate transfer electron beam postoperative...

The treatment of patients with glioblastoma continues to be one the greatest challenges. Glioblastoma is most aggressive malignant primary brain tumor and lethal among all cancers. Despite advances in standard treatment, prognosis for remains poor, therefore, development novel strategies required. Material methods. Our study included 30 newly diagnosed glioblastoma, who underwent concurrent chemoradiotherapy local hyperthermia. Results. median disease-free overall survival rates were 9.6...

Conclusion:Herein c-Myc acts as a key master regulator of in vitro migration, invasion and radioresistance.In fact, depletion alone seems to be sufficient block the pro-metastatic abilities radiosensitize ERMS cells.In addition, our data suggest important, but not essential, controlling molecular machinery responsible for cancer neo-angiogenesis.In conclusion these strongly that targeting can tested promising strategy an anti-cancer therapy.