A5019587279- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Photonic and Optical Devices
- Molecular Junctions and Nanostructures
- Gas Sensing Nanomaterials and Sensors
- Biosensors and Analytical Detection
- Advanced Fiber Optic Sensors
- Nanowire Synthesis and Applications
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Advanced Sensor and Energy Harvesting Materials
- Advanced Surface Polishing Techniques
- Nanoparticles: synthesis and applications
- Electrochemical Analysis and Applications
- Advanced Nanomaterials in Catalysis
- Advanced Photocatalysis Techniques
- Graphene and Nanomaterials Applications
- Biocrusts and Microbial Ecology
- Plasmonic and Surface Plasmon Research
- Advanced machining processes and optimization
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Advanced Drug Delivery Systems
- Advanced Chemical Sensor Technologies
Symbiosis International University
2018-2025
Centre de Nanosciences et de Nanotechnologies
2025
Rutgers, The State University of New Jersey
2010-2024
Savitribai Phule Pune University
1997-2023
D.Y. Patil University
2021
Sungkyunkwan University
2008-2017
Rutgers Cancer Institute of New Jersey
2010-2017
Johnson University
2017
Suwon Research Institute
2015
Cancer Institute of Florida
2010
DNA damage activates signaling pathways that lead to modification of local chromatin and recruitment repair proteins. Multiple proteins having ubiquitin ligase activity are recruited sites damage, where they ubiquitinate histones other substrates. This damage-induced histone ubiquitination is thought play a critical role in mediating the response. We now report polycomb protein BMI1 rapidly it persists for more than 8 h. The sustained localization dependent on intact ATM ATR requires H2AX...
New hydrophilic 2D graphene oxide (GO) nanosheets with various oxygen functional groups were employed to maintain high sensitivity in highly unfavorable environments (extremely humidity, strong acidic or basic). Novel one-headed polymer optical fiber sensor arrays using GO and hydrophobic reduced (rGO) carefully designed, leading the selective sensing of volatile organic gases for first time. The two physically different surfaces rGO could provide ability distinguish between tetrahydrofuran...
Phosphorus-doped double-layered graphene field-effect transistors (PDGFETs) show much stronger air-stable n-type behavior than nitrogen-doped FETs (NDGFETs), even under an oxygen atmosphere, due to strong nucleophilicity, which may lead real applications for channels. Detailed facts of importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher...
Abstract Introduction. For patients with non-small cell lung cancer (NSCLC) to benefit from ALK inhibitors, sensitive and specific detection of genomic rearrangements is needed. break-apart fluorescence in situ hybridization (FISH) the U.S. Food Drug Administration approved standard-of-care diagnostic assay, but identification by other methods reported NSCLC cases that tested negative for FISH suggests a significant false-negative rate. We report here large series assayed...
Fusions involving the oncogenic gene RET have been observed in thyroid and lung cancers. Here we report alterations, including amplification, missense mutations, known fusions, novel rearrangements breast cancer. Their frequency, potential, actionability cancer are described. Two out of eight fusions (NCOA4-RET a RASGEF1A-RET fusion) amplification were functionally characterized shown to activate kinase drive signaling through MAPK PI3K pathways. These can induce transformation...
Abstract Industry 5.0 (I5.0) is all set to come into the limelight when 4.0 (I4.0) has not yet fully matured and still gaining ground in growing economies. The general notion of I5.0 discussed existing literature on subject domain, but there are no adequate studies that examine its implications. Therefore, systematic review method adopted to: explore understanding I5.0; identify opportunities for highlight challenges implementation; investigate effects economic, environmental, social pillars...
UHRF1 [ubiquitin-like protein, containing PHD (plant homeodomain) and RING finger domains 1] is required for cell cycle progression epigenetic regulation. In the present study, we show that depleting cancer cells of causes activation DNA damage response pathway, arrest in G2/M-phase apoptosis dependent on caspase 8. The depleted illustrated by: phosphorylation histone H2AX Ser139, CHK (checkpoint kinase) 2 Thr68, CDC25 (cell division control 25) Ser216 CDK1 (cyclin-dependent kinase 1) Tyr15....
Extensive research has been conducted during 20th century to discover renewable natural polymers that are sustainable. Cellulose represents one such biomaterial which is abundant, renewable, and biodegradable. Both plant microbial biomass can be processed make cellulose. Bacterial cellulose (BC) a prospective polymer produced by certain bacteria their growth phase. BC hydrophilic biopolymer, fibrous (20–100 nm diameter), biocompatible. In contrast cellulose, the benefit of being in form,...
A facile, one pot, completely green, and cheap route for the synthesis of gold nanoparticles (AuNPs) has been developed by using locust bean gum (LBG), both as a reducing stabilizing agent. Synthesized AuNPs were characterized UV-vis spectroscopy, TEM, XRD, dynamic light scattering analysis (DLS) EDAX. characteristic surface plasmon peak at 537 nm confirmed formation AuNPs. found to be an efficient catalyst reduction 4-nitrophenol (4-NP) 4-aminophenol (4-AP). The reaction follows...
Purpose: Many patients with BRAFV600E mutant melanoma treated BRAF inhibitors experience a rapid response, but ultimately develop resistance. Insight into the mechanism of resistance is critical for development more effective treatment strategies.Experimental Design: Comprehensive genomic profiling serial biopsies was performed in patient metastatic who developed to vemurafenib. An AGAP3-BRAF fusion gene, identified vemurafenib-resistant tumor, expressed cell lines, and its effect on drug...
Abstract This paper reports a biosensor based on MoS 2 -graphene (MG) composite that can measure the parathyroid hormone (PTH) concentration in serum samples from patients. The interaction between PTH and MG was analysed via an electrochemical sensing technique. functionalized using l -cysteine. Following this, could be covalently immobilized electrode. properties of were evaluated scanning electron microscopy, high-resolution transmission X-ray diffraction, Raman spectroscopy, photoelectron...
Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation reactive oxygen species (ROS). In addition, also involved the modulation of fibroblasts proliferation. However, regulatory function wound repair human is not yet clearly elucidated. To investigate roles healing process keratinocytes, three MAAs,...
Water scarcity is a critical global challenge exacerbated by population growth and industrialization. Contamination of water sources diverse pollutants poses significant threats to public health. Consequently, there an urgent need for the development advanced technologies capable purifying detoxifying water. Beyond safeguarding health, these purification play pivotal role in enabling recycling meet demands during periods limited availability.This review provides comprehensive overview...
Recently, many studies have been focused on the development of fiber optic sensor systems for various gases and vapors. In present study, an intrinsic polymer optical (POF) using graphene is described purpose acetone vapor sensing first time. Observations continuous measurement in dehydrated air are presented. The principle operation transduction relies dependence reflectance geometric properties sensitive over layered when molecules adsorbed film. For same CVD synthesized film was...
The paper reports a rapid and single pot synthesis of polysaccharide stabilized silver nanoparticles (Ag NPs). ability Ag NPs to catalyze the reduction hydrogen peroxide (H2O2) is successfully explored for development an optical fiber H2O2 sensor in concentration range 10−2 10−6 M.
The unexpected nuclear accidents have provided a challenge for scientists and engineers to develop sensitive detectors, especially alpha radiation. Due the high linear energy transfer value, sensors designed detect such radiation require placement in close proximity source. Here we report morphological changes optical responses of artificially DNA thin films response exposure as observed by an atomic force microscope, Raman reflectance spectroscopes. In addition, discuss feasibility film...