A5085290644- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Urinary Bladder and Prostate Research
- Ubiquitin and proteasome pathways
- Urinary and Genital Oncology Studies
- RNA Research and Splicing
- Immune cells in cancer
- Cardiomyopathy and Myosin Studies
- Axon Guidance and Neuronal Signaling
- Urologic and reproductive health conditions
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Mass Spectrometry Techniques and Applications
- Cancer, Lipids, and Metabolism
- Lymphatic Disorders and Treatments
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Immune responses and vaccinations
Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers
2020-2024
Kyushu University
2010-2018
University of British Columbia
2015-2016
Hiroshima University
2015
St. Petersburg Institute of Bioregulation and Gerontology
2013
Kameda Medical Center
2011
Ministry of Defense
2010-2011
Nippon Steel Yawata Memorial Hospital
2011
City of Hope
2010
Red Cross Hospital
2008
Systemic therapy for advanced bladder cancer has not changed substantially in more than 2 decades and mortality rates remain high. The recognition of HER2 over expression made a promising therapeutic target. T-DM1, new drug consisting the antibody trastuzumab conjugated with cytotoxic agent, been shown breast to be superior trastuzumab. We tested T-DM1 preclinical models cancer.We evaluated effect compared different vitro vivo expressing cancer.RT4V6 was highest cell line it showed higher...
Interleukin-17A (IL-17A)-producing γδ T cells differentiate in the fetal thymus and reside peripheral tissues, such as lungs of naïve adult mice. We show here that naturally occurring play a protective role lung at very early stage after systemic infection with Candida albicans. Selective depletion neutrophils by vivo administration anti-Ly6G monoclonal antibody (MAb) impaired fungal clearance more prominently than kidney 24 h intravenous C. Rapid transient production IL-23 was detected 12...
Research Article18 January 2018Open Access Source DataTransparent process SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1 James W Peacock Vancouver Prostate Centre, Vancouver, BC, Canada Department of Urologic Sciences, University British Columbia, Search for more papers this author Ario Takeuchi Urology, Graduate School Medical Kyushi University, Fukuoka, Japan Norihiro Hayashi The Jikei Medicine, Tokyo, Liangliang Liu Kevin J Tam Nader Al...
We determined whether intravesical recurrence is affected by inhibition of androgen signaling among men with nonmuscle invasive bladder cancer.We examined the rate treated or without suppression therapy deprivation for prostate cancer 5α-reductase inhibitor dutasteride benign prostatic hyperplasia.We studied 228 men, including 32 and 196 therapy. During a median followup 3.6 3.0 years developed in 4 (12.5%) 59 (30.1%) therapy, respectively. On multivariate analysis multiple tumors (HR 1.82,...
Intravesical inoculation of Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been used for the treatment bladder cancer. Recent studies implied requirement neutrophil infiltration antitumor effect. In this study, we found that IL-17 was produced in after BCG treatment, preceding neutrophils. Neutrophils were reduced IL-17-deficient mice, which BCG-induced effect against intravesically inoculated cancer abolished. Notably, level production and number neutrophils BCG-treated γδ...
Abstract BACKGROUND Taxanes, including docetaxel, are currently the only cytotoxic chemotherapeutic agents proven to confer survival benefit in patients with castration‐resistant prostate cancer (CRPC). However, merits of taxanes remain modest, and efforts needed improve their therapeutic efficacy. METHODS We evaluated sensitivity cells various using cytotoxicity assays. Gene protein expression levels were by quantitative real‐time polymerase chain reaction Western blotting analysis,...
Currently, the optimal sequential use of androgen receptor (AR) axis-targeted agents and taxane chemotherapies remains undetermined. We aimed to elucidate resistance status between taxanes enzalutamide, functional role AR axis. Enzalutamide-resistant 22Rv1 cells showed collateral taxanes, including docetaxel cabazitaxel. However, taxane-resistant no enzalutamide; expressed comparable protein levels full-length variants. Knockdown both variants rendered sensitive whereas knockdown sensitized...
Serum testosterone suppression during androgen deprivation therapy has been reported to affect the efficacy of therapy. However, factors impacting hormonal variations remain unclear. Therefore, in this study we investigated significance missense polymorphisms gene encoding GNRH men treated with primary for metastatic prostate cancer.This included 80 Japanese patients cancer available serum levels We examined association GNRH1 (rs6185, S20W) and GNRH2 (rs6051545, A16V) clinicopathological...
Phorbol 12-myristate 13-acetate (PMA) induces cellular apoptosis in prostate cancer cells, the growth of which is governed by androgen/androgen receptor (AR) signaling, but mechanism PMA exerts this effect remains unknown. Therefore, study, we investigated mechanistic action cells with regard to AR. We showed that decreased E2F1 as well AR expression androgen-dependent LNCaP cells. Furthermore, activated JNK and p53 resulting induction apoptosis. In androgen deprivation a novel anti-androgen...
BACKGROUND LIM and SH3 domain protein 1 (LASP1) has been implicated in several human malignancies shown to predict PSA recurrence prostate cancer. However, the anti‐tumor effect of LASP1 knockdown association between androgen receptor (AR) remains unclear. The aim this study is clarify significance as a target for cancer, test silencing vivo using antisense oligonucleotides (ASO). METHODS A tissue microarray (TMA) was performed characterize differences expression cancer treated after hormone...
Abstract Objectives This study aimed to compare the safety and efficacy of three different laser prostate vaporization surgeries, which were photoselective (PVP), diode (DVP), thulium (ThuVAP), for treatment benign prostatic hyperplasia (BPH) in a randomized clinical trial. Methods A total 71 consecutive patients with BPH included; 23 treated PVP, DVP, 25 ThuVAP. Patients evaluated disease‐related symptomatic questionnaires, Quality Life (QOL) Index, maximum urinary flow rate ( Q max ) 12...
The progression of prostate cancer to metastatic and castration-resistant disease represents a critical step. We previously showed that protein kinase C (PKC) activation followed by Twist1 androgen receptor (AR) induction played role in castration resistance, but the precise molecular mechanism remains unknown. This study aimed elucidate relevant mechanism, focusing on NF-κB transcription factor. examined activity after PKC inhibition, expression AR inhibition human cells. also investigated...
This study aimed to evaluate the efficacy and safety of Vibegron for treatment residual overactive bladder (OAB) symptoms after laser vaporization prostate (photo-selective prostate, contact thulium vaporization).
Abstract Objectives This study aimed to compare the safety and efficacy of laser vaporization with 532 nm GreenLight High Performance System (HPS) 120 W (PVP) 980 diode 300 (CVP) for treatment benign prostatic hyperplasia (BPH) in a prospective, single‐center, randomized clinical trial. Methods A total 153 consecutive patients symptomatic BPH were included; 79 treated PVP 74 CVP. Patients assessed preoperatively at 3, 6, 12 months postoperatively using International Prostate Symptom Score,...
You have accessJournal of UrologyBladder Cancer: Basic Research I1 Apr 2012563 IL-17 PRODUCTION BY γδ T CELLS IS IMPORTANT FOR THE ANTITUMOR EFFECT OF MYCOBACTERIUM BOVIS BACILLUS CALMETTE-GUERIN TREATMENT AGAINST BLADDER CANCER Takashi Dejima, Ario Takeuchi, Masatoshi Eto, Tatsuya Nakatani, Yasunobu Yoshikai, and Seiji Naito DejimaTakashi Dejima Fukuoka, Japan More articles by this author , TakeuchiArio Takeuchi EtoMasatoshi Eto Kumamoto, NakataniTatsuya Nakatani Osaka, YoshikaiYasunobu...
Hemorrhagic cystitis often arises after cyclophosphamide (CYP) administration. As yet, however, the mechanism involved in its pathogenesis is unknown. In this study, it was found that Fc receptor γ chain (FcRγ)- caspase recruitment domain-containing protein 9 (CARD9)-dependent pathway rather than myeloid differentiation primary response gene 88 (MyD88)-dependent of acute CYP-induced mice. Rapid and transient production interleukin (IL)-6 IL-1β detected bladder at 4 hr, preceding IL-23 IL-17A...
Background/Aim: Salvage androgen-deprivation therapy (ADT) is standard treatment for recurrent prostate cancer after curative therapy. However, the prognostic impact of different modalities on time to castration resistance remains unclear. In this study, we investigated prognosis men treated with salvage ADT initial radical prostatectomy or radiotherapy cancer. Patients and Methods: Between 2000 2013, 149 Japanese who were initially (n=95) (n=54) subsequently disease recurrence enrolled in...