A5009266416- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Patient Satisfaction in Healthcare
- Streptococcal Infections and Treatments
- Pharmaceutical studies and practices
- Urinary Tract Infections Management
- Respiratory viral infections research
- Pediatric Urology and Nephrology Studies
- Emergency and Acute Care Studies
- Asthma and respiratory diseases
- Public Health Policies and Education
- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Child and Adolescent Health
- Neonatal Respiratory Health Research
- Pelvic floor disorders treatments
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- COVID-19 and Mental Health
- Respiratory and Cough-Related Research
- Healthcare Systems and Technology
- Inhalation and Respiratory Drug Delivery
- Urinary Bladder and Prostate Research
- Primary Care and Health Outcomes
- Escherichia coli research studies
University of British Columbia
2019-2024
Centre for Advancing Health Outcomes
2024
The objective of this study was to examine the aggregate rates antibiotic use at population level and compare these over time against historical averages identify effect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting control measures on community prescribing.We collected prescriptions physician office visits from January 1, 2016, July 21, 2020. We calculated monthly prescription stratified by sex, age group, profession, diagnosis type, class. looked rate as a moving...
Abstract Background With 90% of all antibiotics in Canada being used the community setting, tracking outpatient prescribing is integral to mitigate issue antimicrobial resistance. In 2005, a provincial programme was launched British Columbia (BC) disseminate information regarding judicious use antibiotics. These efforts include educational campaigns, updated practitioner guidelines and academic detailing. The impact stewardship on requires ongoing evaluation. Objectives This study examines...
Abstract Background Numerous studies have characterized the 13-valent pneumococcal conjugate vaccine (PCV13) programme’s beneficial effects on acute otitis media (AOM) and sinusitis (AS) rates in children; however, few examined impact adults. Objectives This retrospective cohort study evaluates overall effect of PCV13 immunization programme incidence AOM AS at population level. Methods Health administrative databases were linked to assess outpatient visits, hospitalizations antibiotic...
Abstract Background Infant antibiotic use is associated with increased risk of asthma. We examined the population impact exposure in first year life on burden pediatric asthma British Columbia, Canada, using simulation modeling. Methods performed a Bayesian meta-analysis empirical studies to construct dose-response equations between and (<19 years age) used administrative health data document trends infant (< 1 Columbia during 2001 2018 (the study period). An independently developed...
Antimicrobials are among the most prescribed medications in Canada, with over 90% of antibiotics outpatient settings. Seniors antimicrobials particularly vulnerable to adverse drug events and antimicrobial resistance. The extent inappropriate antibiotic prescribing Canadian medical practice, potential long-term trends this unknown. This study is first Canada examine quality across two large-scale provincial healthcare systems compare both quantity use seniors. Population-based analyses using...
Urinary tract infection (UTI) is one of the most common infections, has frequent recurrences, and may debilitate quality life. UTI considered recurrent if there are three individual cases within 12 months. The objective this study was to set a baseline for urinary infections (rUTI) in women, rUTI-associated antibiotic prescribing presence antimicrobial stewardship efforts.Data rUTI women were organized through provincial prescription database, physician billing system, consolidation file...
Despite decades of stewardship efforts to combat antimicrobial resistance and quantify changes in use, the quality antibiotic use British Columbia (BC) remains unknown. As overuse misuse antibiotics drives resistance, it is imperative expand surveillance examine prescriptions. In late 2019, Canadian expected rates prescribing were developed for common infections. These utilized gap between observed province BC. The data extracted matched physician billing systems using anonymized patient...
The COVID-19 pandemic affected access to care, and the associated public health measures influenced transmission of other infectious diseases. has dramatically changed antibiotic prescribing in community. We aimed determine impact resulting control on oral long-term care facilities (LTCFs) Alberta Ontario, Canada using linked administrative data. Antibiotic prescription data were collected for LTCF residents 65 years older Ontario from 1 January 2017 until 31 December 2020. Weekly rates per...
This retrospective cohort study is the first in North America to examine population-level appropriate antibiotic use for community-acquired pneumonia (CAP) older adults, by agent, dose and duration. With highest rates of CAP reported elderly populations, essential improve clinical outcomes. Given ongoing crisis antimicrobial resistance, understanding inappropriate prescribing integral direct community stewardship efforts.All outpatient primary care visits (aged ≥65 years) were identified...
Antibiotics remain the primary treatment for community acquired pneumonia (CAP), however rising rates of antimicrobial resistance may jeopardize their future efficacy. With higher disease reported in youngest populations, effective courses pediatric are paramount importance. This study is first to examine quality antibiotic use by agent, dose and duration.A retrospective cohort included all outpatient/primary care physician visits CAP (aged < 19 years) between January 1 2014 December 31...
Background: Urinary tract infections (UTI) are responsible for a significant portion of female, outpatient antibiotic prescriptions. Especially true in uncomplicated cases, where symptoms remain the cornerstone diagnosis, ensuring optimal choice agent, dose, and duration may mitigate future bacterial resistance lower likelihood adverse events and/or recurrence. This study is first Canada to examine quality prescribing females setting, UTI–by duration. Methods: All adult female residents...
Background Infant antibiotic use is associated with increased risk of asthma. We examined the population impact exposure in first year life on burden pediatric asthma British Columbia, Canada, using simulation modeling. Methods performed a Bayesian meta-analysis empirical studies to construct dose-response equations between and (&lt;19 years age) used administrative health data document trends infant (&lt;1 Columbia during 2001 2018 (the study period). An independently developed...
Background. Clostridioides difficile (CDI) is the most common cause of nosocomial diarrheal infections. Historically, metronidazole was first-line treatment, but guidelines now indicate oral vancomycin and fidaxomicin as primary antibiotics for initial episodes. A provincial stewardship program has operated in British Columbia (BC), since 2005. Since program's inception, surveillance antibiotic use been ongoing. However, this first study to review community-acquired CDI-indicated use....
Abstract Background Antibiotic prescribing in pediatric care is highly prevalent. Often children are prescribed antibiotics for conditions that commonly self-limiting and viral etiology such as upper respiratory tract infections. The purpose of this study was to examine the scope antibiotic British Columbia from 2013 2016 identify potential new provincial antimicrobial stewardship targets. Methods prescription data were extracted a database, linked demographic files order obtain patient age,...
Abstract Background Antibiotic prescribing in pediatric care is highly prevalent, and quite often children are prescribed for conditions which commonly self-limiting viral etiology. The purpose of this study was to examine the scope antibiotic by indication, from 2013 2016, identify potential new targets provincial antimicrobial stewardship efforts. Methods prescription data were extracted a database, linked physician billing order obtain diagnostic information. Prescription rates then...