A5075315423- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Health disparities and outcomes
- Obesity, Physical Activity, Diet
- Poisoning and overdose treatments
- Pain Management and Opioid Use
- Health Systems, Economic Evaluations, Quality of Life
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Smoking Behavior and Cessation
- HIV, Drug Use, Sexual Risk
- Preterm Birth and Chorioamnionitis
- Prenatal Substance Exposure Effects
- Infective Endocarditis Diagnosis and Management
- Urban Transport and Accessibility
- Employment and Welfare Studies
- Congenital Anomalies and Fetal Surgery
- Healthcare Policy and Management
- Global Health Care Issues
- Health Policy Implementation Science
- Palliative Care and End-of-Life Issues
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Empathy and Medical Education
- Patient-Provider Communication in Healthcare
- HIV/AIDS Research and Interventions
University of Colorado Denver
2023-2025
Denver Health Medical Center
2024-2025
Health and Hospital Corporation
2024-2025
University of Colorado Anschutz Medical Campus
2024-2025
Boston Medical Center
2022-2025
Boston University
2022-2025
Paris Junior College
2024
Michigan Medicine
2021
University of Michigan
2012-2020
National Institutes of Health
2016
Neighborhood environments may influence the risk for developing type 2 diabetes mellitus (T2DM), but, to our knowledge, no longitudinal study has evaluated specific neighborhood exposures.To determine whether long-term exposures physical and social environments, including availability of healthy food activity resources levels cohesion safety, are associated with incident T2DM during a 10-year period.We used data from Multi-Ethnic Study Atherosclerosis, population-based cohort adults aged 45...
Abstract Background Given the opioid overdose crisis, surveillance of evolving use patterns is critical to effective deployment mitigation strategies. The National Survey on Drug Use and Health (NSDUH) provided first annual US estimate illicitly manufactured fentanyl (IMF) in 2022. However, as a household survey, NSDUH may not capture full extent population heroin IMF use. We compare estimates past-year correlates Non-Medical Prescription Drugs (NMURx) survey which employ an alternate...
Importance Local-level data are needed to understand whether the relaxation of X-waiver training requirements for prescribing buprenorphine in April 2021 translated increased treatment. Objective To assess was associated with changes number clinicians waivered and who prescribe opioid use disorder patients receiving Design, Setting, Participants This serial cross-sectional study uses an interrupted time series analysis 2020-2022 from HEALing Communities Study (HCS), a cluster-randomized,...
Importance Buprenorphine treatment of opioid use disorder (OUD) is safe and effective, but withdrawal during initiation associated with poor retention in care. As fentanyl has replaced heroin the drug supply, case reports surveys have indicated increased concern for buprenorphine-precipitated (PW); however, some observational studies found a low incidence PW. Objective To estimate buprenorphine PW assess factors among emergency department (ED) or hospitalized patients. Design, Setting,...
Electronic cigarette (e-cigarette) use has increased rapidly in recent years. Given the unknown effects of e-cigarette on smoking behaviors, regulation become subject considerable controversy. In absence longitudinal data documenting long-term behavior and population outcomes, computational models can guide future empirical research provide insights into possible prevalence over time.
Federal regulations restrict methadone for opioid use disorder (OUD) treatment to licensed programs (OTPs). However, providers in other settings can administer withdrawal under the "72-hour rule" while linking further care. Prior work has demonstrated that initiation a low-barrier bridge clinic is associated with high OTP linkage and 1-month retention rates. We describe 2 novel applications of 72-hour rule which management facilitated inpatient hospitalization outpatient buprenorphine induction.
Methadone for opioid use disorder (OUD) treatment is restricted to licensed programs (OTPs) with substantial barriers entry. Underutilized regulations allow non-OTP providers administer methadone withdrawal up 72 h while arranging ongoing care. Our low-barrier bridge clinic implemented a new pathway treat and facilitate OTP linkage utilizing the "72-hour rule."Patients presenting hospital-based were evaluated OUD, withdrawal, goals. Eligible patients offered management rapid referral. OTPs...
The amnion is a specialized tissue in contact with the amniotic fluid, which constantly changing state. To investigate importance of epigenetic events this physiology and pathophysiology pregnancy, we performed genome‐wide DNA methylation profiling human from term (with without labor) preterm deliveries. Using Illumina Infinium HumanMethylation27 BeadChip, identified genes exhibiting differential associated normal labor birth. Functional analysis differentially methylated revealed...
Medications for opioid use disorder (MOUD) increase retention in care and decrease mortality during active treatment; however, information about the comparative effectiveness of different forms MOUD is sparse. Observational studies are subject to many types bias; a robust framework minimize bias would improve quality evidence. This paper discusses target trial emulation as conduct with administrative data. Using examples from our planned research project comparing buprenorphine-naloxone...
In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk. We aimed to evaluate relationship between Colorado's drug-related legal penalties, risk of overdose, and substance use patterns. used concept mapping — a mixed-methods approach develop conceptual understanding an issue from community lens engage with people living and/or lived experience system, use, their loved ones, service providers. facilitated...
Abstract Background and aims It is unclear if findings from randomized controlled trials (RCT) of medications for opioid use disorder apply to real‐world settings. We estimated the effectiveness buprenorphine‐naloxone (BUP‐NX) versus extended‐release naltrexone (XR‐NTX) on treatment interruption in a RCT an observational study based data. Design Target trial emulation harmonize protocol statistical analyses X:BOT (target trial) (observational emulation). Baseline was randomization target...
In response to the U.S. overdose crisis, many states have increased criminal penalties for drug possession, particularly fentanyl. This study sought qualitatively explore diverse community perspectives on increasing legal in Colorado fentanyl possession (House Bill 22-1326) and broader role of system addressing substance use prevention. We conducted 31 semi-structured interviews 2023 with leaders directly working people who drugs, individuals lived experience system, law enforcement...
The alpha2-agonist xylazine is an increasingly common adulterant of illicitly manufactured fentanyl. A potential withdrawal syndrome (XWS) poorly characterized. We assessed for XWS. conducted a retrospective cohort study all hospitalized patients with urine GC-MS testing performed at three academic hospitals in Philadelphia, PA from 3/2022-2/2023. used linear and logistic regression to compare peak systolic blood pressure, heart rate, intensive care unit (ICU) admissions vs. without...
Research has shown that recessions are associated with lower cardiovascular mortality, but unemployed individuals have a higher risk of disease (CVD) or death. We used data from 8 consecutive examinations (1985-2011) the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, modeled fixed-effect panel regressions, to investigate simultaneously associations CVD factors employment status and macroeconomic conditions prevalent state where individual lives. found had levels blood...
Home foreclosures can precipitate declines in health among the individuals who lost their homes. Whether home "spillover" to affect of other neighborhood residents is largely unknown. Using longitudinal data from Multi-Ethnic Study Atherosclerosis that were linked foreclosure 2005 2012, we assessed whether greater exposure was associated with temporal changes 3 objectively measured cardiometabolic risk factors: body mass index, systolic blood pressure, and fasting glucose level. We used...
Objective: Outdoor smoking bans have been implemented to reduce secondhand smoke exposure and cigarette littering. We aimed explore outdoor behaviours, littering, support towards a recently enacted ban in Baja California, Mexico. Methods: From October 2013 April 2014 representative sample of 800 adults from urban areas California was surveyed obtain information on demographics, status, opinion general specific locations, perceptions habits regarding Descriptive statistics Poisson regression...
Benzodiazepine-involved overdose deaths are rising, driven by increasing use of nonprescribed benzodiazepine pills. For patients who wish to stop use, rapid inpatient tapers typically the only option treat withdrawal. Substance disorder bridge clinics can provide high-touch care needed manage outpatient in at high risk due other substance disorders.
Background Occupation is often used as an indicator of socioeconomic position (SEP) in epidemiological studies, although it unclear whether variation SEP within a single occupational group associated with health outcomes, including adiposity measures. Methods We created multidimensional index using principal component analysis based on self-reported data from 36 704 female teachers Mexico 2008 to 2011. Multivariable Poisson regression models robust variance were evaluate cross-sectional...