A5025528921- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Colorectal Cancer Treatments and Studies
- Economic and Financial Impacts of Cancer
- Optimism, Hope, and Well-being
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer-related cognitive impairment studies
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Surgical Treatments
- Healthcare professionals’ stress and burnout
- Prostate Cancer Treatment and Research
- Colorectal and Anal Carcinomas
- Advanced Breast Cancer Therapies
- Nutrition and Health in Aging
- Ethics in medical practice
- Childhood Cancer Survivors' Quality of Life
- Multiple and Secondary Primary Cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Patient-Provider Communication in Healthcare
Prisma Health
2012-2024
University of South Carolina
2021-2024
Ochsner Medical Center
2000-2023
National Cancer Institute
2011-2021
NRG Oncology
2021
Neurology Centers of the Carolinas
2011-2021
Dana-Farber Cancer Institute
2005-2015
American Cancer Society
2015
American Society of Clinical Oncology
2015
National Institutes of Health
2015
PURPOSE: To evaluate whether treatment with single-agent docetaxel would result in longer survival than best supportive care patients non–small-cell lung cancer who had previously been treated platinum-based chemotherapy. Secondary end points included assessment of response (docetaxel arm only), toxicity, and quality life. PATIENTS AND METHODS: Patients performance statuses 0 to 2 stage IIIB/IV either measurable or evaluable lesions were eligible for entry onto the study if they undergone...
Data from multilocus enzyme electrophoresis of bacterial populations were analyzed using a statistical test designed to detect associations between genes at different loci. Some species (e.g., Salmonella) found be clonal all levels analysis. At the other extreme, Neisseria gonorrhoeae is panmictic, with random association Two intermediate types population structure also found. meningitidis displays what we have called an "epidemic" structure. There significant loci, but this arises only...
Purpose Increased circulating tumor cells (CTCs; five or more CTCs per 7.5 mL of whole blood) are associated with poor prognosis in metastatic breast cancer (MBC). A randomized trial patients persistent increase tested whether changing chemotherapy after one cycle first-line would improve the primary outcome overall survival (OS). Patients and Methods MBC who did not have increased at baseline remained on initial therapy until progression (arm A). initially that decreased 21 days B)....
In 1990, fluorouracil (FU) plus levamisole for 1 year became standard adjuvant treatment patients with high-risk stages II and III colon cancer. Intergroup (INT) 0089 assessed the relative contributions of leucovorin in such patients.From 1988 to 1992, 3,794 were randomly assigned. Experimental consisted one three chemotherapy regimens: low-dose FU (Mayo Clinic; LDLV) regimen, high-dose (Roswell Park; HDLV) (LDLV LEV) each administered 30 32 weeks. The control arm was (LEV) year.After a...
Combination programmed cell death protein 1/cytotoxic T-cell lymphocyte-4-blockade and dual BRAF/MEK inhibition have each shown significant clinical benefit in patients with
<h3>Importance</h3> Total neoadjuvant therapy (TNT) is often used to downstage locally advanced rectal cancer (LARC) and decrease locoregional relapse; however, more than one-third of patients develop recurrent metastatic disease. As such, novel combinations are needed. <h3>Objective</h3> To assess whether the addition pembrolizumab during after chemoradiotherapy can lead an improvement in (NAR) score compared with treatment FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) alone. <h3>Design,...
To evaluate whether treatment with single-agent docetaxel would result in longer survival than best supportive care patients non-small-cell lung cancer who had previously been treated platinum-based chemotherapy. Secondary end points included assessment of response (docetaxel arm only), toxicity, and quality life.
PURPOSE This prospective multicenter randomized trial was performed to compare the effectiveness and safety of intravenous (i.v.) vinorelbine tartrate (Navelbine [NVB]; Burroughs Wellcome Co, Research Triangle Park, NC) with i.v. melphalan (Alkeran [ALK]; Co) in a heavily pretreated population patients anthracycline-refractory advanced breast cancer (ABC). Efficacy end points included time disease progression (TDP), treatment failure (TTF), survival, tumor response rates, quality life (QL)...
We evaluated the efficacy of gemcitabine versus and carboplatin in patients with advanced non-small-cell lung cancer (NSCLC) a performance status (PS) 2 assessed if tumoral RRM1 ERCC1 protein levels are predictive response to therapy.A randomized phase III trial was conducted community-based oncology practices. Tumor specimens were collected priori shipped single laboratory for blinded determination situ expression by an automated quantitative immunofluorescent-based technology.One hundred...
356154 Background: Combinations of immune checkpoint inhibitors (CPI) blocking PD-1 and CTLA-4 or BRAF/MEK have both shown significant antitumor efficacy overall survival (OS) benefit in patients (pts) with BRAFV600-mutant metastatic melanoma (MM), leading to broad regulatory approval. Little prospective data exists guide the choice one over other as initial therapy preferred treatment sequence this population. The DREAMseq Trial was designed compare toxicity nivolumab/ipilimumab (N/I)...
Lung cancer increases in incidence with increasing age and is the leading cause of death United States. While mass screening for lung not indicated, selective high-risk target groups may be beneficial. We tested hypothesis that initially seen at a less advanced stage using cases (N = 22874) from Centralized Cancer Patient Data System. The percent patients local disease increased 15.3% those aged 54 years or younger, to 19.2% 55 64 years, 21.9% 65 74 25.4% 75 older. distant decreased 48.7%,...
PURPOSE This prospective randomized trial was performed to compare the effectiveness of intravenous vinorelbine tartrate with fluorouracil and leucovorin (5-FU/LV) on primary end points survival, quality life (QOL), relief cancer-related symptoms in patients advanced non-small-cell lung cancer (NSCLC). Secondary included tumor response rates time treatment failure. In addition, safety both regimens evaluated this multicenter study. PATIENTS AND METHODS Two hundred sixteen stage IV NSCLC were...
Reproduction by binary fission generates a clonal genetic structure in bacterial populations the absence of high rate recombination. The extent recombination natural ofNeisseria gonorrhoeae was determined from an analysis electrophoretically demonstrable allelic variation at structural genes encoding nine enzyme loci 227 worldwide isolates. No significant linkage disequilibrium evident population, indicating that must be frequent, relative to fission. N. compared with Bacillus subtilis...
We conducted a randomized trial comparing adjuvant treatment with edrecolomab versus observation in patients resected, low-risk, stage II colon cancer. This study also prospectively studied patient- and tumor-specific markers of outcome.After surgical resection, cancer were randomly assigned to either five infusions at 28-day intervals or without therapy.Final accrual included 1,738 patients; 865 received edrecolomab, 873 observed treatment. Median follow-up time was 7.9 years. There no...
Abstract Background Financial toxicity is a growing problem in oncology, but no prior studies have prospectively measured the financial impact of cancer treatment diverse national cohort newly diagnosed patients. S1417CD was first cooperative group-led multicenter prospective study to evaluate hardship metastatic colorectal (mCRC) Methods Patients aged 18 years or older within 120 days mCRC diagnosis completed quarterly questionnaires for 12 months. We estimated cumulative incidence major...
To our knowledge, NRG/RTOG 9804 is the only randomized trial to assess impact of whole breast irradiation (radiation therapy [RT]) versus observation (OBS) in women with good-risk ductal carcinoma situ (DCIS), following lumpectomy. Long-term results focusing on ipsilateral recurrence (IBR), primary outcome, are presented here.Eligible patients underwent lumpectomy for DCIS that was mammogram detected, size ≤ 2.5 cm, final margins ≥ 3 mm, and low or intermediate nuclear grade. Consented were...
<h3>Importance</h3> A poor prognostic understanding regarding curability is associated with lower odds of hospice use among patients cancer. However, the association between or discordance and health care older adults advanced incurable cancers not well characterized. <h3>Objective</h3> To evaluate patient-oncologist hospitalization cancers. <h3>Design, Setting, Participants</h3> This was a post hoc secondary analysis cluster randomized clinical trial that recruited from October 29, 2014, to...
4015 Background: The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism that exploited by tumors to prevent and evade anti-tumor immunity. Inhibitors of the IDO pathway, such as indoximod, are an increasingly validated class potential cancer therapeutics. combination gemcitabine (G) nab-paclitaxel (N) current SOC for metastatic pancreas (MPC). Pre-clinical models have demonstrated synergy between indoximod chemotherapy. Methods: Single arm study with (1200mg BID...
To determine in a prospective randomized trial whether high-dose orally administered medroxy-progesterone acetate (MPA) was superior to tamoxifen patients with recurrent or metastatic breast cancer who had received no prior endocrine therapy either the adjuvant advanced setting.Patients initially 20 mg/d MPA 1 g/d orally. At time of disease progression, were crossed over other regimen. Eligibility required be age > = 18 years, performance status 0 3, and estrogen receptor (ER)- progesterone...
3020 Background: Indoleamine 2,3 dioxygenase (IDO) is a tryptophan-catabolizing enzyme that plays key role in the normal regulation of peripheral immune tolerance. Tumors also employ this mechanism. In cancer, IDO can either be expressed by tumor cells themselves, or induced indirectly host antigen presenting cells. these settings, mediates an acquired tolerance, allowing evasion mediated destruction. Indoximod broad pathway inhibitor, shown to potentially interfere with multiple targets....