A5086110592- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Connective Tissue Growth Factor Research
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Artificial Intelligence in Healthcare and Education
- Pregnancy-related medical research
- FOXO transcription factor regulation
- Galectins and Cancer Biology
- AI in cancer detection
- Pregnancy and preeclampsia studies
- Microplastics and Plastic Pollution
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Cervical Cancer and HPV Research
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
Beijing Obstetrics and Gynecology Hospital
2020-2025
Capital Medical University
2020-2025
Hubei University
2024
Despite advances in various chemotherapy regimens, current therapeutic options are limited for ovarian cancer patients. Oxidative stress-induced growth inhibitor 1 (OSGIN1), which is a tumor suppressor gene known to regulate the cellular stress response and apoptosis, associated with development. However, underlying mechanisms involved ferroptosis regulation have not been elucidated. Thus, this study aimed investigate effect regulatory mechanism of OSGIN1 on cells. Our results demonstrated...
Ovarian cancer, one of the deadliest malignancies, lacks effective treatment, despite advancements in surgical techniques and chemotherapy. Thus, new therapeutic approaches are imperative to improving treatment outcomes. Immunotherapy, which has demonstrated considerable success managing various cancers, already found its place clinical practice. This review aims provide an overview ovarian tumor immunotherapy, including basics, key strategies, research data supporting potential. In...
Endometriosis (EMs) is defined as the presence of tissue somewhat resembling endometrial glands and stroma outside uterus; retrograded endometrium grows in peritoneal cavity elicits fibrosis. Ferroptosis a recently discovered form programmed cell death, which iron-dependent. The induction ferroptosis has been found to participate However, relationship between EMs fibrosis remains unknown. In this study, we confirmed that iron content ectopic stromal ovarian significantly increased. We...
Endometriosis (EMs) is a prevalent gynecological disorder characterized by the growth of uterine tissue outside cavity, causing debilitating symptoms and infertility. Despite its prevalence, exact mechanisms behind EMs development remain incompletely understood. This article presents comprehensive overview relationship between gut microbiota imbalance pathogenesis. Recent research indicates that plays pivotal role in various aspects EMs, including immune regulation, generation inflammatory...
Abstract Fibrosis constitutes the principal pathophysiological mediator of pain and infertility manifestations in endometriosis, inhibitory factor TGF-β pathway, MADH7, makes a vital impact on progression fibrosis. Ovarian tumour domain-containing protein 1 (OTUD1) deubiquitinase binds to MADH7 protein, although its specific role endometriosis needs be explored. This study is first explore OTUD1 investigate growth lesions vitro vivo, using C57BL/6N female mice primary human cells (HEMCs)....
The effectiveness of natural killer (NK) cells transferred adoptively in combating solid tumours is limited by challenges such as their difficulty penetrating from the bloodstream and maintaining viability without support interleukin-2 (IL-2). Genetically modified NK-92MI cells, which can release IL-2 to sustain viability, have been identified a promising alternative. This adaptation addresses negative consequences systemic administration. role PSD-95/discs large/ZO-1 (PDZ)-binding kinase...
To investigate the association of primary tumor site with prognosis in vulvar cancer, stratified by squamous cell carcinoma (SCC) and non-SCC histological types.
ABSTRACT Polystyrene micro‐ and nanoplastics (MNPs) are increasingly found in terrestrial environments, posing risks across the food web. However, potential impacts of MNPs transfer on plant‐insect interactions remains largely unknown. In this study, consumption willow plants ( Salix maizhokunggarensis ) exposed to 10.0 mg/L for 21 days inhibited survival reduced body weight Plagiodera versicolora larvae unlike those lower concentrations or shorter durations (0.1, 1.0 7 14 days). exposure...
Abstract The current treatments of ovarian cancer (OC) do not yield satisfactory outcomes. Hence, it is necessary to find new treatment targets for OC. In this study, a comprehensive bioinformatic analysis was conducted identify differentially expressed genes (DEGs) between OC and control tissues. Five datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially screened by comparing gene expression Module DEGs performed on STRING database GEPIA. Kaplan Meier...