A5065229492- Immune Cell Function and Interaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mast cells and histamine
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Circadian rhythm and melatonin
- Mosquito-borne diseases and control
- Neuroinflammation and Neurodegeneration Mechanisms
- Polyamine Metabolism and Applications
- Diverse Scientific Research Studies
- Respiratory viral infections research
- Inflammation biomarkers and pathways
- IL-33, ST2, and ILC Pathways
- Biochemical Analysis and Sensing Techniques
- Inflammasome and immune disorders
- Respiratory and Cough-Related Research
Fundação Oswaldo Cruz
2014-2022
Universidade Federal do Rio de Janeiro
2021
Influenza A virus (IAV) infection is a common cause of acute exacerbations chronic obstructive pulmonary disease (AECOPD). Since macrophage inflammatory protein 1 α, chemokine that acts through CC-chemokine receptor (CCR)-5, appears elevated in COPD patients’ airways, we evaluated whether CCR5 antagonist Maraviroc could inhibit the exacerbated lung response noted after IAV H1N1 mice exposed to cigarette smoke (Cs). C57BL/6 mice, subjected or not Cs inhalation for 11 days, were infected with...
Curine is a bisbenzylisoquinoline alkaloid and the major constituent isolated from Chondrodendron platyphyllum, plant that used to treat inflammatory diseases in Brazilian folk medicine. This study investigates effectiveness of curine on mast cell-dependent responses mice.To induce responses, Swiss mice were subcutaneously sensitized with ovalbumin (OVA-12 μg/mouse) Al(OH)3 0.9% NaCl solution. Fifteen days later, animals challenged OVA through different pathways. Alternatively, injected...
Abstract Glucagon has been shown to be beneficial as a treatment for bronchospasm in asthmatics. Here, we investigate if glucagon would prevent airway hyperreactivity (AHR), lung inflammation, and remodeling murine model of asthma. (10 100 µg/Kg, i.n.) significantly prevented AHR eosinophilia BAL peribronchiolar region induced by ovalbumin (OVA) challenge, while only the dose µg/Kg inhibited subepithelial fibrosis T lymphocytes accumulation lung. The inhibitory action occurred parallel with...
Glucocorticoids (GCs) are potent anti-allergic compounds that function, at least in part, by inhibiting signaling pathways mast cells. We hypothesized the GC-induced mastocytopenia and suppression of cell activation mediated advanced glycation end products (AGEs)/receptors AGEs (RAGEs) axis. evaluated role GC-mediated impaired degranulation male Wistar rats Swiss-Webster mice subcutaneously injected with dexamethasone or prednisolone (0.1 mg/kg) once a day for 21 consecutive days. The...
Regulatory T cells (Tregs) are important in regulating responses to innocuous antigens, such as allergens, by controlling the Th2 response, a mechanism that appears be compromised atopic asthmatic individuals. Different isogenic mouse strains also have distinct immunological and susceptibility experimental protocols used develop lung allergic inflammation. In this work, we investigated differences frequency of Treg cell subtypes among A/J, BALB/c, C57BL/6, under normal conditions following...
RATIONALE.Chronic obstructive pulmonary disease (COPD) is a major health problem associated with cigarette smoking.Influenza A virus (IAV) infections strongly exacerbate the symptoms and severity of COPD (AECOPD), increasing morbidity mortality, in mechanism related intensified leukocyte infiltration into lung tissue.Since smoke enhances CC-chemokine receptor (CCR) type 5 (CCR5) expression on both bronchial epithelium monocytes from patients, we evaluated here therapeutic potential CCR5...