A5072418754- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Nanomaterials for catalytic reactions
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Click Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Catalysis for Biomass Conversion
- Synthesis and Biological Evaluation
- Carbon dioxide utilization in catalysis
- Radical Photochemical Reactions
- Metal complexes synthesis and properties
- Vitamin D Research Studies
- Organoboron and organosilicon chemistry
- Synthesis and Catalytic Reactions
- Cholinesterase and Neurodegenerative Diseases
- CO2 Reduction Techniques and Catalysts
Ghent University
2019-2024
National and Kapodistrian University of Athens
2017-2024
Ruhr University Bochum
2024
Ghent University Hospital
2020-2023
N-Heterocyclic carbenes (NHCs) are nowadays ubiquitous in organometallic chemistry and catalysis. A simple synthetic route to these is presented.
Abstract The development of novel and operationally simple synthetic routes to carbene‐metal‐amido (CMA) complexes copper, silver gold relevant for photonic applications are reported. A mild base sustainable solvents allow all reactions be conducted in air at room temperature, leading high yields the targeted compounds even on multigram scales. effect various bases N−H metallation was studied silico experimentally, while a mechanochemical, solvent‐free approach also developed. Our...
Secondary ligand-metal interactions are decisive in many catalytic transformations. While arene-gold have repeatedly been reported as critical structural feature high-performance gold catalysts, we herein report that these can also be replaced by Au⋅⋅⋅H-C hydrogen bonds without suffering any reduction performance. Systematic experimental and computational studies on a series of ylide-substituted phosphines featuring either PPh3 (Ph YPhos) or PCy3 (Cy moiety showed the interaction...
Despite the unique position of gold catalysis in contemporary organic synthesis, this area research is notorious for requiring activators and/or additives that enable by generating cationic forms catalysts. Cycloisomerization reactions occupy a significant portion gold-catalyzed reaction space, while they represent diverse family are frequently utilized synthesis. Herein, hexafluoroisopropanol (HFIP) shown to be uniquely simple tool cycloisomerizations, rendering use external obsolete and...
N-heterocyclic carbene (NHC) ligands have evolved from being simple lab curiosities to tertiary phosphine mimics finally take center stage as unique supporting in organometallic chemistry, homogeneous catalysis, and more recently medicinal chemistry materials science applications. Some of these aspects are presented here a perspective researchers that been fascinated by the area for quite some time.
Two new Zn(II) complexes with tridentate hydrazone-based ligands (condensation products of 2-acetylthiazole) were synthesized and characterized by infrared (IR) nuclear magnetic resonance (NMR) spectroscopy single crystal X-ray diffraction methods. The 1, 2 recently [ZnL3(NCS)2] (L3 = (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium) complex 3 tested as potential catalysts for the ketone-amine-alkyne (KA2) coupling reaction. gas-phase geometry...
We have been puzzled by the involvement of weak organic and inorganic bases in synthesis metal-N-heterocyclic carbene (NHC) complexes. Such are insufficiently strong to permit presumed required deprotonation azolium salt (the precursor) prior metal binding. Experimental computational studies provide support for a base-assisted concerted process that does not require free NHC formation. The synthetic protocol was found applicable number transition-metal- main-group-centered compounds could...
Gold catalysis has witnessed immense evolution in recent years, yet it still requires the use of activators to render common [AuCl(L)] complexes catalytically active. Herein, H-bonding donor properties hexafluoroisopropanol (HFIP) are utilized for Au-Cl bond activation and ancillary ligand counteranion effects on cycloisomerization reactions showcased HFIP as solvent.
Tetrasubstituted propargylamines comprise a unique class of highly useful compounds, which can be accessed through the multicomponent coupling between ketones, amines, and alkynes (KA2 coupling), an underexplored transformation. Herein, development novel, efficient, user-friendly catalytic system for KA2 coupling, based on environmentally benign, inexpensive, readily available zinc acetate, is described. This employed in assembly unprecedented, tetrasubstituted derived from structurally...
The discovery of sustainable and scalable synthetic protocols leading to gold-aryl compounds bearing N-heterocyclic carbene (NHC) ligands sparked an investigation their reactivity potential utility as organometallic synthons. use a mild base green solvents provide access these compounds, starting from widely available boronic acids various [Au(NHC)Cl] complexes, with reactions taking place under air, at room temperature high yields unprecedented ease. One compound,...
Sodium acetate enables the synthesis of [Au(NHC)Cl] complexes, as well their Au-alkynyl and -thiolato derivatives in high yields, under air technical grade, green solvents. The mild synthetic methods are also investigated computationally.
Sustainable transformations towards the production of valuable chemicals constantly attract interest, both in terms academic and applied research. C–H activation has long been scrutinized this regard, given that it offers a straightforward pathway to prepare compounds great significance. In context, directing groups (DG) have paved way for chemical had not achievable using traditional reactions. Few steps, high yields, selectivity inert substrates are some invaluable assets directed...
Photocatalysis is a rapidly evolving area of research in modern organic synthesis. Among the traditional photocatalysts, metal-complexes based on ruthenium or iridium are most common. Herein, we present synthesis two photoactive, ruthenium-based complexes bearing pyridine-quinoline terpyridine ligands with extended aromatic conjugation. Our were utilized atom transfer radical addition (ATRA) haloalkanes to olefins, using bromoacetonitrile bromotrichloromethane as source alkyl group. The...
Herein, we describe a straightforward access to chalcogenoureas derived from N-heterocyclic carbenes, and investigate the coordination chemistry of selenoureas with coinage metals.
An efficient and chemoselective methodology deploying gold-N-heterocyclic carbene (NHC) complexes as catalysts in the hydrofluorination of terminal alkynes using aqueous HF has been developed. Mechanistic studies shed light on an situ generated catalyst, formed by reaction Brønsted basic gold pre-catalysts with water, which exhibits highest reactivity chemoselectivity. The catalytic system a wide alkyl substituted-substrate scope, stoichiometric well reactions tailor-designed enable...
A simple and eco-friendly route to gold<bold>–</bold>NHC complexes bearing different thiosugars is reported.
Abstract Herein, we report a catalytic system based on the earth‐abundant manganese for ketone, amine, alkyne (KA 2 ) reaction. The efficiency of manifests at relatively high temperatures, combined with sustainable reaction conditions, and provides tool accessing propargylamines from structurally diverse starting materials, including synthetically relevant bioactive molecules. Our efforts were also aimed shedding light mode action in this transformation, order to explain its...
A simple synthetic route, making use of inexpensive and environment-friendly solvent/reagents, is described leading to [Pt(NHC)(L)Cl<sub>2</sub>] [Pt(NHC)(dvtms)] (L = DMS, DMSO, Py; dvtms divynyltetramethylsiloxane) catalysts.
Abstract The modularity and ease of synthesis carbene‐metal‐amide (CMA) complexes based on the coinage metals (Au, Ag, Cu) N‐heterocyclic carbenes (NHCs) as ancillary ligands pave way for expansion their applications beyond photochemistry catalysis. Herein, we further improve such compounds by circumventing use toxic organic solvents which were previously required purification, expand scope to include incorporating carbolines amido fragments. novel are screened both in vitro ex vivo ,...