A5087301709- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Surface Chemistry and Catalysis
- Molecular Junctions and Nanostructures
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Porphyrin and Phthalocyanine Chemistry
- Crystallography and molecular interactions
- Surface and Thin Film Phenomena
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
- Graphene research and applications
- Fluorine in Organic Chemistry
- Topological Materials and Phenomena
- Machine Learning in Materials Science
- Advanced Chemical Physics Studies
- Covalent Organic Framework Applications
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Synthesis and pharmacology of benzodiazepine derivatives
- Circular RNAs in diseases
- Dendrimers and Hyperbranched Polymers
China Pharmaceutical University
2024-2025
East China University of Science and Technology
2015-2024
State Key Laboratory of Chemical Engineering
2018-2024
Soochow University
2024
Kunming University of Science and Technology
2020-2023
First People's Hospital of Yunnan Province
2020-2022
The emergence of spinon quasiparticles, which carry spin but lack charge, is a hallmark collective quantum phenomena in low-dimensional systems. While the existence spinons has been demonstrated through scattering spectroscopy ensemble samples, real-space imaging these quasiparticles within individual chains remained elusive. In this study, we construct Heisenberg antiferromagnetic spin-1/2 using open-shell [2]triangulene molecules as building blocks. Each unit, owing to its sublattice...
Lung cancer is the first leading cause of cancer-related deaths both worldwide and in China threatens human health quality life. New drugs therapeutic methods are urgently needed. Our study evaluated roles dihydroartemisinin (DHA) lung further explored its underlying mechanisms.CCK-8, colony formation trypan blue exclusion assays were used to detect cell viability, ability death. qRT-PCR Western blotting applied analyze expressions key molecules.DHA inhibited proliferation abilities enhanced...
Abstract On-surface synthesis provides tools to prepare low-dimensional supramolecular structures. Traditionally, reactive radicals are a class of single-electron species, serving as exceptional electron-withdrawing groups. On metal surfaces, however, such species affected by conduction band screening effects that may even quench their unpaired electron characteristics. As result, expected be less active, and reactions catalyzed surface-stabilized rarely reported. Herein, we describe...
Rhodium-catalyzed oxidative annulation of hydrazines with alkynes has been accomplished using 1,3-dinitrobenzene as an oxidant. A variety were converted to 1-aminoindole derivatives in good high yields. Mechanistic investigations support the idea that serves oxidant during C–H activation. This is, our knowledge, first report a nitrobenzene compound used transition-metal-catalyzed
On-surface Ullmann coupling reaction of aryl chlorides has been achieved on Cu(111), Ag(111), and Au(111), the mechanism investigated single molecule level using scanning tunneling microscopy density functional theory. The different reactivity halides was utilized to design a stepwise on-surface synthesis, which affords zigzag template then converts 2D porous networks.
Ladder phenylenes (LPs) composed of alternating fused benzene and cyclobutadiene rings have been synthesized in solution with a maximum length no longer than five units. Longer polymeric LPs not obtained so far because their poor stability insolubility. Here, we report the synthesis linear LP chains on Au(111) surface via dehalogenative [2+2] cycloaddition, which steric hindrance methyl groups 1,2,4,5-tetrabromo-3,6-dimethylbenzene precursor improves chemoselectivity as well orientation...
The combination of open-shell nanographenes (NGs) and magnetic transition metals holds great promise for generating various new quantum phases applicable in spintronics information technologies. However, a crucial aspect accomplishing this is to comprehend the exchange interactions between unpaired π- d-electrons, topic that has been seldom addressed. In study, we focus on π-d NGs coordination center Fe or Co by employing scanning tunneling microscopy spectroscopy. We synthesize two sets...
Rhodium-catalyzed addition–cyclization of hydrazines with alkynes has been achieved to afford highly substituted pyrazoles under mild conditions. The cascade reaction involves two transformations: addition the C–N bond via unexpected cleavage and intramolecular dehydration cyclization.
Abstract Two tunable cascade reactions of alkynols and alkynes have been developed by combining Sc(OTf) 3 rhodium catalysis. In the absence H 2 O, an endo ‐cycloisomerization/CH activation reaction provided 2,3‐dihydronaphtho[1,2‐ b ]furans in good to high yields. presence product alkynol hydration underwent addition/CH with alkyne, which led formation 4,5‐dihydro‐3 ‐spiro[furan‐2,1′‐isochromene] derivatives yields under mild conditions. Mechanistic studies indicated that rate‐determining...
As the first cascade C–H activation directed by a transient group, reaction of alkynols and 7-oxabenzonorbornadienes has been achieved via synergistic rhodium scandium catalysis to afford spirocyclic dihydrobenzo[a]fluorenefurans. This transformation proceeds hemiketal group activation, dehydrative naphthylation, intramolecular Prins-type cyclization. Mechanistic studies density functional theory calculations indicate that rate-determining step is bond cleavage both RhIII/ScIII play key roles.
The efficiency of Ullmann reaction aryl chlorides on an Au(111) surface has been substantially increased by using dosed Cu as a catalyst. different reactivity bromides and exploited to design programmed, on-surface synthesis form 2D covalent organic frameworks.
Open AccessCCS ChemistryRESEARCH ARTICLE10 May 2022Topological Defects Induced High-Spin Quartet State in Truxene-Based Molecular Graphenoids Can Li†, Yu Liu†, Yufeng Fu-Hua Xue, Dandan Guan, Yaoyi Li, Hao Zheng, Canhua Liu, Jinfeng Jia, Pei-Nian Deng-Yuan Li and Shiyong Wang Li† *Corresponding authors: E-mail Address: [email protected] Key Laboratory of Artificial Structures Quantum Control, Ministry Education, Shenyang National for Materials Science, School Physics Astronomy, Shanghai Jiao...
We employed three metal-coordination structures as templates to control the Sonogashira cross-coupling reactions on a Au(111) surface.
Intermolecular benzylic methylene functionalization of exo-cyclic enol ethers has been achieved using imines as reagents and potassium tert-butoxide the catalyst. Depending on solvent used, reaction proceeds by two pathways. In THF, an addition/elimination with provides dihydroisobenzofuran derivatives in good yield. DMSO, addition/ring-opening/cyclization cascade occurs unexpected cleavage C-O C-C bonds, affording isoquinolin-1(2H)-one products high yield under ambient conditions.
The emergence of quantum magnetism in nanographenes provides ample opportunities to fabricate purely organic devices for spintronics and information. Although heteroatom doping is a viable way engineer the electronic properties nanographenes, synthesis doped with collective remains elusive. Here, set nitrogen-doped (N-NGs) atomic precision are fabricated on Au(111) through combination imidazole [2+2+2]-cyclotrimerization cyclodehydrogenation reactions. High-resolution scanning probe...
Precisely introducing topological defects is an important strategy in nanographene crystal engineering because can tune π-electronic structures and control molecular assemblies. The synergistic of the synthesis assembly nanographenes by embedding to afford two-dimensional (2D) crystals on surfaces still a great challenge. By in-situ ladder bipyrazinylene (LBPy) into acene, narrowest with zigzag edges, we have achieved precise preparation 2D nonbenzenoid heteroacene Au(111). Through...
Transition metal-free cascade reactions of alkynols with imines have been achieved using potassium tert-butoxide as catalyst. Switching the reaction solvent gives two kinds products in good yield: isoquinolin-1(2H)-one derivatives and dihydroisobenzofuran derivatives. This approach was used to generate natural product 8-oxypseudopalmatine a two-step procedure from commercially available starting materials. Additionally, multicomponent alkynols, aldehydes, amines were also successfully afford
Radical cascade difluoroacetamidation of<italic>N</italic>-(arylsulfonyl)acrylamides with α,α-difluoro-α-(TMS)-acetamides has been achieved for the first time.
Abstract Dendrimers are homostructural and highly branched macromolecules with unique dendritic effects extensive use in multidisciplinary fields. Although thousands of dendrimers have been synthesized solution, the on-surface synthetic protocol for planar has never explored, limiting elucidation mechanism at single-molecule level. Herein, we describe an approach to dendrimers, which exogenous palladium is used as a catalyst address divergent cross-coupling aryl bromides isocyanides. This...
Dehalogenation plays a crucial role in on-surface synthesis, but the bond-forming sites dehalogenation occasionally differ from original halogen-substituted sites, leading to unexpected products. Revealing its mechanism is essential for atomically precise fabrication of low-dimensional nanomaterials, although it remains elusive. Herein, we report an isomerization organometallic polymers derived debromination on Ag(111) and elucidate involving intermolecular hydrogen transfer via combining...
Synthesizing radicals that have both long lifetimes and high chemical reactivity remains a long-term challenge. Here, persistent phenyl are successfully synthesized on Ag(111) by protecting the carbon radical site designing precursor molecule with suitable steric hindrance. As carbon-carbon coupling is prohibited, such remain intact for longer than 6 hours at room temperature Ag(111). Taking advantage of lifetimes, as-synthesized directly characterized in real space single-chemical-bond...