A5040124907- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular and exercise physiology
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Amyotrophic Lateral Sclerosis Research
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Esophageal and GI Pathology
- Non-Invasive Vital Sign Monitoring
- Muscle activation and electromyography studies
- Pulmonary Hypertension Research and Treatments
- Gastroesophageal reflux and treatments
- Hemodynamic Monitoring and Therapy
- Neurogenetic and Muscular Disorders Research
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Neuroscience of respiration and sleep
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014-2024
AC Camargo Hospital
2017-2024
Universidade de São Paulo
2012-2017
Impairment of (inspiratory and expiratory) respiratory muscles is a common clinical finding, not only in patients with neuromuscular disease but also primary the lung parenchyma or airways. Although such impairment common, its recognition usually delayed because signs symptoms are nonspecific late. This recognition, even lack thereof, occurs diagnostic tests used assessment muscle strength widely known available. There various methods assessing during inspiratory expiratory phases. These...
Objective: Evaluate the accuracy of criteria for diagnosing pressure overassistance during support ventilation. Design: Prospective clinical study. Setting: Medical-surgical ICU. Patients: Adults under mechanical ventilation 48 hours or more using and without any sedative 6 more. Overassistance was defined as occurrence work breathing less than 0.3 J/L 10% ineffective inspiratory effort. Two alternative definitions were based on esophageal pressure-time product 50 cm H 2 O s/min occlusion...
Abstract Background Fibrotic interstitial lung disease (FILD) patients are typically dyspneic and exercise-intolerant with consequent impairment of health-related quality life (HRQoL). Respiratory muscle dysfunction is among the underlying mechanisms dyspnea exercise intolerance in FILD but may be difficult to diagnose. Using ultrasound, we compared diaphragmatic mobility thickening cases healthy controls correlated these findings dyspnea, tolerance, HRQoL function. Methods We measured...
Most patients with unilateral diaphragm paralysis (UDP) have unexplained dyspnea, exercise limitations, and reduction in inspiratory muscle capacity. We aimed to evaluate the generation of pressure each hemidiaphragm separately its contribution overall strength.Twenty-seven patients, 9 right group (RP) 18 left (LP), forced vital capacity (FVC) < 80% pred, 20 healthy controls (CG), expiratory volume 1 s (FEV1) > pred FVC were evaluated for lung function, maximal (MIP) (MEP) measurements,...
Introduction COPD and interstitial lung disease (ILD) are significant chronic respiratory disorders, impacting quality of life. Respiratory muscle roles differences remain not entirely clear. The objective the present study was to evaluate degree recruitment muscles work breathing in ILD during exercise. Methods We compared sensory–mechanical relationships COPD, healthy controls (n=20 each). They performed pulmonary function, noninvasive invasive strength, surface electromyography...
Colorectal cancer is the third most diagnosed malignant neoplasm in world and fourth leading cause of mortality. The loss muscle mass oncological patients main aspect cancer-related malnutrition. Associations between sarcopenia poor outcomes, such as high postoperative mortality, chemotherapy toxicity, reduced survival, have been recently described. aim this study was to prospectively assess prevalence preoperative with colorectal using validated methods evaluate strength, mass, physical performance.
Thoracoabdominal asynchrony is the nonparallel motion of ribcage and abdomen. It estimated by using respiratory inductive plethysmography and, recently, optoelectronic plethysmography; however agreement measurements between these 2 techniques unknown. Therefore, present study compared with for measuring thoracoabdominal to see if were similar or different.27 individuals (9 healthy subjects, 9 patients interstitial lung disease, chronic obstructive pulmonary disease performed cycle ergometer...
Small airway and interstitial pulmonary involvements are prominent in chronic hypersensitivity pneumonitis (cHP). However, their roles on exercise limitation the relationship with functional lung tests have not been studied detail. Our aim was to evaluate performance its determinants cHP. We evaluated maximal cardiopulmonary testing 28 cHP patients (forced vital capacity 57±17% pred) 18 healthy controls during cycling. Patients had reduced lower peak oxygen production (16.6 (12.3-19.98)...
Patients with unilateral diaphragmatic paralysis (UDP) may present dyspnoea without specific cause and limited ability to exercise. We aimed investigate the diaphragm contraction mechanisms nondiaphragmatic inspiratory muscle activation during exercise in patients UDP, compared healthy individuals.Pulmonary function, as well volitional nonvolitional strength were evaluated 35 20 subjects. Respiratory pressures electromyography of scalene sternocleidomastoid muscles continuously recorded...
Abstract Background and objective The precise coordination of respiratory muscles during exercise minimizes work breathing avoids intolerance. Fibrotic interstitial lung disease (f‐ILD) patients are exercise‐intolerant. We assessed whether muscle incoordination thoracoabdominal asynchrony (TAA) occur in f‐ILD exercise, their relationship with pulmonary function performance. Methods compared pattern, mechanics, TAA recruitment 31 healthy subjects at rest incremental cycle exercise. was...
<b>Introduction:</b> To understand the respiratory work and its components during exercise has important role in limitation diseases. <b>Objective:</b> evaluate maximal interstitial lung disease (ILD) COPD, compared to controls, using Campbell Diagram. <b>Methods:</b> 7 ILD patients (47.7±15.4y, FVC 66.1±16.6%pred), 9 COPDs (60.1±8.6y, FEV1 44.2±19.7%pred) 8 healthy subjects (HS) (53.0±11.2y, 87.8±13.9%pred) underwent cardiopulmonary cycle ttest were monitored with esophageal balloon (Pes)....
<b>Rationale:</b> Dyspnea and augmented ventilatory muscle constrain are important determinants for exercise cessation in mainly severe COPD. However, these mechanisms were not fully evaluated mild patients (FEV<sub>1</sub>> 50% pred). <b>Objectives:</b> To evaluate the work, recruitment of inspiratory expiratory muscles dyspnea, at rest during maximum test, COPD compared to healthy controls. <b>Methods:</b> Cross-sectional study involving 12 50%pred) (FEV<sub>1</sub>< pred) COPDs, We...
Thoracoabdominal asynchrony (TAA) is defined as the no coincident motion of ribcage (RC) and abdomen (AB). It estimated by respiratory inductive plethysmography (RIP), recently with optoelectronic (OEP). The agreement TAA measurements both remains unknown. <b>OBJECTIVE:</b> to compare RIP OEP. <b>METHODS:</b> 9 healthy subjects; interstitial lung disease (ILD) (FVC<sub>1</sub> 57.2±10.8%pred) COPD patients (FEV<sub>1</sub>38±12.6%pred) performed 2 cycle ergometer tests 30 minutes between...
<b>Background:</b> Ultrasound (US) is a simple and reproducible method of assessing diaphragmatic mobility thickness. However, the correlation between US measurements, muscle strength, FVC FEV1 are not fully established even in healthies. <b>Aims:</b> To describe right mobility, thickness fraction evaluated by US; investigate these parameters with ventilatory strength spirometry. <b>Methods:</b> In cross-sectional study, 28 healthy volunteers performed spirometry hemidiaphragmatic...
<b>Background:</b> respiratory muscle dysfunction may contribute to exercise limitation in interstitial lung disease (ILD). Diaphragmatic was demonstrated by ultrasound (US) ILD patients. However, diaphragmatic described on US not correlated with functional parameters. <b>Aims:</b> correlate patients, mobility and thickness rest dyspnea, performance 6-minute-walk test (6MWT) quality of life (QOL). <b>Methods:</b> 28 controls 24 patients performed spirometry diaphragm evaluate deep breathing...
<b>Background:</b> Respiratory muscle weakness can contribute to limit exercise. However, respiratory recruitment and exercise-induced is not fully described even in healthies. <b>Objectives:</b> To describe the of muscles thoraco-abdominal synchrony at rest during exercise healthy subjects; measure non-volitive strenght after <b>Methods:</b> 42 healthies separated two groups: 20-39 (A) 40-59 y (B) underwent maximal cycle test. Esophageal (Pes), gastric (Pgas) transdiaphragmatic pressures...
<b>Introduction:</b> Total diaphragmatic strength is the result of contribution each hemidiaphragm. However, it unclear if this similar for both diaphragms or there a disparity. Moreover, compartmental behavior has not been investigated in patients with hemidiaphragm paralysis (HDP). <b>Objectives:</b> Evaluate total and its hemi compartments (right left) during phrenic twitch stimulation (Tw) controls HDP patients. <b>Methods:</b> 9 left diaphragm paralyis (LDP) (7male, 55.7±11.6 y) 16...