Pablo Bolaños‐Villegas

ORCID: 0000-0003-1729-0561
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About
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Research Areas
  • Plant Reproductive Biology
  • Chromosomal and Genetic Variations
  • Plant tissue culture and regeneration
  • Plant Molecular Biology Research
  • Microtubule and mitosis dynamics
  • Photosynthetic Processes and Mechanisms
  • Plant and animal studies
  • Plant Genetic and Mutation Studies
  • Lymphoma Diagnosis and Treatment
  • CRISPR and Genetic Engineering
  • Plant Virus Research Studies
  • DNA Repair Mechanisms
  • Cocoa and Sweet Potato Agronomy
  • Plant nutrient uptake and metabolism
  • Chronic Lymphocytic Leukemia Research
  • Genomics and Chromatin Dynamics
  • Science, Technology, and Education in Latin America
  • Plant Taxonomy and Phylogenetics
  • Banana Cultivation and Research
  • Flowering Plant Growth and Cultivation
  • Cutaneous lymphoproliferative disorders research
  • Oil Palm Production and Sustainability
  • Eosinophilic Disorders and Syndromes
  • Eosinophilic Esophagitis
  • CNS Lymphoma Diagnosis and Treatment

Universidad de Costa Rica
2015-2025

Hospital del Salvador
2010-2024

Mexican Social Security Institute
2021

National Chung Hsing University
2013-2016

Institute of Plant and Microbial Biology, Academia Sinica
2013-2016

Experimental Station
2015

Academia Sinica
2013-2014

National Taipei University
2013

Hospital Sant Joan de Déu Barcelona
2004

The proper transmission of DNA in dividing cells is crucial for the survival eukaryotic organisms. During cell division, faithful segregation replicated chromosomes requires their tight attachment, known as sister chromatid cohesion, until anaphase. Sister cohesion established during S-phase a process requiring an acetyltransferase that yeast Establishment 1 (Eco1). Inactivation Eco1 typically disrupts chromosome and homologous recombination-dependent repair cells, ultimately resulting...

10.1111/tpj.12261 article EN cc-by-nc The Plant Journal 2013-06-10

Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only effective treatment, and five-year survival rate advanced-stage patients less than 10%. Hence, exploring immunotherapy relevant, GBC immunogenicity poorly understood. This study examined relationship between host immune response patient based on presence tumor-infiltrating lymphocytes at...

10.1186/s12885-018-4147-6 article EN cc-by BMC Cancer 2018-03-02

Abstract Meiotic recombination increases genetic diversity and manipulation of its frequency distribution holds great promise in crop breeding. In Arabidopsis thaliana, FANCM (a homolog mammalian Fanconi anemia complementation group M) suppresses function seems conserved other species including the rosids Brassica spp. pea (Pisum sativum), monocot rice (Oryza sativa). To examine role during meiotic lettuce (Lactuca sativa, an asterid), we characterized LsFANCM found that it can functionally...

10.1093/plphys/kiab061 article EN PLANT PHYSIOLOGY 2021-02-10

The development of new cultivars in Doritaenopsis Guillaum. & Lami orchids is often hindered by factors such as low seed count hybrids. Cytological study may offer the ability to develop hybrids revealing with good chromosome pairing and high pollen viability, which are somewhat difficult obtain under current breeding programs. Cross pollination, chromosomal behavior during meiosis were analyzed reveal relation between fertility capsule set number mature capsules harvested their relative...

10.21273/jashs.133.1.107 article EN Journal of the American Society for Horticultural Science 2008-01-01

Ubiquitination is a post-translational modification process that plays central role in protein degradation eukaryotic cell division, including meiosis. This affects different cellular processes on global scale by its pleiotropic ability to modify numerous proteins. Meiosis essential for sexual reproduction and involves two rounds of nuclear division following single round DNA replication produce haploid gametes. Unlike mitosis, meiosis has unique prophase I, which homologous chromosome...

10.1199/tab.0187 article EN The Arabidopsis Book 2018-01-01

Double or triple-expressor lymphomas: prognostic impact of immunohistochemistry in patients with diffuse large B-cell lymphoma

10.1016/j.htct.2019.04.002 article EN cc-by-nc-nd Hematology Transfusion and Cell Therapy 2019-06-29

BET11 and 12 are required for pollen tube elongation. Pollen tubes rapidly growing specialized structures that elongate in a polar manner. They play crucial role the delivery of sperm cells through stylar tissues flower into embryo sac, where released to fuse with egg cell central give rise endosperm. Polar growth at tip is believed result from secretion materials by membrane trafficking mechanisms. In this study, we report functional characterization Arabidopsis BET12, two genes may code...

10.1186/s40529-015-0102-x article EN cc-by Botanical studies 2015-09-01

Sister chromatid cohesion, which is mediated by the cohesin complex, essential for proper segregation of chromosomes during mitosis and meiosis. Stable binding with regulated in part opposing actions CTF7 (CHROMOSOME TRANSMISSION FIDELITY7) WAPL (WINGS APART-LIKE). In this study, we characterized interaction between Arabidopsis thaliana conducting a detailed analysis wapl1-1 wapl2 ctf7 plants. plants exhibit major defects vegetative growth development are completely sterile. Inactivation...

10.1105/tpc.15.00781 article EN The Plant Cell 2016-01-26

articulo -- Universidad de Costa Rica. Escuela Agronomia, 2010. Este documento es privado debido a limitaciones derechos autor.

10.17660/actahortic.2010.878.15 article EN Acta Horticulturae 2010-10-01

Tropical and subtropical crops such as coffee, cacao, papaya are valuable commodities, their consumption is a seemingly indispensable part of the daily lives billions people worldwide. Conventional breeding these long, yields threatened by global warming. Traditional chromosome engineering new synthetic biology methods could be used to engineer chromosomes, facilitate transmission wild traits improve resistance stress disease in crops, hopefully boost yields. This review gives an overview...

10.3390/agronomy10010122 article EN cc-by Agronomy 2020-01-15

Multicellular organisms such as higher plants require timely regulation of DNA replication and cell division to grow develop. Recent work in Arabidopsis has shown that chromosome segregation during meiosis mitosis depends on the activity several genes yeast are involved establishment chromosomal cohesion. In this process, proteins STRUCTURAL MAINTENANCE OF CHROMOSOMES (SMC) family tether chromosomes establish inter- intrachromosomal connections. Arabidopsis, recruitment SMC cohesion key...

10.1080/15592324.2015.1013794 article EN Plant Signaling & Behavior 2015-05-04

This protocol is a more detailed version of previous protocols (Yang et al., 2011; Bolaños-Villegas 2013) developed for the examination meiotic chromosome spreads. Meiotic spreads are useful to determine presence defects in pairing and segregation. The also describes how perform fluorescent situ hybridization experiments with centromere probe used label chromosomes., 该方案是为研究减数分裂染色体扩散而开发的以前方案的更详细的版本(Yang等人,2011;Bolaños-Villegas等人,2013)。 减数分裂染色体扩散可用于确定染色体配对和分离中缺陷的存在。...

10.21769/bioprotoc.1102 article EN BIO-PROTOCOL 2014-01-01

Wildfires are a global and catastrophic phenomenon, generating major impacts on soil characteristics, erosion, water flow quality at the watershed scale, among others. Such effects depend severity of fire, metric that depends intensity fire nature vegetation is burning. During last 60 years average annual area burned in Chile due to wildfires has been approximately 65,000 hectares per year. This figure greatly surpassed 5 years, averaging 155,000 Although worldwide, especially United States...

10.5194/egusphere-egu24-8559 preprint EN 2024-03-08
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