A5030957254- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
University of Augsburg
2022-2023
Heidelberg University
2022-2023
Abstract Background Recently, we presented Stroma AReactive Invasion Front Areas (SARIFA) as a new histomorphologic negative prognostic biomarker in gastric cancer. It is defined direct contact between tumor cells and fat cells. The aim of this study was to further elucidate the underlying genomic, transcriptional, immunological mechanisms SARIFA phenomenon. Methods To address these questions, classified on H&E-stained tissue sections three cohorts: an external cohort ( n = 489,...
Primary tumors and distant site metastases form a bidirectionally communicating system. Yet, the molecular mechanisms of this crosstalk are poorly understood. Here, we identified proteolytically cleaved fragments angiopoietin-like 4 (ANGPTL4) as contextually active protumorigenic antitumorigenic contributors in communication ecosystem. Preclinical studies multiple tumor models revealed that C-terminal fragment (cANGPTL4) promoted growth metastasis. In contrast, N-terminal ANGPTL4 (nANGPTL4)...