A5021642381- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Reproductive Biology and Fertility
- Mycorrhizal Fungi and Plant Interactions
- Forest Ecology and Biodiversity Studies
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Lichen and fungal ecology
Tallinn University of Technology
2023-2025
University of Tartu
2019-2020
Soil microbiome has a pivotal role in ecosystem functioning, yet little is known about its build-up from local to regional scales. In multi-year regional-scale survey involving 1251 plots and long-read third-generation sequencing, we found that soil pH the strongest effect on diversity of fungi multiple taxonomic functional groups. The effects were typically unimodal, usually both direct indirect through tree species, nutrients or mold abundance. Individual particularly Pinus sylvestris,...
The plasticizer di(2-ethylhexyl) phthalate (DEHP) is known to have endocrine-disrupting properties mediated by its many metabolites that form upon exposure in biological systems. In a previous study, we reported an inverse association between DEHP the human ovarian follicular fluid (FF) and responsiveness of follicles controlled stimulation during vitro fertilization (IVF) treatments. Here, explored this further through molecular analysis FF samples. Ninety-six IVF patients from Swedish (N =...
Follicular fluid extracellular vesicles (FF EVs) facilitate communication between oocytes and somatic cells within the ovarian follicle, playing a pivotal role in follicular development. This study highlights molecular functional distinctions small (SEV) large (LEV) FF EV subpopulations, revealing their specialized regulatory roles granulosa cell (GC) biology consequential impact on function. Single-EV profiling uncovered distinct tetraspanin distributions, with LEVs containing lower...
The aryl hydrocarbon receptor (Ahr) is a ligand-activated transcription factor primarily known for its toxicological functions. Recent studies have established importance in many physiological processes including female reproduction, although there limited data about the precise mechanisms how Ahr itself regulated during ovarian follicle maturation. This study describes expression of granulosa cells (GCs) immature mice gonadotropin-dependent manner. We show that upregulation vivo requires...
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which mediates the effects of variety environmental stimuli in multiple tissues. Recent advances AHR biology have underlined its importance cells with high developmental potency, including pluripotent stem cells. Nonetheless, there little data on expression and role during initial stages cell differentiation. The purpose this study was to investigate temporal pattern directed differentiation human embryonic (hESC)...
Abstract Study question Can higher concentrations of di-2-ethylhexyl phthalate (DEHP) in follicular fluid (FF) lead to an altered microRNA expression profile? Summary answer The present study indicates the upregulation miR-203a-3p, miR-150-5p and miR-28-3p women with DEHP (FDR<0.05). What is known already Women are exposed daily endocrine-disrupting chemicals (EDCs) such as phthalates which can be found hundreds personal care products plastic items. In studies rodents certain...