A5009250178- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurogenesis and neuroplasticity mechanisms
- Sperm and Testicular Function
- Receptor Mechanisms and Signaling
- Selenium in Biological Systems
- Veterinary Orthopedics and Neurology
- Alzheimer's disease research and treatments
- Gastrointestinal disorders and treatments
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Health, Education, and Physical Culture
- Reproductive Biology and Fertility
- Cancer, Stress, Anesthesia, and Immune Response
- Plant Molecular Biology Research
- Advanced Radiotherapy Techniques
- Neurobiology and Insect Physiology Research
- Algal biology and biofuel production
- Gastrointestinal Bleeding Diagnosis and Treatment
Experimental Medicine and Biology Institute
2019-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2024
Stanford University
2022-2024
Palo Alto University
2024
Palo Alto Institute
2022
University of Antofagasta
2020
University of Buenos Aires
2015
Favaloro University
2013-2014
Universidad de Murcia
2010
Mammalian Cysteine-RIch Secretory Protein (CRISP) family includes four members present in sperm and reported to regulate Ca2+ channels fertilization. Based on our previous observations using single knockouts models suggesting the existence of functional compensation among CRISP proteins, we investigated their relevance for male fertility by generating multiple Crisp gene mutants CRISPR/Cas9 technology. Whereas targeting Crisp1 Crisp3 yielded subfertile males with early embryo developmental...
Regulation of food intake and energy balance depends on a group hypothalamic neurons that release anorexigenic melanocortins encoded by the Pomc gene. Although physiological importance central is well appreciated, genetic program defines functional identity melanocortin assures high levels expression only beginning to be understood. This study assessed whether transcriptional regulator PRDM12, identified as highly expressed gene in adult mouse POMC neurons, plays an important role function...
The melanocortin 4 receptor (MC4R) is a G protein-coupled that plays major roles in the central control of energy balance. Loss-of-function mutations MC4R constitute most common monogenic cause early-onset extreme obesity humans, whereas gain-of-function appear to be protective. In particular, two relatively frequent alleles carrying non-synonymous coding V103I or I251L are associated with lower risks and type-2 diabetes. Although MC4Rs showed more efficient signalling transfected cells,...
The molecular mechanisms that maintain circadian rhythms in mammalian as well non-mammalian systems are documented neuronal populations but comparatively understudied glia. Glia highly dynamic form and function, the clock provides broad ranges for maintenance of this homeostasis, thus glia key to understanding role biology brain function. Here, we highlight implications on homeodynamic nature glia, underscoring current gap system oligodendroglia lineage cells subsequent myelination. Through...
ABSTRACT Astrocytes are emerging as key regulators of neuronal synaptic network maturation and function, through control pruning. This is important, because individuals with ASD have excess glutamatergic synapses in the cortex, but biological mechanisms underlying this phenotype remain unclear. Here, we used human cortical organoids (hCO) derived from induced pluripotent stem cells (hiPSCs), to examine effect hypoxia on synapse engulfment astrocytes at postnatal-equivalent stages...
Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin ( POMC) gene. In mammals, arcuate-specific POMC expression is driven two cis -acting transcriptional enhancers known as nPE1 nPE2. Because mutant mice lacking these still showed Pomc mRNA, we searched for additional elements contributing to expression. By combining molecular evolution with reporter gene in transgenic zebrafish mice, here, identified mammalian...
The aim of the present study was to evaluate ability mice Mus musculus C57BL/6J strain form and evoke a visual recognition memory objects that differ only by their color. In order do this, we use paradigm novel objet (NOR), which takes advantage innate tendency explore object longer than familiar one. is first show preliminary results on long-term memories color in this mouse strain. addition, work suggests as model be used further research formation based
Abstract Objective The melanocortin 4 receptor (MC4R) is a G protein-coupled that plays major roles in the central control of energy balance. Loss-of-function mutations MC4R constitute most common monogenic cause early-onset extreme obesity humans, whereas gain-of-function appear to be protective. In particular, two relatively frequent alleles carrying non-synonymous coding V103I or I251L have been associated with lower risks and type-2 diabetes. Although MC4Rs showed more efficient...
Abstract Myelination depends on maintenance of oligodendrocytes that arise from oligodendrocyte precursor cells (OPCs). We show the dynamic nature oligodendroglia and myelination are regulated by circadian transcription factor BMAL1. Bmal1 knockdown in OPCs during development – but not adulthood decreases OPC proliferation, whereas BMAL1 regulates morphology throughout life. OPC-specific deficiency impairs remyelination an age-dependent manner, suggesting age-associated decrements regulation...