A5046788774- Force Microscopy Techniques and Applications
- Cellular Mechanics and Interactions
- Material Dynamics and Properties
- Phase Equilibria and Thermodynamics
- thermodynamics and calorimetric analyses
- Microfluidic and Bio-sensing Technologies
- Chemical Thermodynamics and Molecular Structure
- 3D Printing in Biomedical Research
- Physics of Superconductivity and Magnetism
- Advanced MEMS and NEMS Technologies
- Cell Adhesion Molecules Research
- Magnetic Field Sensors Techniques
- Mechanical and Optical Resonators
- Advanced Thermodynamics and Statistical Mechanics
- Thermal properties of materials
- Magnetic properties of thin films
- Advanced Fluorescence Microscopy Techniques
- Nanofabrication and Lithography Techniques
- Near-Field Optical Microscopy
- Thermodynamic properties of mixtures
- Carbon Nanotubes in Composites
- Digital Holography and Microscopy
- Liquid Crystal Research Advancements
- Advanced Electron Microscopy Techniques and Applications
- Glass properties and applications
Université Grenoble Alpes
2015-2024
Centre National de la Recherche Scientifique
2002-2024
Institut Néel
2008-2024
Laboratoire de Tribologie et Dynamique des Systèmes
2020
The University of Tokyo
2012-2014
Tokyo University of Science
2011-2013
Laboratory for Integrated Micro-Mechatronic Systems
2011-2013
Université Joseph Fourier
2002-2012
New York University
1998
The organization of cells into epithelium depends on cell interaction with both the extracellular matrix (ECM) and adjacent cells. role cell–cell adhesion in regulation epithelial topology is well-described. ECM better known to promote migration provide a structural scaffold for anchoring, but its contribution multicellular morphogenesis less well-understood. We developed minimal model system investigate how affects spatial intercellular junctions. Fibronectin micropatterns were used...
When spreading onto a protein microlattice living cells spontaneously acquire simple shapes determined by the lattice geometry. This suggests that, on lattice, cells' are in thermodynamic metastable states. Using model at equilibrium we able to reproduce observed shapes. We build phase diagram based two adimensional parameters characterizing essential cellular properties involved spreading: cell's compressibility and fluctuations.
Two phenomenological approaches are currently used in the study of vitreous state. One is based on concept fictive temperature introduced by Tool [J. Res. Natl. Bur. Stand. 34, 199 (1945)] and recently revisited Nieuwenhuizen [Phys. Rev. Lett. 80, 5580 (1998)]. The other thermodynamics irreversible processes initiated De Donder at beginning last century [L’Affinité (Gauthier-Villars, Paris, 1927)] Möller et al. for a thorough glass transition Chem. Phys. 125, 094505 (2006)]. This latter...
The effect of probe geometry on the classical Hall response to a weak perpendicular inhomogeneous magnetic field is studied numerically. An electric potential equation based model two-dimensional solved numerically for generalized flux distribution find function. We that magnitude and shape this function strongly affected by geometry. Asymmetric cross-shaped probes, with one narrow voltage lead, have peaked more localized than in symmetric arrangements. This suggests novel lithographic...
The thermodynamic treatment of the glass transition remains an issue intense debate. When associated with formalism non-equilibrium thermodynamics, lattice-hole theory liquids can provide new insight in this direction, as has been shown by Schmelzer and Gutzow [J. Chem. Phys. 125, 184511 (2006)]10.1063/1.2374894, Möller et al. 094505 (2006)]10.1063/1.2346673, more recently Tropin Non-Cryst. Solids 357, 1291 (2011)10.1016/j.jnoncrysol.2010.11.111; al., J. 1303...
Scanning Thermal Microscopy (SThM) has become an important measurement technique for characterizing the thermal properties of materials at nanometer scale. This requires a SThM probe that combines Atomic Force (AFM) and very sensitive resistive thermometer; thermometer being located apex tip allows mapping temperature or nanostructured with high spatial resolution. The interest in field nanoscience currently suffers from low sensitivity despite its To address this challenge, we developed...
Classically, the Prigogine–Defay (PD) ratio involves differences in isobaric heat capacity, isothermal compressibility, and thermal expansion coefficient between a super-cooled liquid corresponding glass at transition. However, determining such by extrapolation of coefficients that have been measured for glassy state, respectively, poses problem it does not exactly take into account non-equilibrium character In this paper, we assess question taking time dependence configurational...
In this paper, we show that closed-loop control can be advantageously used for the characterization of mechanical properties biomolecules using silicon nanotweezers (SNT). SNT have already been in open-loop mode DNA molecules. Up to now, such an approach allows detection stiffness variations equivalent about 15 Here, it is shown resolution inversely proportional resonance frequency whole system and real-time feedback with state observer drastically improve performances tweezers as...
We report on the imaging of biological cells including living neurons by a dedicated fibered interferometric scanning optical microscope. The topography and surface roughness mouse fibroblasts hippocampal are clearly revealed. This straightforward far-field technique allows fast, high resolution observation samples in liquids without lengthy alignment procedures or costly components.
We report the biomechanical characterization of λ-DNA bundle exposed to a therapeutic radiation beam by silicon Nanotweezers. The micromechanical device endures harsh environment beams, and still retains molecular-level detection accuracy. real-time DNA degradation is observed in terms stiffness viscosity reduction, both air solution. These results pave way for fundamental clinical studies mechanisms under ionizing improved tumor treatment.
The Hall response function of symmetric and asymmetric planar effect devices is investigated by scanning a magnetized tip above sensor surface while simultaneously recording the topography voltage. geometries are tailored using focused ion beam, in standard geometries. With this technique we able to reduce single voltage probe narrow constriction 20 times smaller than other device dimensions. We show that peaked constriction, agreement with numerical simulations. results suggest way pattern...
La transformation numérique est en marche. L’évolution permanente des compétences collaborateurs se retrouve au cœur de toutes les attentions. formation doit être immédiate, pratique et pragmatique, courte personnalisée. L’entreprise ne peut plus décalage avec cette réalité. Chaque entreprise choisir comment investir dans ce changement. Naval Group a fait le choix doter d’une entité interne dédiée à l’apprentissage clients : University. Le digital diversement disponible suivant moyens mis...
Thermal conductivity of diamond-like-carbon nanowire is investigated by combining MEMS in TEM (transmission electron microscope) with a new cryogenic holder allowing in-situ electrical measurements from 90K to 380K. A suspended DLC 80nm diameter and 10mic length was locally grown FIB-CVD between an integrated micro-heater temperature sensor. Combined special Wheastone bridge configuration, we show drastic improvement detection on the sensor estimate thermal conductance at low TEM.
This paper describes an integrated biomechanical platform for real-time molecular or cellular assays. is composed of silicon nanotweezers to manipulate the biological samples and open microfluidic handle solution reactive agents. The tweezers are fabricated by standard Silicon-On-Insulator based micromachining processes (2 masks +1 additional mask special tips) integrate actuator, trapping tips sensor. device produced from common polydimethylsiloxane (PDMS) micromolding integrates active...
Les proprietes de transport electrique dans les solides decoulent en toute logique celles des electrons la matiere. Dans une approche essentiellement phenomenologique, il est fait appel au modele classique Drude Lorentz et a celui quantique Sommerfeld. Ce dernier reprend l’hypothese du premier y incluant quantiques electrons, introduisant concepts essentiels comme densite charge, le libre parcours moyen ou d'etat. Ces modeles permettent relier transports charges d'autres notamment chaleur....
We report on the 3-dimensional imaging of biological cells including living neurons by a recently developed fibered interferometric Scanning Optical Microscope. The topography and surface structure mouse fibroblasts hippocampal are clearly revealed. This straightforward technique allows fast, high resolution observation samples in liquids without lengthy alignment procedures or costly components.