A5060526782- Urological Disorders and Treatments
- Genital Health and Disease
- Urologic and reproductive health conditions
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Urinary and Genital Oncology Studies
- Hormonal and reproductive studies
- Tissue Engineering and Regenerative Medicine
- Cancer and Skin Lesions
- Electrospun Nanofibers in Biomedical Applications
- Reconstructive Surgery and Microvascular Techniques
- Urinary Bladder and Prostate Research
- Congenital Diaphragmatic Hernia Studies
- Hedgehog Signaling Pathway Studies
- Hernia repair and management
- Nonmelanoma Skin Cancer Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Sexuality, Behavior, and Technology
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ureteral procedures and complications
- Particle accelerators and beam dynamics
- Renal and related cancers
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Tsinghua University
2024
Tongji Hospital
2023
Huazhong University of Science and Technology
2023
Chengdu University of Traditional Chinese Medicine
2023
Indiana University School of Medicine
2019
Shanghai Sixth People's Hospital
2012-2018
Wuxi Ninth People's Hospital
2016
Soochow University
2016
Extramammary Paget disease (EMPD) is a rare malignant dermatosis with poorly defined outcomes. We investigated clinical characteristics of invasive EMPD at different anatomic sites and by subject demographics to determine prognostic factors for overall survival (OS). All patient data were collected from the Surveillance, Epidemiology, End Results (SEER) program, 1973–2013, U.S. National Cancer Institute. Patients skin, vulva/labia, vagina, scrotum/penis, or other included. After excluding...
Abstract Rationale Tissue engineering is a promising alternative for urethral reconstruction, and adipose-derived stem cells (ADSCs) are widely used as seeding cells. Hypoxia preconditioning can significantly enhance the therapeutic effects of ADSCs. The low oxygen tension postoperative wound healing inevitable may facilitate nutritional function This study aimed to investigate if hypoxia-preconditioned ADSCs, compared normoxia-preconditioned combined with scaffold could better promote...
Background It remains uncertain whether a bedtime dose of selective α1 adrenoceptor antagonist could result in nocturnal hypotension elderly patients with benign prostate hyperplasia (BPH). Methods A total 253 older men BPH who had taken antagonists before sleep were consecutively recruited from the Geriatric Department Shanghai Ninth People’s Hospital. 221 finally included analysis qualified data including office blood pressure examinations, biochemical tests blood, and 24-hour ambulatory...
It is still debatable whether single- or two-stage urethroplasty a more suitable technique for treating hypospadias with severe chordee after urethral plate transection. This retrospective study evaluated these two techniques. A total of 66 patients proximal were divided into groups according to the techniques they underwent: 32 and 34 underwent single-stage (Duckett) urethroplasty, respectively. Median ages at presentation 7.5 years 11.0 in repair groups, follow-ups 28.5 months (20−60...
Background/Aims: Aggregation of insoluble α-synuclein to form Lewy bodies (LBs) may contribute the selective loss midbrain dopaminergic neurons in Parkinson disease (PD). Lack robust animal models has impeded elucidation molecular mechanisms LB formation and other critical aspects PD pathogenesis. Methods: We established a mouse model with targeted deletion plasminogen-binding protein tetranectin (TN) gene (TN-/-) measured behavioral histopathological features PD. Results: Aged (15-to...
A glucose biosensor was constructed by using highly dispersed gold nanoparticles supported on palladium nanowire arrays(Au-PdNWs)as sensing interface. The property of the detected cyclic voltammetry and chronoamperometry use composite nanomaterial led to an efficient enzyme loading, showing a perfect catalytic activity towards oxidation glucose. exhibited excellent sensitivity (detection limit down 0.001mM), short response time (about 5 sec) wide linear range (from 0.05 mM). Furthermore,...
To report the surgical management, complications and prognosis of patients with penoscrotal extramammary Paget's disease (EMPD) at different clinical stages. Between 2003 2008, a total 30 male EMPD were enrolled evaluated. All subjects received frozen biopsy-guided local wide resection immediate reconstruction. Patients followed every 3 months postoperatively. Among who accepted underwent treatment reconstruction, two (6.7%) cases exhibited positive margins, verified by pathological...
The staged graft urethroplasty is a recommended technique for repairing complex hypospadias. This retrospective study aimed to investigate the outcomes of this in hypospadias patients undergoing reoperation and analyze underlying contributing factors including age, meatus location, suture type. We retrospectively analyzed 40 who received oral urethroplasty, 15 buccal mucosal grafts 25 lingual grafts. Median age at presentation was 18.5 years, median follow-up 17.5 months (range 8–30 months)....
In this study, we investigated the genetics, clinical features, and therapeutic approach of 14 patients with 5α-reductase deficiency in China. Genotyping analysis was performed by direct sequencing PCR products steroid type 2 gene (SRD5A2). The activities three novel mutations were mutagenesis an vitro transfection assay. Most presented a microphallus, variable degrees hypospadias, cryptorchidism. Eight (57.1%) initially reared as females changed their social gender from female to male after...
Steroid 5α-reductase type 2 deficiency (5α-RD2) and androgen insensitivity syndrome (AIS) are difficult to distinguish clinically biochemically, adrenal-derived androgens have not been investigated in these conditions using modern methods. The objective of the study was compare Chinese patients with 5α-RD2, AIS, healthy men. Sixteen 10 39 men were included. Serum profiles compared subjects liquid chromatography/tandem mass spectrometry (LC-MS/MS). Based on clinical features laboratory tests,...
Anterior urethral reconstruction is still a challenging clinical task, and tissue engineering technology offers new options for anterior urethroplasty. In this work, we evaluated an extracellular matrix (ECM) mimicking scaffold in New Zealand white rabbit model. After the creation of defect, ECM-mimicking was applied six rabbits, small intestinal submucosa (SIS) used three rabbits. The outcomes urethrography histological analysis were months postoperatively. A larger diameter observed...
This study describes and compares three surgical procedures for the construction of urethral stricture (US) models in rabbits.Forty adult male rabbits were allocated to four groups: 36 randomly assigned experimental groups, while remaining 4 a sham group. The penis was separated from rectum. Then along ventral midline, longitudinal penile skin incision made ensuring that mucosa intact muscular layer not completely incised. In group 1 (n=12), semi-circumferential electrocoagulation 1-cm...
To evaluate the therapeutic effect of surgery in patients with advanced penile cancer, who have a dismal prognosis. Between September 2007 and July 2015, we treated 12 surgical therapy. The median follow-up period for all was 16 months (range 4–60 months). outcome concomitant symptoms were analyzed, survival rates calculated. Three are currently alive. overall 9 4–13 present results suggest that is valuable treatment option cancer. prognosis cancer closely related to lymph node distant...