A5001129223- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Nutrition, Genetics, and Disease
- Prostate Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Adrenal and Paraganglionic Tumors
- Sexual function and dysfunction studies
- Geomagnetism and Paleomagnetism Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Kidney Stones and Urolithiasis Treatments
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Pediatric Urology and Nephrology Studies
Kunming Medical University
2015-2025
Innovation Team (China)
2022-2025
Bladder Cancer Advocacy Network
2024
Second Affiliated Hospital of Kunming Medical College
2024
Yunnan Provincial Infectious Disease Hospital
2024
First Affiliated Hospital Zhejiang University
2022-2023
Federal Reserve
2023
Creative Commons
2023
In-Q-Tel
2023
Hangzhou Medical College
2023
Abstract Background The prognostic management of bladder cancer (BLCA) remains a great challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as marker many cancers but do not accurately detect core cellular and molecular functions in tumor cells. In the current study, single-cell RNA (scRNA-seq) were combined to construct model BLCA. Methods BLCA scRNA-seq downloaded from Gene Expression Omnibus (GEO) database. Bulk obtained UCSC Xena. R package "Seurat" was...
Abstract Objectives Development and validation of a computed tomography urography (CTU)‐based machine learning (ML) model for prediction preoperative pathology grade upper urinary tract urothelial carcinoma (UTUC). Methods A total 140 patients with UTUC who underwent CTU examination from January 2017 to August 2023 were retrospectively enrolled. Tumor lesions on the unenhanced, medullary, excretory periods used extract Features, respectively. Feature selection was screened by Pearson...
Background: Robot-assisted laparoscopic cystectomy with intracorporeal urinary diversion (iRARC) is increasingly being used in recent years. Whether iRARC offers advantages over open radical (ORC) remains controversial. This study aimed to compare the difference of perioperative outcomes, oncological outcomes and complications between ORC. Methods: The PubMed, Embase, Cochrane Library, Web Science CNKI databases were searched July 2023 according PRISMA (Preferred Reporting Items for...
Endometriosis (EMs) is a common disease in women of childbearing age, categorized into ovarian, superficial, and deep infiltrating endometriosis (DIE). Bladder (BE) type DIE with an incidence approximately 1% among age. Its main symptoms include pelvic discomfort urinary dysfunction. Importantly, bladder ureteral are distinct entities different clinical manifestations management approaches. As the condition progresses, it can involve ureters, leading to hydronephrosis severe renal function...
// Huan Xu 1, * , Shi Fu Qi Chen 1 Meng Gu Juan Zhou Chong Liu Yanbo Zhong Wang Department of Urology, Shanghai 9th People’s Hospital, Jiaotong University School Medicine, 200011, China These authors contributed equally to this work Correspondence to: Wang, email: zhongwang2000@sina.com Chen, fantasy_cyb@163.com Keywords: prostate cancer, oxytocin, APPL1, metabolism, proliferation Received: November 07, 2016 Accepted: March 01,...
Purpose . We evaluated the effect of sulforaphane (SFN) treatment on function and changes expression Nrf2‐ARE pathway in bladder rats with outlet obstruction (BOO). Materials Methods A total 18 male Sprague‐Dawley at age 8 weeks were divided into 3 groups (6 each): sham operated group, BOO BOO+SFN group. examined histological alterations oxidative stress markers protein pathway. Results found that SFN could prolong micturition interval increase capacity compliance. However, peak voiding...
BackgroundThe metabolism of arginine, a conditionally essential amino acid, plays crucial role in cancer progression and prognosis. However, more detailed understanding the influence arginine biosynthesis genes is currently unavailable.MethodsWe performed an integrative multi-omics analysis using The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases to determine characteristics these across multiple types. To measure overall activity cancer, we calculated scores based on...
<title>Abstract</title> <bold>Background: </bold>Bladder cancer (BLCA) is a common malignancy with significant impact on patient health. The aim of this study was to explore the potential mechanisms BLCA through combination multi-omics and single-cell analyses. <bold>Methods: </bold>In study, samples from paracancerous tissues were collected for transcriptome, whole-exome sequencing, metabolome intratumoural microbiome sequencing. These data then co-analyzed publicly available datasets...
Background: Bladder cancer (BLCA) is a common malignant tumor whose pathogenesis has not yet been fully elucidated. This study analyzed prognostic genes in BLCA by integrating transcriptomics and proteomics data, established models, aiming to offer novel insights for therapy. Methods: Transcriptomic, proteomic, protein acetylation sequencing were conducted on six tissues paraneoplastic tissue samples. Furthermore, data from TCGA-BLCA, GSE13507, single-cell RNA (scRNA-seq) datasets...
Background Clear cell renal carcinoma (ccRCC) is the most prevalent subtype of carcinoma, and immune checkpoint regulator-based immunotherapy has emerged as an effective treatment for advanced stages disease. However, expression patterns, prognostic significance, diagnostic value checkpoint-related genes (ICRGs) in ccRCC remain underexplored. This study utilized large-scale datasets from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), International Consortium (ICGC) to analyze...
Tobacco is a significant risk factor for bladder cancer, with notable disparities in smoking rates and cancer prevalence between sex. Our objective to assess the sex- age-specific burden of attributable China from 1990 2021, predict its future trends over next 15 years using GBD study data. All data were extracted 2021 study, utilizing metrics such as mortality rates, disability-adjusted life (DALYs), age-standardized (ASMR), DALY (ASDR) describe smoking-attributable China. We employed...
This study explores the causal relationship between sedentary behavior and urological cancers, focusing on bladder cancer (BC), prostate cancer, kidney using Bayesian Mendelian randomization mediation analysis. A two-sample (MR) framework was employed, genetic variants as instrumental variables. multivariate MR assessed effects of behaviors (TV watching, computer use, driving) cancers. Sensitivity analyses (MR-Egger, MR-PRESSO, Cochran Q ) ensured robustness. Mediation analysis identified...
e16547 Background: Poliovirus receptor (PVR) is a ligand for TIGIT and plays crucial role in tumor immune evasion. We have identified that PVR highly expressed bladder cancer (BC), particularly cases are resistant to immunotherapy. This study aims investigate whether antibody-drug conjugate (ADC) targeting can provide both antitumor activity inhibition of escape BC. Methods: Forty-one BC patients who received anti-PD1 neoadjuvant therapy were analyzed identify proteins linked immunotherapy...
The aim of the present study was to evaluate oxytocin and benign prostatic hyperplasia (BPH), cell signalling mechanism. Investigation performed in patients about correlation between level BPH. Mice were injected with or antagonist for 2 weeks prostate morphology studied after their sacrifice. Furthermore, vitro experiments effect through MEK/ERK/RSK pathway. Oxytocin significantly elevated serum tissue BPH, a positive volume indicated. In animal experiments, enlargement observed...
Mitochondria coordinated a lot of vital cellular processes energy production and distribution. Change mitochondrial functions has been implicated in cancer progression. The present study aims to investigate the involvement mitochondria dynamics LASS2 induced invasion chemoresistance bladder cells. J82 BIU87 cell lines were used for plasmid transfection while siRNA knockdown was carried out 5637 line. Matrigel assay Annexin V/PI staining demonstrated that negatively regulated chemoresistance....