A5047778191- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Personality Disorders and Psychopathology
- Mental Health and Psychiatry
- Posttraumatic Stress Disorder Research
- Cognitive Abilities and Testing
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Resilience and Mental Health
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Genetic Associations and Epidemiology
- Traumatic Brain Injury Research
- Birth, Development, and Health
- Attention Deficit Hyperactivity Disorder
- Early Childhood Education and Development
- Psychotherapy Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- Occupational Health and Performance
- Tryptophan and brain disorders
- Neural and Behavioral Psychology Studies
- COVID-19 and Mental Health
- Health, Environment, Cognitive Aging
- Bipolar Disorder and Treatment
- Eating Disorders and Behaviors
- Long-Term Effects of COVID-19
Rosalind Franklin University of Medicine and Science
2012-2025
Franklin University
2012-2024
Rosalind Franklin Institute
2021-2023
Stony Brook University
2016-2022
Vanderbilt University
2021
Psychologische Hochschule Berlin
2021
State University of New York
2016-2019
Stony Brook School
2018
King's College London
2013-2016
Medical Research Council
2016
Shortcomings of approaches to classifying psychopathology based on expert consensus have given rise contemporary efforts classify quantitatively. In this paper, we review progress in achieving a quantitative and empirical classification psychopathology. A substantial literature indicates that is generally more dimensional than categorical. When the discreteness versus continuity treated as research question, opposed being decided matter tradition, evidence clearly supports hypothesis...
Objective: Diagnosis is a cornerstone of clinical practice for mental health care providers, yet traditional diagnostic systems have well-known shortcomings, including inadequate reliability, high comorbidity, and marked within-diagnosis heterogeneity. The Hierarchical Taxonomy Psychopathology (HiTOP) data-driven, hierarchically based alternative to classifications that conceptualizes psychopathology as set dimensions organized into increasingly broad, transdiagnostic spectra. Prior work has...
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address shortcomings traditional mental disorder diagnoses, which suffer from arbitrary boundaries between psychopathology and normality, frequent co-occurrence, heterogeneity within disorders, diagnostic instability. This paper synthesizes evidence on the validity utility thought detachment spectra HiTOP. These are composed symptoms maladaptive traits currently subsumed schizophrenia, other psychotic schizotypal,...
The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address limitations traditional mental disorder diagnoses. These include arbitrary boundaries between and normality, co‐occurrence in the modal case, heterogeneity presentation within disorders, instability diagnosis patients. This paper reviews evidence on validity utility disinhibited externalizing antagonistic spectra HiTOP, which together constitute a broad superspectrum. are composed elements subsumed...
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological system that addresses shortcomings traditional mental disorder diagnoses, including arbitrary boundaries between psychopathology and normality, frequent co‐occurrence, substantial heterogeneity within disorders, diagnostic unreliability over time across clinicians. This paper reviews evidence on the validity utility internalizing somatoform spectra HiTOP, which together provide support for an emotional...
The DSM-5 classifies mood and anxiety disorders as separate conditions. However, some studies in adults find a unidimensional internalizing factor that underpins depression, while others support bidimensional model where symptoms segregate into distress (depression generalized anxiety) fear factors (phobia subscales). little is known about the phenotypic genetic structure of psychopathology children adolescents.To investigate associations between depression disorder symptom subscales to test...
Abstract Posttraumatic stress disorder (PTSD), a chronic resulting from severe trauma, has been linked to immunologic dysregulation. Gene expression profiling emerged as promising tool for understanding the pathophysiology of PTSD. However, date, all but one gene study was based on whole blood or unsorted peripheral mononuclear cell (PBMC), complex tissue consisting several populations cells. The objective this utilize RNA sequencing simultaneously profile four immune subpopulations (CD4T,...
Visual cortical responses are usually attenuated by repetition, a phenomenon known as repetition suppression (RS). Here, we use multivoxel pattern analyses of functional magnetic resonance imaging (fMRI) data to show that RS co-occurs with the converse (repetition enhancement, RE) in single region. We presented human volunteers short sequences repeated faces and measured brain activity using fMRI. In an independently defined face-responsive extrastriate region, response each voxel (RS vs....
Abstract The gene expression approach has provided promising insights into the pathophysiology of posttraumatic stress disorder (PTSD). However, few studies used hypothesis-free transcriptome-wide to comprehensively understand underpinning PTSD. A study using RNA sequencing whole blood was conducted in 324 World Trade Center responders (201 with never, 81 current, 42 past PTSD). Samples from current and never PTSD reponders were randomly split form discovery ( N = 195) replication 87)...
Background. Depression and anxiety persist within across diagnostic boundaries. The manner in which common v. disorder-specific genetic environmental influences operate development to maintain internalizing disorders their co-morbidity is unclear. This paper investigates the stability change of etiological on depression, panic, generalized, separation social symptoms, co-occurrence, adolescence young adulthood. Method. A total 2619 twins/siblings prospectively reported symptoms depression at...
Background Mindfulness-based therapies have been shown to be effective in treating depression and reducing cognitive biases. Anxiety sensitivity is one bias that may play a role the association between mindfulness depressive symptoms. It refers an enhanced toward symptoms of anxiety, with belief these are harmful. Currently, little known about mechanisms underpinning mindfulness, depression, anxiety sensitivity. The aim this study was examine genetic environmental factors trait its overlap...
Assessment of posttraumatic stress disorder (PTSD) has relied almost exclusively on retrospective memory symptoms, sometimes over long intervals. This approach creates potential for recall bias and obscures the extent to which symptoms fluctuate. The aim present study was examine discrepancy between self-reporting PTSD ecological momentary assessment (EMA), captures closer when they occur. also sought estimate degree vary or are stable in short-term. World Trade Center responders ( N = 202)...